1 AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 20, 2001 REGISTRATION NO. 333-54326 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ------------------------ POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ------------------------ REGENERON PHARMACEUTICALS, INC. (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER) NEW YORK 13-3444607 (STATE OR OTHER JURISDICTION OF (I.R.S. EMPLOYER INCORPORATION OR ORGANIZATION) IDENTIFICATION NO.) 777 OLD SAW MILL RIVER ROAD TARRYTOWN, NEW YORK 10591-6707 (914) 347-7000 (ADDRESS, INCLUDING ZIP CODE AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES) ------------------------ STUART A. KOLINSKI, ESQ. GENERAL COUNSEL REGENERON PHARMACEUTICALS, INC. 777 OLD SAW MILL RIVER ROAD TARRYTOWN, NEW YORK 10591-6707 (914) 347-7000 (NAME, ADDRESS, INCLUDING ZIP CODE AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE) ------------------------ COPIES TO: DAVID J. GOLDSCHMIDT, ESQ. JI HOON HONG, ESQ. SKADDEN, ARPS, SLATE, MEAGHER & FLOM LLP SHEARMAN & STERLING FOUR TIMES SQUARE 599 LEXINGTON AVENUE NEW YORK, NEW YORK 10036-6522 NEW YORK, NEW YORK 10022-6069 (212) 735-3000 (212) 848-4000 ------------------------ APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as practicable after this Post-Effective Amendment Registration Statement becomes effective. -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 2 ITEM 16. EXHIBITS. EXHIBIT NUMBER DESCRIPTION ------- ----------- 1 -- Form of Underwriting Agreement. 4.1 -- Stock Purchase Agreement dated January 13, 1988, by and between the Company, Leonard S. Schleifer and ML Venture Partners II, L.P. (the "Stock Purchase Agreement"). Incorporated by reference to Exhibit 10.1 to Regeneron's Registration Statement on Form S-1 (File No. 33-39043) (the "Regeneron S-1"). 4.2 -- Amendment to the Stock Purchase Agreement dated March 3, 1989. Incorporated by reference to Exhibit 10.2 to the Regeneron S-1. 4.3 -- Letter Agreement dated November 27, 1989, amending the Stock Purchase Agreement. Incorporated by reference to Exhibit 10.13 to the Regeneron S-1. 4.4 -- Class B Convertible Preferred Stock Purchase Agreement dated November 22, 1988, by and between the Company and each purchaser set forth on Exhibit A thereto. Incorporated by reference to Exhibit 10.3 to the Regeneron S-1. 4.5 -- Class D Convertible Preferred Stock Purchase Agreement dated August 31, 1990, by and between the Company and Amgen Inc. Incorporated by reference to Exhibit 10.9 to the Regeneron S-1. 4.6 -- Registration Rights Agreement, dated as of July 22, 1993, by and between the Company and Glaxo Group Limited. Incorporated by reference to Exhibit 4.7 to Regeneron's Registration Statement on Form S-3 (File No. 33-66788). 4.7 -- Registration Rights Agreement, dated as of April 15, 1996, by and between the Company and Amgen Inc. Incorporated by reference to Exhibit 10.3 to Regeneron's Form 10-Q for the quarter ended June 30, 1996, filed August 14, 1996. 4.8 -- Registration Rights Agreement, dated as of June 27, 1996, by and between the Company and Medtronic, Inc. Incorporated by reference to Exhibit 10.6 to Regeneron's Form 10-Q for the quarter ended June 30, 1996, filed August 14, 1996. 4.9 -- Registration Rights Agreement, dated as of December 11, 1996, by and between the Company and Procter & Gamble Pharmaceuticals. Incorporated by reference to Exhibit 10.30 to Regeneron's Form 10-K for the fiscal year ended December 31, 1996, filed March 26, 1997. 4.10 -- Registration Rights Agreement, dated as of May 13, 1997, by and between the Company and Procter & Gamble Pharmaceuticals. Incorporated by reference to Exhibit 10.3 to Regeneron's Form 10-Q for the quarter ended June 30, 1997, filed August 12, 1997. 4.11 -- Form of Certificate of shares of common stock. Incorporated by reference to Exhibit (a) to the Company's Form 8-A, filed with the Commission on February 20, 1991. 5 -- Opinion of Skadden, Arps, Slate, Meagher & Flom LLP. 23.1* -- Consent of PricewaterhouseCoopers LLP, Independent Accountants. 23.2* -- Consent of Ernst & Young LLP, Independent Auditors. 23.3 -- Consent of Skadden, Arps, Slate, Meagher & Flom LLP. Included in Exhibit 5. 24* -- Powers of Attorney. --------------- * Previously filed. II-1 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Village of Tarrytown, State of New York on March 20, 2001. REGENERON PHARMACEUTICALS, INC. By: /s/ LEONARD S. SCHLEIFER, M.D., PH.D. ------------------------------------------------- Leonard S. Schleifer, M.D., Ph.D. President and Chief Executive Officer SIGNATURE TITLE DATE --------- ----- ---- * Chairman of the Board March 20, 2001 --------------------------------------------------- P. Roy Vagelos, M.D. /s/ LEONARD S. SCHLEIFER, M.D., PH.D President, Chief Executive March 20, 2001 --------------------------------------------------- Officer and Director (Principal Leonard S. Schleifer, M.D., Ph.D Executive Officer) * Senior Vice President, Finance & March 20, 2001 --------------------------------------------------- Administration, Chief Financial Murray A. Goldberg Officer, Treasurer, and Assistant Secretary (Principal Financial Officer) * Controller and Assistant March 20, 2001 --------------------------------------------------- Treasurer (Principal Accounting Douglas S. McCorkle Officer) /s/ * Director March 20, 2001 --------------------------------------------------- Charles A. Baker /s/ * Director March 20, 2001 --------------------------------------------------- Michael S. Brown, M.D. /s/ * Director March 20, 2001 --------------------------------------------------- Alfred G. Gilman, M.D., Ph.D. /s/ * Director March 20, 2001 --------------------------------------------------- Joseph L. Goldstein, M.D. II-2 4 SIGNATURE TITLE DATE --------- ----- ---- /s/ * Director March 20, 2001 --------------------------------------------------- Fred A. Middleton /s/ * Director March 20, 2001 --------------------------------------------------- Eric M. Shooter, Ph.D. /s/ * Director March 20, 2001 --------------------------------------------------- George L. Sing *By:/s/ LEONARD S. SCHLEIFER, M.D., PH.D. Attorney-In-Fact March 20, 2001 --------------------------------------------------- Leonard S. Schleifer, M.D., Ph.D. II-3 5 EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION ------- ----------- 1 -- Form of Underwriting Agreement. 4.1 -- Stock Purchase Agreement dated January 13, 1988, by and between the Company, Leonard S. Schleifer and ML Venture Partners II, L.P. (the "Stock Purchase Agreement"). Incorporated by reference to Exhibit 10.1 to Regeneron's Registration Statement on Form S-1 (File No. 33-39043) (the "Regeneron S-1"). 4.2 -- Amendment to the Stock Purchase Agreement dated March 3, 1989. Incorporated by reference to Exhibit 10.2 to the Regeneron S-1. 4.3 -- Letter Agreement dated November 27, 1989, amending the Stock Purchase Agreement. Incorporated by reference to Exhibit 10.13 to the Regeneron S-1. 4.4 -- Class B Convertible Preferred Stock Purchase Agreement dated November 22, 1988, by and between the Company and each purchaser set forth on Exhibit A thereto. Incorporated by reference to Exhibit 10.3 to the Regeneron S-1. 4.5 -- Class D Convertible Preferred Stock Purchase Agreement dated August 31, 1990, by and between the Company and Amgen Inc. Incorporated by reference to Exhibit 10.9 to the Regeneron S-1. 4.6 -- Registration Rights Agreement, dated as of July 22, 1993, by and between the Company and Glaxo Group Limited. Incorporated by reference to Exhibit 4.7 to Regeneron's Registration Statement on Form S-3 (File No. 33-66788). 4.7 -- Registration Rights Agreement, dated as of April 15, 1996, by and between the Company and Amgen Inc. Incorporated by reference to Exhibit 10.3 to Regeneron's Form 10-Q for the quarter ended June 30, 1996, filed August 14, 1996. 4.8 -- Registration Rights Agreement, dated as of June 27, 1996, by and between the Company and Medtronic, Inc. Incorporated by reference to Exhibit 10.6 to Regeneron's Form 10-Q for the quarter ended June 30, 1996, filed August 14, 1996. 4.9 -- Registration Rights Agreement, dated as of December 11, 1996, by and between the Company and Procter & Gamble Pharmaceuticals. Incorporated by reference to Exhibit 10.30 to Regeneron's Form 10-K for the fiscal year ended December 31, 1996, filed March 26, 1997. 4.10 -- Registration Rights Agreement, dated as of May 13, 1997, by and between the Company and Procter & Gamble Pharmaceuticals. Incorporated by reference to Exhibit 10.3 to Regeneron's Form 10-Q for the quarter ended June 30, 1997, filed August 12, 1997. 4.11 -- Form of Certificate of shares of common stock. Incorporated by reference to Exhibit (a) to the Company's Form 8-A, filed with the Commission on February 20, 1991. 5 -- Opinion of Skadden, Arps, Slate, Meagher & Flom LLP. 23.1* -- Consent of PricewaterhouseCoopers LLP, Independent Accountants. 23.2* -- Consent of Ernst & Young LLP, Independent Auditors. 23.3 -- Consent of Skadden, Arps, Slate, Meagher & Flom LLP. Included in Exhibit 5. 24* -- Powers of Attorney. --------------- * Previously filed.