UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 12B-25

                                                                 SEC FILE NUMBER
                                                                      0-15489
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                           NOTIFICATION OF LATE FILING

(CHECK ONE):   /X/ FORM 10-K  / / FORM 20-F / / FORM 11-K  / / FORM 10-Q
               / / FORM N-SAR

                                                                  CUSIP NUMBER

                                                                  ------------
                  FOR PERIOD ENDED:    OCTOBER 31, 2000
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                  [   ] TRANSITION REPORT ON FORM 10-K
                  [   ] TRANSITION REPORT ON FORM 20-F
                  [   ] TRANSITION REPORT ON FORM 11-K
                  [   ] TRANSITION REPORT ON FORM 10-Q

                  [   ] TRANSITION REPORT ON FORM N-SAR
                  FOR THE TRANSITION PERIOD ENDED:_______________________

  READ INSTRUCTION (ON BACK PAGE) BEFORE PREPARING FORM. PLEASE PRINT OR TYPE.
    NOTHING IN THIS FORM SHALL BE CONSTRUED TO IMPLY THAT THE COMMISSION HAS
                   VERIFIED ANY INFORMATION CONTAINED HEREIN.

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If the notification relates to a portion of the filing check above, identify the
Item(s) to which the notification relates:

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PART I - REGISTRANT INFORMATION

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Full Name of Registrant
QUEST BIOTECHNOLOGY, INC.
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Former Name if Applicable

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321 FISHER BUILDING, 3011 WEST GRAND BLVD.
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Address of Principal Executive Office (Street and Number)

DETROIT, MICHIGAN 48202
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City, State and Zip Code

PART II  -  RULES 12B-25(B) AND (C)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate) / X /

     (a) The reasons described in reasonable detail in Part III of this form
         could not be eliminated without unreasonable effort or expense;

     (b) The subject annual report, semi-annual report, transition report on
         Form 10-K, Form 20-F, Form 11-K, Form N-SAR, or portion thereof, will
         be filed on or before the fifteenth calendar day following the
         prescribed due date; or the subject quarterly report of transition
         report on Form 10-Q, or portion thereof will be filed on or before the
         fifth calendar day following the prescribed due date; and

     (c) The accountant's statement or other exhibit required by Rule 12b-25(c)
         has been attached if applicable.

PART III - NARRATIVE

State below in reasonable detail the reasons why the Form 10-K, 11-K, 10-Q,
N-SAR, or the transition report or portion thereof, could not be filed within
the prescribed time period. (ATTACH EXTRA SHEETS IF NEEDED)

QUEST BIOTECHNOLOGY, INC. IS UNABLE TO COMPLETE AND VERIFY THE INFORMATION
REQUIRED TO BE CONTAINED IN ITS FORM 10-K FOR THE FISCAL YEAR ENDED OCTOBER 31,
2000 BY JANUARY 29, 2001.




                                                (ATTACH EXTRA SHEETS IF NEEDED)

PART IV - OTHER INFORMATION

(1)  Name and telephone number of person to contact in regard to this
     notification

         LORNA M. O. ANDERSON            (313)                873-0200
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         (Name)                      (Area Code)         (Telephone Number)

(2)  Have all other periodic reports required under Section 13 or 15(d) of the
     Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
     of 1940 during the preceding 12 months (or for such shorter) period that
     the registrant was required to file such reports) been filed? If answer is
     no, identify report(s).
                                                              /X/ Yes  /  / No
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(3)  Is it anticipated that any significant change in results of operations from
     the corresponding period for the last fiscal year will be reflected by the
     earnings statements to be included in the subject report or portion
     thereof?
                                                              /  / Yes  /X/ No

     If so, attach an explanation of the anticipated change, both narratively
     and quantitatively, and. If appropriate, state the reasons why a reasonable
     estimate of the results cannot be made.

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                            QUEST BIOTECHNOLOGY, INC.
                           --------------------------
                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.


Date:  January 29, 2001         By: /S/ LORNA M. O. ANDERSON
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                                CHIEF FINANCIAL OFFICER

INSTRUCTION: The form may be signed by an executive officer of the registrant or
by any other duly authorized representative. The name and title of the person
signing the form shall be typed or printed beneath the signature. If the
statement is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with this form.

                                    ATTENTION
   INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE FEDERAL CRIMINAL
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                        VIOLATIONS (SEE 18 U.S.C. 1001.)
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                              GENERAL INSTRUCTIONS

1.       This form is required by Rule 12b-25 (17 CFR 240.12b-25) of the General
         Rules and Regulations under the Securities Exchange Act of 1934.
2.       One signed original and four conformed copies of this form and
         amendments thereto must be completed and filed with the Securities and
         Exchange Commission, Washington, D.C. 20549, in accordance with Rule
         0-3 of the General Rules and Regulations under the Act. The information
         contained in or filed with the form will be made a matter of public
         record in the Commission files.
3.       A manually signed copy of the form and amendments thereto shall be
         filed with each national securities exchange on which any class of
         securities of the registrant is registered.
4.       Amendments to the notifications must also be filed on form 12b-25 but
         need not restate information that has been correctly furnished. The
         form shall be clearly identified as an amendment notification.