UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549


 
                                 SCHEDULE 13G/A
                                 (Rule 13d-102)

              Information Statement Pursuant to Rules 13d-1 and 13d-2
                     Under the Securities Exchange Act of 1934

                               (Amendment No. 1)*



                       LIGAND PHARMACEUTICALS INCORPORATED
-------------------------------------------------------------------------------
                                (Name of Issuer)


                                 Common Stock
-------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   53220KAB4
                          ---------------------------
                                (CUSIP Number)
 

                               December 31, 2004
              -----------------------------------------------------
              Date of Event Which Requires Filing of this Statement
 


Check the appropriate box to designate the rule pursuant to which this 
Schedule is filed:

	[x]	Rule 13d-1 (b)

	[ ]	Rule 13d-1 (c)

	[ ]	Rule 13d-1 (d)


*The remainder of this cover page shall be filled out for a reporting 
person's initial filing on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which 
would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be 
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section 
of the Act but shall be subject to all other provisions of the Act (however, 
see the Notes). 



--------------------------------------------------------------------------
CUSIP NO.  53220KAB4

--------------------------------------------------------------------------
1.  NAME OF REPORTING PERSON
    S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

	Highbridge International LLC - not applicable

--------------------------------------------------------------------------
2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                        (a)  [ ]
                                                        (b)  [ ]

--------------------------------------------------------------------------
3.  SEC USE ONLY



--------------------------------------------------------------------------
4.  CITIZENSHIP OR PLACE OF ORGANIZATION

	Cayman Islands, British West Indies

--------------------------------------------------------------------------
                5.  SOLE VOTING POWER

                    0

NUMBER OF     -----------------------------------------------------------
                6.  SHARED VOTING POWER
SHARES
                    $155,250,000 aggregate principal amount of 6% Convertible 
BENEFICIALLY        Subordinated Notes (the "Notes") due November 16, 2007  
                    (convertible into 2,790,772 shares of the issuer's common 
OWNED BY            stock (conversion rate of 161.9905 shares per $1,000
                    principal amount of the Notes).  
EACH                See footnote 1 in Item 4.
 
REPORTING     -----------------------------------------------------------
                7.  SOLE DISPOSITIVE POWER
PERSON
                    0
WITH 
              -----------------------------------------------------------
                8.  SHARED DISPOSITIVE POWER

                    See Row 6 above.

--------------------------------------------------------------------------
9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	See Row 6 above.

--------------------------------------------------------------------------
10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
	[   ]


--------------------------------------------------------------------------
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        Approximately 3.64%.  (Based on 73,932,315 shares of Common Stock 
        outstanding as of October 29, 2004, plus the Reporting Person's 
        shares of Common Stock issuable upon the conversion of the 
        Convertible Notes.)

--------------------------------------------------------------------------
12. TYPE OF REPORTING PERSON

	OO - Limited Liability Company




--------------------------------------------------------------------------
CUSIP NO.  53220KAB4

--------------------------------------------------------------------------
1.  NAME OF REPORTING PERSON
    S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

	Highbridge Capital Corporation - not applicable


--------------------------------------------------------------------------
2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                        (a)  [ ]
                                                        (b)  [ ]

--------------------------------------------------------------------------
3.  SEC USE ONLY



--------------------------------------------------------------------------
4.  CITIZENSHIP OR PLACE OF ORGANIZATION

	Cayman Islands, British West Indies


--------------------------------------------------------------------------
                5.  SOLE VOTING POWER

                    0

NUMBER OF     -----------------------------------------------------------
                6.  SHARED VOTING POWER
SHARES
                    $155,250,000 aggregate principal amount of 6% Convertible 
BENEFICIALLY        Subordinated Notes (the "Notes") due November 16, 2007  
                    (convertible into 2,790,772 shares of the issuer's common 
OWNED BY            stock (conversion rate of 161.9905 shares per $1,000
                    principal amount of the Notes).  
EACH                See footnote 1 in Item 4.
 
REPORTING     -----------------------------------------------------------
                7.  SOLE DISPOSITIVE POWER
PERSON
                    0
WITH 
              -----------------------------------------------------------
                8.  SHARED DISPOSITIVE POWER

                    See Row 6 above.

--------------------------------------------------------------------------
9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	See Row 6 above.

--------------------------------------------------------------------------
10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
	[   ]


--------------------------------------------------------------------------
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        Approximately 3.64%.  (Based on 73,932,315 shares of Common Stock 
        outstanding as of October 29, 2004, plus the Reporting Person's 
        shares of Common Stock issuable upon the conversion of the 
        Convertible Notes.)

--------------------------------------------------------------------------
12. TYPE OF REPORTING PERSON

	BD - Broker Dealer




--------------------------------------------------------------------------
CUSIP NO.  53220KAB4

--------------------------------------------------------------------------
1.  NAME OF REPORTING PERSON
    S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

	Highbridge Capital Management, LLC - 20-1901985


--------------------------------------------------------------------------
2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                        (a)  [ ]
                                                        (b)  [ ]

--------------------------------------------------------------------------
3.  SEC USE ONLY



--------------------------------------------------------------------------
4.  CITIZENSHIP OR PLACE OF ORGANIZATION

	State of Delaware


--------------------------------------------------------------------------
                5.  SOLE VOTING POWER

                    0

NUMBER OF     -----------------------------------------------------------
                6.  SHARED VOTING POWER
SHARES
                    $155,250,000 aggregate principal amount of 6% Convertible 
BENEFICIALLY        Subordinated Notes (the "Notes") due November 16, 2007  
                    (convertible into 2,790,772 shares of the issuer's common 
OWNED BY            stock (conversion rate of 161.9905 shares per $1,000
                    principal amount of the Notes).  
EACH                See footnote 1 in Item 4.
 
REPORTING     -----------------------------------------------------------
                7.  SOLE DISPOSITIVE POWER
PERSON
                    0
WITH 
              -----------------------------------------------------------
                8.  SHARED DISPOSITIVE POWER

                    See Row 6 above.

--------------------------------------------------------------------------
9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	See Row 6 above.

--------------------------------------------------------------------------
10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
	[   ]


--------------------------------------------------------------------------
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        Approximately 3.64%.  (Based on 73,932,315 shares of Common Stock 
        outstanding as of October 29, 2004, plus the Reporting Person's 
        shares of Common Stock issuable upon the conversion of the 
        Convertible Notes.)

--------------------------------------------------------------------------
12. TYPE OF REPORTING PERSON

	OO - Limited Liability Company




--------------------------------------------------------------------------
CUSIP NO.  53220KAB4

--------------------------------------------------------------------------
1.  NAME OF REPORTING PERSON
    S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

	                    Glenn Dubin


--------------------------------------------------------------------------
2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                        (a)  [ ]
                                                        (b)  [ ]

--------------------------------------------------------------------------
3.  SEC USE ONLY



--------------------------------------------------------------------------
4.  CITIZENSHIP OR PLACE OF ORGANIZATION

	United States


--------------------------------------------------------------------------
                5.  SOLE VOTING POWER

                    0

NUMBER OF     -----------------------------------------------------------
                6.  SHARED VOTING POWER
SHARES
                    $155,250,000 aggregate principal amount of 6% Convertible 
BENEFICIALLY        Subordinated Notes (the "Notes") due November 16, 2007  
                    (convertible into 2,790,772 shares of the issuer's common 
OWNED BY            stock (conversion rate of 161.9905 shares per $1,000
                    principal amount of the Notes).  
EACH                See footnote 1 in Item 4.
 
REPORTING     -----------------------------------------------------------
                7.  SOLE DISPOSITIVE POWER
PERSON
                    0
WITH 
              -----------------------------------------------------------
                8.  SHARED DISPOSITIVE POWER

                    See Row 6 above.

--------------------------------------------------------------------------
9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	See Row 6 above.

--------------------------------------------------------------------------
10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
	[   ]


--------------------------------------------------------------------------
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        Approximately 3.64%.  (Based on 73,932,315 shares of Common Stock 
        outstanding as of October 29, 2004, plus the Reporting Person's 
        shares of Common Stock issuable upon the conversion of the 
        Convertible Notes.)

--------------------------------------------------------------------------
12. TYPE OF REPORTING PERSON

	IN




--------------------------------------------------------------------------
CUSIP NO.  53220KAB4

--------------------------------------------------------------------------
1.  NAME OF REPORTING PERSON
    S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

	                    Henry Swieca


--------------------------------------------------------------------------
2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                        (a)  [ ]
                                                        (b)  [ ]

--------------------------------------------------------------------------
3.  SEC USE ONLY



--------------------------------------------------------------------------
4.  CITIZENSHIP OR PLACE OF ORGANIZATION

	United States


--------------------------------------------------------------------------
                5.  SOLE VOTING POWER

                    0

NUMBER OF     -----------------------------------------------------------
                6.  SHARED VOTING POWER
SHARES
                    $155,250,000 aggregate principal amount of 6% Convertible 
BENEFICIALLY        Subordinated Notes (the "Notes") due November 16, 2007  
                    (convertible into 2,790,772 shares of the issuer's common 
OWNED BY            stock (conversion rate of 161.9905 shares per $1,000
                    principal amount of the Notes).  
EACH                See footnote 1 in Item 4.
 
REPORTING     -----------------------------------------------------------
                7.  SOLE DISPOSITIVE POWER
PERSON
                    0
WITH 
              -----------------------------------------------------------
                8.  SHARED DISPOSITIVE POWER

                    See Row 6 above.

--------------------------------------------------------------------------
9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	See Row 6 above.

--------------------------------------------------------------------------
10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
	[   ]


--------------------------------------------------------------------------
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        Approximately 3.64%.  (Based on 73,932,315 shares of Common Stock 
        outstanding as of October 29, 2004, plus the Reporting Person's 
        shares of Common Stock issuable upon the conversion of the 
        Convertible Notes.)

--------------------------------------------------------------------------
12. TYPE OF REPORTING PERSON

	IN




Item 1.

(a)  Name of Issuer

	Ligand Pharmaceuticals Incorporated


(b)  Address of Issuer's Principal Executive Offices: 

	10275 Science Center Drive
	San Diego, California 92121-1117


Item 2(a).  Name of Person Filing
Item 2(b).  Address of Principal Business Office
Item 2(c).  Citizenship

This Schedule 13G/A is being filed on behalf of each of the following 
persons (each, a "Reporting Person"):

	Highbridge International LLC
        The Cayman Corporate Centre, 4th Floor
        27 Hospital Road
	Grand Cayman, Cayman Islands, British West Indies
	Citizenship: Cayman Islands, British West Indies
	
	Highbridge Capital Corporation
        The Cayman Corporate Centre, 4th Floor
        27 Hospital Road
	Grand Cayman, Cayman Islands, British West Indies
	Citizenship: Cayman Islands, British West Indies

	Highbridge Capital Management, LLC
	9 West 57th Street, 27th Floor
	New York, New York  10019
	Citizenship: State of Delaware

        Glenn Dubin
        c/o Highbridge Capital Management, LLC
        9 West 57th Street, 27th Floor
        New York, New York 10019
        Citizenship:	United States

        Henry Swieca
        c/o Highbridge Capital Management, LLC
        9 West 57th Street, 27th Floor
        New York, New York 10019
        Citizenship:	United States


(d)  Title of Class of Securities

	Common Stock

(e)  CUSIP Number	

        53220KAB4


Item 3.	 If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b),
 check whether the person filing is a:


(a) [X] Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
	
(b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) [ ] Insurance company as defined in section 3(a)(19) of the Act 
        (15 U.S.C. 78c).

(d) [ ] Investment company registered under section 8 of the Investment
        Company Act of 1940 (15 U.S.C. 80a-8).

(e) [ ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

        
(f) [ ] An employee benefit plan or endowment fund in accordance with
        Rule 13d-1(b)(1)(ii)(F);

(g) [ ] A parent holding company or control person in accordance with 
        Rule 13d-1(b)(1)(ii)(G);

(h) [ ] A savings associations as defined in Section 3(b) of the Federal
        Deposit Insurance Act (12 U.S.C. 1813);

(i) [ ] A church plan that is excluded from the definition of an investment 
        company under section 3(c)(14) of the Investment Company Act of 1940 
        (15 U.S.C. 80a-3);

(j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box. [ ]



Item 4.	Ownership

(a)  Amount Beneficially Owned

        $155,250,000 aggregate principal amount of 6% Convertible Subordinated 
        Notes due November 16, 2007 (convertible into 2,790,772 shares of the 
        issuer's common stock (conversion rate of 161.9905 shares per $1,000
        principal amount of the Notes)).  /1/


(b)  Percent of Class

        Approximately 3.64%.  (Based on 73,932,315 shares of Common Stock 
        outstanding as of October 29, 2004, plus the Reporting Person's 
        shares of Common Stock issuable upon the conversion of the 
        Convertible Notes.)


(c)  Number of shares as to which such person has:
      (i) sole power to vote or to direct the vote
             0

     (ii) shared power to vote or to direct the vote
             See item (a) above.

    (iii) sole power to dispose or to direct the disposition of
             0

     (iv) shared power to dispose or to direct the disposition of
             See item (a) above.


/1/     Highbridge International LLC is a wholly owned subsidiary of Highbridge 
Capital Corporation.  Highbridge Capital Management, LLC is the trading manager 
of Highbridge Capital Corporation.  Highbridge Capital Management, LLC is 
exempt from registration as an investment adviser.  Glenn Dubin is a Managing 
Partner of Highbridge Capital Management, LLC.  Henry Swieca is a Managing 
Partner of Highbridge Capital Management, LLC.  The persons at Highbridge 
Capital Management, LLC who actually exercise the power to dispose of and the 
power to vote the investments of Highbridge Capital Corporation are registered 
as registered representatives of Highbridge Capital Corporation, a registered 
broker/dealer.  As of the date of this Schedule, the Notes reported herein by 
the Reporting Persons may acquire in the future through the conversion of the 
$155,250,000 aggregate principal amount of 6% Convertible Notes due November 
16, 2007 of the Issuer, which may be converted by the Reporting Persons at any 
time prior to and including November 16, 2007 (the "Maturity Date") into 
2,790,772 shares of the Issuer's common stock (the Notes are convertible into 
161.9905 shares of common stock, par value $0.001 per share, per $1,000 
principal amount of notes and subject to adjustment in certain circumstances). 
Based on the Issuer's latest Form 10Q filed on November 9, 2004, there were 
73,932,315 shares of Common Stock outstanding as of October 29, 2004.  
Therefore, with the issuer's outstanding shares of Common Stock plus the 
Reporting Person's shares of Common Stock issuable upon the conversion of the 
Notes, the Reporting Persons may be deemed to beneficially own 3.64% of the 
outstanding shares of common stock of the Issuer.  The foregoing should not be 
construed in and of itself as an admission by any Reporting Person as to 
beneficial ownership of shares of Common Stock owned by another Reporting 
Person.


Item 5.  Ownership of Five Percent or Less of a Class

         If this  statement  is being filed to report the fact that as of the
         date  hereof the  Reporting  Person has ceased to be the  beneficial
         owner of more than five  percent of the class of  securities,  check
         the following [X].


Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

		Inapplicable

Item 7.  Identification and Classification of the Subsidiary Which Acquired 
the Security Being Reported on By the Parent Holding Company

		See Item 2 above.

Item 8.  Identification and Classification of Members of the Group

		See Item 2 above.

Item 9.  Notice of Dissolution of Group

		Inapplicable

Item 10. Certification


By signing below I certify that, to the best of my knowledge and belief, 
the securities referred to above were acquired and are held in the ordinary
course of business and were not acquired and are not held for the purpose 
of or with the effect of changing or influencing the control of the issuer 
of the securities and were not acquired and are not held in connection with 
or as a participant in any transaction having that purpose or effect.


                              SIGNATURE

After reasonable inquiry and to the best of its knowledge and belief, each of 
the undersigned certifies that the information with respect to it set forth in 
this statement is true, complete, and correct.


Dated this 14th day of February, 2005



Highbridge International LLC

By:  /s/  Howard Feitelberg
    -------------------------------------
     Howard Feitelberg, Director

	

Highbridge Capital Corporation

By:  /s/  Howard Feitelberg
    -------------------------------------
     Howard Feitelberg, Controller



Highbridge Capital Management, LLC

By:  /s/  Ronald S. Resnick	
    -------------------------------------
     Ronald S. Resnick, Managing Partner



/s/  Glenn Dubin 
-------------------------------------
Glenn Dubin



/s/  Henry Swieca 
-------------------------------------
Henry Swieca





                        Exhibit Index
                        -------------

              Exhibit                  Description
              -------                  -----------

                 1               Joint Filing Agreement