United States
                       Securities and Exchange Commission
                             WASHINGTON, D.C. 20549


                                  Schedule 13G
                               (Amendment No. __)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                                  CUTERA, INC.
             ------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
             ------------------------------------------------------
                         (Title of Class of Securities)

                                    232109108
             ------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2004
             ------------------------------------------------------
             (Date of Event That Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

         |_|      Rule 13d-1(b)

         |X|      Rule 13d-1(c)

         |_|      Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).







                                                  
CUSIP No.  232109108                                                                     Page 2 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Partners
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,000,000
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,000,000
                                                              Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,000,000         Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.13%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IA
-------------------------------------------------------------------------------------------------------------------

                                        *SEE INSTRUCTION BEFORE FILLING OUT!






                                                  
CUSIP No. 232109108                                                                     Page 3 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta California Partners II, L. P.
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,000,000
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,000,000
                                                              Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,000,000         Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.13%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  PN
-------------------------------------------------------------------------------------------------------------------





                                                  
CUSIP No. 232109108                                                                      Page 4 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta California Management Partners II, LLC
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,000,000
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,000,000
                                                              Please see Attachment A

-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,000,000         Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.13%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO
-------------------------------------------------------------------------------------------------------------------








                                                  
CUSIP No. 232109108                                                                      Page 5 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Embarcadero Partners II, LLC
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
   (3)    SEC Use Only


-------------------------------------------------------------------------------------------------------------------
   (4)    Citizenship or Place of Organization

         California
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,000,000
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,000,000
                                                              Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,000,000         Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.13%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO
-------------------------------------------------------------------------------------------------------------------





                                                  
CUSIP No. 232109108                                                                      Page 6 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Guy Nohra
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         30,000
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,000,000
                                                              Please see Attachment A & Footnote 1
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    30,000

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,000,000
                                                              Please see Attachment A & Footnote 1

-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,030,000                  Please see Attachment A  & Footnote 1
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.40%             Please see Attachment A & Footnote 1
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
-------------------------------------------------------------------------------------------------------------------

                                        *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 1: Includes 987,524 shares  beneficially owned by Alta California Partners II, L.P., 12,476 shares owned by
Alta Embarcadero Partners II, LLC, and Stock Options for 30,000 shares of Common Stock held by Guy Nohra. Please see
Attachment A.







                                                  
CUSIP No. 232109108                                                                      Page 7 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Jean Deleage
-------------------------------------------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,000,000
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,000,000
                                                              Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,000,000    Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.13%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
-------------------------------------------------------------------------------------------------------------------

                                        *SEE INSTRUCTION BEFORE FILLING OUT!






                                                  
CUSIP No. 232109108                                                                      Page 8 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Garrett Gruener
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,000,000
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,000,000
                                                              Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,000,000         Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.13%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!








                                                  
CUSIP No. 232109108                                                                      Page 9 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Daniel Janney
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       987,524
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  987,524
                                                              Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         987,524  Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.01%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!






                                                  
CUSIP No. 232109108                                                                      Page 10 of 16 Pages
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alix Marduel
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       987,524
                                                              Please see Attachment A
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  987,524
                                                              Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         987,524  Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         9.01%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!






Item 1.

(a) Name of Issuer: Cutera, Inc. ("Issuer")

(b) Address of Issuer's Principal Executive Offices:

                  3240 Bayshore Blvd.
                  Burlingame, CA 94005


Item 2.

(a) Name of Person Filing:

         Alta Partners ("AP")
         Alta California Partners II, L.P. ("ACPII")
         Alta California Management Partners II, LLC ("ACMPII")
         Alta Embarcadero Partners II, LLC ("AEPII")
         Jean Deleage ("JD")
         Garrett Gruener ("GG")
         Daniel Janney ("DJ")
         Alix Marduel ("AM")
         Guy Nohra ("GN")

 (b) Address of Principal Business Office:

         One Embarcadero Center, Suite 4050
         San Francisco, CA  94111

 (c) Citizenship/Place of Organization:


         Entities:         AP               California
                           ACPII            Delaware
                           ACMPII           Delaware
                           AEPII            California


         Individuals:      JD               United States
                           GG               United States
                           DJ               United States
                           AM               United States
                           GN               United States


(d) Title of Class of Securities: Common Stock

(e) CUSIP Number: 232109108

Item 3.  Not applicable.




Item 4         Ownership.
                             Please see Attachment A


------- ------------------ ----------- ----------- ------------ ----------- -------------
                               AP        ACPII       ACMPII       AEPII          GN
------- ------------------ ----------- ----------- ------------ ----------- -------------
                                                           
(a)     Beneficial         1,000,000   1,000,000    1,000,000   1,000,000    1,030,000
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- -------------
(b)     Percentage of        9.13%       9.13%        9.13%       9.13%        9.40%
        Class
------- ------------------ ----------- ----------- ------------ ----------- -------------
(c)     Sole Voting Power     -0-         -0-          -0-         -0-         30,000
------- ------------------ ----------- ----------- ------------ ----------- -------------
        Shared Voting      1,000,000   1,000,000    1,000,000   1,000,000    1,000,000
        Power
------- ------------------ ----------- ----------- ------------ ----------- -------------
        Sole Dispositive      -0-         -0-          -0-         -0-         30,000
        Power
------- ------------------ ----------- ----------- ------------ ----------- -------------
        Shared             1,000,000   1,000,000    1,000,000   1,000,000    1,000,000
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- -------------
                               JD          GG          DJ           AM
------- ------------------ ----------- ----------- ------------ ----------- -------------
(a)     Beneficial         1,000,000   1,000,000     987,524     987,524
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- -------------
(b)     Percentage of        9.13%       9.13%        9.01%       9.01%
        Class
------- ------------------ ----------- ----------- ------------ ----------- -------------
(c)     Sole Voting Power     -0-         -0-          -0-        -0-
------- ------------------ ----------- ----------- ------------ ----------- -------------
        Shared Voting      1,000,000   1,000,000     987,524     987,524
        Power
------- ------------------ ----------- ----------- ------------ ----------- -------------
        Sole Dispositive      -0-         -0-          -0-         -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- -------------
        Shared             1,000,000   1,000,000     987,524     987,524
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- -------------


Item 5.        Ownership of Five Percent or Less of a Class

Not Applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person

Not applicable.

Item 7.        Identification and Classification of the Subsidiary Which
               Acquired the Security Being Reported on By the Parent Holding
               Company.

Not applicable.

Item 8.        Identification and Classification of Members of the Group

No reporting person is a member of a group as defined in Section
240.13d-1(b)(1)(ii)(H) of the Act.

Item 9.        Notice of Dissolution of Group

Not applicable.

Item 10.       Certification

By signing below we certify that, to the best of our knowledge and belief, the
securities referred to above were acquired and are held in the ordinary course
of business and were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.

EXHIBITS

A:       Joint Filing Statement





                                    Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Date:    February 3, 2005



                                                  
ALTA PARTNERS                                             ALTA CALIFORNIA PARTNERS II, L.P.

                                                          By:  Alta California Management Partners II, LLC,
                                                                       Its General Partner

By:      /s/ Jean Deleage                                     By:               /s/ Guy Nohra                  .
   -----------------------------------------                  -----------------------------------------------
         Jean Deleage, President                              Guy Nohra, Member


ALTA CALIFORNIA MANAGEMENT PARTNERS II, LLC                   ALTA EMBARCADERO PARTNERS II, LLC



By:      /s/ Guy Nohra                                        By:      /s/ Guy Nohra
   -----------------------------------------                  -----------------------------------------------
         Guy Nohra, Member                                             Guy Nohra, Member


         /s/ Jean Deleage                                             /s/ Guy Nohra
--------------------------------------------                  -----------------------------------------------
         Jean Deleage                                                 Guy Nohra


         /s/ Garrett Gruener                                           /s/ Alix Marduel
--------------------------------------------                  -----------------------------------------------
         Garrett Gruener                                               Alix Marduel


         /s/ Daniel Janney
--------------------------------------------
         Daniel Janney




                                    EXHIBIT A

                            AGREEMENT OF JOINT FILING



Date:    February 3, 2005


                                    Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.




                                                  
ALTA PARTNERS                                             ALTA CALIFORNIA PARTNERS II, L.P.

                                                          By:  Alta California Management Partners II, LLC,
                                                                       Its General Partner

By:      /s/ Jean Deleage                                 By:               /s/ Guy Nohra                  .
   -----------------------------------------                  -----------------------------------------------
         Jean Deleage, President                              Guy Nohra, Member


ALTA CALIFORNIA MANAGEMENT PARTNERS II, LLC                   ALTA EMBARCADERO PARTNERS II, LLC



By:      /s/ Guy Nohra                                        By:      /s/ Guy Nohra
   -----------------------------------------                     --------------------------------------------
         Guy Nohra, Member                                             Guy Nohra, Member


         /s/ Jean Deleage                                             /s/ Guy Nohra
--------------------------------------------                  -----------------------------------------------
         Jean Deleage                                                 Guy Nohra


         /s/ Garrett Gruener                                           /s/ Alix Marduel
--------------------------------------------                  -----------------------------------------------
         Garrett Gruener                                               Alix Marduel


         /s/ Daniel Janney
--------------------------------------------
         Daniel Janney




                                  Attachment A


Alta Partners provides  investment  advisory services to several venture capital
funds including Alta California Partners II, L.P. and Alta Embarcadero  Partners
II, LLC. Alta California  Partners II, L.P.  beneficially owns 987,524 shares of
Common  Stock and Alta  Embarcadero  Partners II, LLC  beneficially  owns 12,476
shares of Common  Stock.  The  respective  general  partners and members of Alta
California Partners II, L.P. and Alta Embarcadero Partners II, LLC exercise sole
voting and investment power in respect to the shares owned by such funds.

Certain  principals of Alta Partners are members of Alta  California  Management
Partners  II, LLC (which is a general  partner of Alta  California  Partners II,
L.P.) and  members of Alta  Embarcadero  Partners  II,  LLC.  As members of such
entities,  they may be deemed to share  voting and  investment  powers  over the
shares held by such funds. The principals of Alta Partners  disclaim  beneficial
ownership of all such shares held by the foregoing  funds,  except to the extent
of their proportionate pecuniary interests therein.

Mr. Guy Nohra,  Director, is a member of Alta California Management Partners II,
LLC (which is the general  partner of Alta  California  Partners II, L.P.) and a
member of Alta Embarcadero Partners II, LLC. Thus he currently shares voting and
dispositive powers over the 987,524 shares of Common Stock beneficially owned by
Alta California  Partners II, L.P. and the 12,476 shares  beneficially  owned by
Alta Embarcadero Partners II, LLC. He disclaims beneficial ownership of all such
shares held by the  foregoing  funds  except to the extent of his  proportionate
pecuniary  interests therein. He holds Stock Options for 30,000 shares of Common
Stock granted on 5/10/2004 that will vest  one-third  annually over a three year
period and will expire on 5/10/2014.

Mr. Jean  Deleage is a member of Alta  California  Management  Partners  II, LLC
(which is the general partner of Alta California Partners II, L.P.) and a member
of Alta  Embarcadero  Partners  II, LLC.  Thus he  currently  shares  voting and
dispositive powers over the 987,524 shares of Common Stock beneficially owned by
Alta California  Partners II, L.P. and the 12,476 shares  beneficially  owned by
Alta Embarcadero Partners II, LLC. He disclaims beneficial ownership of all such
shares held by the  foregoing  funds  except to the extent of his  proportionate
pecuniary interests therein.

Mr. Garrett Gruener is a member of Alta California  Management  Partners II, LLC
(which is the general partner of Alta California Partners II, L.P.) and a member
of Alta  Embarcadero  Partners  II, LLC.  Thus he  currently  shares  voting and
dispositive powers over the 987,524 shares of Common Stock beneficially owned by
Alta California  Partners II, L.P. and the 12,476 shares  beneficially  owned by
Alta Embarcadero Partners II, LLC. He disclaims beneficial ownership of all such
shares held by the  foregoing  funds  except to the extent of his  proportionate
pecuniary interests therein.

Daniel Janney is a member of Alta California  Management Partners II, LLC (which
is the general partner of Alta California  Partners II, L.P.). Thus he currently
shares  voting and  dispositive  powers over the 987,524  shares of Common Stock
beneficially owned by Alta California Partners II, L.P. He disclaims  beneficial
ownership of all such shares held by the foregoing funds except to the extent of
his proportionate pecuniary interests therein.

Dr. Alix  Marduel is a member of Alta  California  Management  Partners  II, LLC
(which is the general  partner of Alta California  Partners II, L.P.).  Thus she
currently shares voting and dispositive powers over the 987,524 shares of Common
Stock  beneficially  owned by Alta  California  Partners II, L.P. She  disclaims
beneficial  ownership of all such shares held by the  foregoing  funds except to
the extent of her proportionate pecuniary interests therein.

Alta Partners is a venture  capital firm with an office in San  Francisco.  Alta
Partners is  California  Corporation.  Alta  California  Partners  II, L.P. is a
Delaware  Limited  Partnership,  and  Alta  Embarcadero  Partners  II,  LLC is a
California Limited Liability Company.