FORM 5 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Form 3 Holdings Reported Form 4 Transactions Reported

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * HOMCY CHARLES J 2. Issuer Name and Ticker or Trading Symbol Global Blood Therapeutics, Inc. [GBT] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O GLOBAL BLOOD THERAPEUTICS, INC., 171 OYSTER POINT BLVD, SUITE 300 3. Statement for Issuer's Fiscal Year Ended (Month/Day/Year) 12/31/2016 (Street) SOUTH SAN FRANCISCO, CA 94080 4. If Amendment, Date Original Filed(Month/Day/Year) 02/14/2018 6. Individual or Joint/Group Reporting (check applicable line) _X_ Form Filed by One Reporting Person ___ Form Filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned at end of Issuer's Fiscal Year (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Amount (A) or (D) Price COMMON STOCK 11/14/2016   J(1) 14,611 D $ 0 223,117 D   COMMON STOCK 11/14/2016   J(1) 14,611 D $ 0 14,611 I By Charles Homcy Revocable Trust COMMON STOCK 11/23/2016   G(1)(2) 10,000 D $ 0 4,611 I By Charles Homcy Revocable Trust COMMON STOCK 12/23/2016   J(1) 10,432 D $ 0 212,685 D   COMMON STOCK 12/23/2016   J(1) 10,432 A $ 0 15,043 I By Charles Homcy Revocable Trust COMMON STOCK             1,600 I By Charles Homcy Irrevocable Trust

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

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SEC 2270 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
HOMCY CHARLES J C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD, SUITE 300 SOUTH SAN FRANCISCO, CA 94080	  X	Â	Â	Â

Signatures

/s/ Lesley Calhoun as Attorney-in-Fact for the Reporting Person		02/14/2018
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	This transaction was omitted from the Reporting Person's original Form 5, and the shares were not deducted from the Reporting Person's holdings in all Forms 4 filed by the Reporting Person after his original Form 5 was filed.
(2)	The Reporting Person's revocable trust gifted 10,000 shares to a charitable foundation on November 23, 2016. The reporting person disclaims beneficial ownership of the shares held by the charitable trust, and this report should not be deemed an admission that the reporting person is the beneficial owner of the charitable trust's shares for purposes of Section 16 or for any other purpose. This report is being filed with respect to this transaction solely to correct the total number of shares held directly and indirectly by the Reporting Person and his trusts immediately following the transaction.

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