UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

       Date of Report (Date of earliest event reported): October 29, 2007

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
             (Exact name of Registrant as specified in its charter)



           Delaware                     0-26224                  51-0317849
(State or other jurisdiction of  (Commission File Number)    (I.R.S. Employer
incorporation or organization)                               Identification No.)


                              311 Enterprise Drive
                              Plainsboro, NJ 08536
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (609) 275-0500

                                 Not Applicable
          (Former name or former address, if changed since last report)


Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]  Written communications pursuant to Rule 425 under the Securities Act
     (17 CFR 230.425)

[ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act
     (17 CFR 240.14a-12)

[ ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

[ ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))







ITEM 2.01.  COMPLETION OF ACQUISITION OR DISPOSITION OF ASSETS

ACQUISITION OF ISOTIS, INC.

As previously announced, on August 6, 2007, Integra LifeSciences Holdings
Corporation, a Delaware corporation (the "Company"), entered into an Agreement
and Plan of Merger (the "Merger Agreement") by and among the Company, Ice
MergerCorp, Inc., a Delaware corporation and wholly owned subsidiary of the
Company ("Merger Sub"), and IsoTis, Inc., a Delaware corporation ("IsoTis"), as
described in the Current Report on Form 8-K filed by the Company on August 7,
2007. Pursuant to the Merger Agreement, on October 29, 2007, Merger Sub was
merged with and into IsoTis (the "Merger"). In the Merger, the Company paid
consideration of $7.25 in cash per share of IsoTis common stock, representing
total consideration of approximately $51 million.

IsoTis, based in Irvine, California, is an orthobiologics company that develops,
manufactures and markets proprietary products for the treatment of
musculoskeletal diseases and disorders.  The description of the terms of the
Merger Agreement is qualified in its entirety by reference to the copy of the
Merger Agreement as attached as Exhibit 10.1 to the Current Report on Form 8-K
filed by the Company on August 7, 2007.

A copy of the press release issued by the Company announcing the closing of the
Merger is attached as Exhibit 99.1 to this Current Report on Form 8-K and is
incorporated by reference into this Item.


ITEM 9.01.  FINANCIAL STATEMENTS AND EXHIBITS.

(d) Exhibits.

Exhibit Number   Description of Exhibit
--------------   ---------------------------

99.1             Press release issued October 29, 2007







                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended,
the Registrant has duly caused this report to be signed on its behalf by the
undersigned, hereunto duly authorized.

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION

        Date: October 30, 2007         By: /s/ Stuart M. Essig
                                           -----------------------------
                                           Stuart M. Essig
                                           President and Chief Executive Officer












                                 Exhibit Index


Exhibit Number   Description of Exhibit
--------------   ---------------------------

99.1             Press release issued October 29, 2007