1. Title of Derivative Security (Instr. 4) |
2. Date Exercisable and Expiration Date (Month/Day/Year) |
3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) |
4. Conversion or Exercise Price of Derivative Security |
5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5) |
6. Nature of Indirect Beneficial Ownership (Instr. 5) |
Date Exercisable |
Expiration Date |
Title |
Amount or Number of Shares |
Common Stock Warrant (right to buy)
|
06/26/2006 |
10/30/2010 |
Common Stock
|
196,852
(2)
|
$
13.6
|
I
|
See footnote
(3)
|
Stock Option
|
10/12/2006 |
08/08/2011 |
Common Stock
|
5,000
|
$
14.28
|
D
|
Â
|
Common Stock Warrant (right to buy)
|
11/01/2006 |
10/30/2010 |
Common Stock
|
210,937
(2)
|
$
13.6
|
I
|
See footnote
(4)
|
Stock Option
|
10/06/2008 |
10/05/2018 |
Common Stock
|
15,000
|
$
6.24
|
D
|
Â
|
Common Stock Warrant (right to buy)
|
10/23/2008 |
10/23/2013 |
Common Stock
|
385,885
|
$
7.86
|
I
|
See footnote
(5)
|
* |
If the form is filed by more than one reporting person, see Instruction 5(b)(v). |
** |
Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). |
(1) |
The shares are held as follows: 2,685,521 by MPM BioVentures IV-QP, L.P. ("BV IV"), 103,461 by MPM BioVentures IV GmbH & Co. Beteiligungs KG ("BV KG") and 76,364 by MPM Asset Management Investors BV4 LLC ("AM BV4"). MPM BioVentures IV GP LLC and MPM BioVentures IV LLC are the direct and indirect general partners of BV IV, BV KG and AM BV4. The reporting person is a member of the general partner of BV IV and a member of AM BV4. The reporting person disclaims beneficial ownership of these securities except to the extent of any pecuniary interest therein. This report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. |
(2) |
Excludes fractional shares that result from conversion of CHESS Depository Interests, which represent 1/20 of one share of common stock of the Issuer, held by entities affiliated with MPM BioVentures IV GP LLC and MPM BioVentures IV LLC. |
(3) |
The securities are held as follows: 184,498 by BV IV, 7,108 by BV KG and 5,246 by AM BV4. The reporting person disclaims beneficial ownership of these securities except to the extent of any pecuniary interest therein. This report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. |
(4) |
The securities are held as follows: 197,699 by BV IV, 7,616 by BV KG and 5,622 by AM BV4. The reporting person disclaims beneficial ownership of these securities except to the extent of any pecuniary interest therein. This report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. |
(5) |
The securities are held as follows: 361,668 by BV IV, 13,933 by BV KG and 10,284 by AM BV4. The reporting person disclaims beneficial ownership of these securities except to the extent of any pecuniary interest therein. This report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. |