FORM 5 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Form 3 Holdings Reported Form 4 Transactions Reported

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * SHROTRIYA RAJESH C MD 2. Issuer Name and Ticker or Trading Symbol SPECTRUM PHARMACEUTICALS INC [SPPI] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Chairman & CEO (Last) (First) (Middle) 11500 S. EASTERN AVE., SUITE 240 3. Statement for Issuer's Fiscal Year Ended (Month/Day/Year) 12/31/2015 (Street) HENDERSON, NV 89052 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Reporting (check applicable line) _X_ Form Filed by One Reporting Person ___ Form Filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned at end of Issuer's Fiscal Year (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Amount (A) or (D) Price Common Stock, $.001 Par Value 01/07/2015   G(1) 5,943 D $ 0 1,708,249 D   Common Stock, $.001 Par Value 12/17/2015   G(1) 7,167 D $ 0 1,708,249 D   Common Stock, $.001 Par Value 12/18/2015   G(2) 52,901 D $ 0 1,708,249 D   Common Stock, $.001 Par Value 12/18/2015   G(2) 52,901 A $ 0 498,894 I By CS Family Trust (2) Common Stock, $.001 Par Value 12/24/2015   G(3) 51,324 D $ 0 1,708,249 D   Common Stock, $.001 Par Value 12/24/2015   G(3) 51,324 A $ 0 87,018 I By Shrotriya Gift Trust (3) Common Stock, $.001 Par Value 12/29/2015   G(4) 4,420 D $ 0 73,669 I By Shrotriya Family Foundation (4) Common Stock, $.001 Par Value             9,523 I By Spouse Common Stock, $.001 Par Value             10,613 I By Shrotriya Annuity Trust Common Stock, $.001 Par Value             26,128 I By 401(k) plan

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

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SEC 2270 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
SHROTRIYA RAJESH C MD 11500 S. EASTERN AVE. SUITE 240 HENDERSON, NV 89052	  X	  X	  Chairman & CEO	Â

Signatures

Kurt A. Gustafson, attorney-in-fact for Rajesh C. Shrotriya		01/29/2016
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	This transaction involved a gift of securities by the reporting person to his three grandchildren who do not share the reporting person's household. The reporting person disclaims beneficial ownership of the shares held by his three grandchildren, and this report should not be deemed an admission that the reporting person is the beneficial owner of his grandchildren's shares for purposes of Section 16 or any other purpose.
(2)	Transfer for estate planning purposes by reporting person to the CS Family Trust. The reporting person has an indirect beneficial ownership as trustee of the CS Family Trust.
(3)	Transfer for estate planning purposes by reporting person to the Shrotriya Gift Trust. The reporting person has an indirect beneficial ownership through spouse, as trustee of the Shrotriya Gift Trust.
(4)	This transaction involved a gift of securities by the Shrotriya Family Foundation, a Nevada nonprofit corporation, to two nonprofit charitable organizations. The reporting person has an indirect beneficial ownership, as a director and officer of the Shrotriya Family Foundation, a Nevada nonprofit corporation.

Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure.

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