a_bankthrift.htm

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED
MANAGEMENT INVESTMENT COMPANIES

Investment Company Act file number 811- 8568

John Hancock Bank and Thrift Opportunity Fund
(Exact name of registrant as specified in charter)

601 Congress Street, Boston, Massachusetts 02210
(Address of principal executive offices) (Zip code)

Alfred P. Ouellette, Senior Attorney & Assistant Secretary

601 Congress Street

Boston, Massachusetts 02210
(Name and address of agent for service)

Registrant's telephone number, including area code:  617-663-4324 

Date of fiscal year end:
 
October  31 
 
Date of reporting period:  July 31,  2006 

ITEM 1. SCHEDULE OF INVESTMENTS




John Hancock
Bank and Thrift Opportunity Fund
Securities owned by the Fund on
July 31, 2006 (unaudited)

    Interest  Maturity  Credit  Par value   
Issuer, description    rate (%)  date  rating (A)  ($000)  Value 

 
Bonds 0.08%            $846,230 
(Cost $770,000)             
 
Regional Banks 0.08%            846,230 

CSBI Capital Trust I,             
Gtd Sub Cap Inc Ser A (B)(G)    11.750  06-06-27  B-  770  846,230 
 
Issuer          Shares  Value 

 
Common stocks 88.76%            $884,819,617 
(Cost $405,261,046)             
 
Asset Management & Custody Banks  3.06%          30,542,790 

Bank of New York Co., Inc. (The) (NY)          305,000  10,251,050 
Mellon Financial Corp. (PA)          330,000  11,550,000 
Northern Trust Corp. (IL)          70,000  3,997,000 
State Street Corp. (MA)          79,000  4,744,740 
 
Consumer Finance 0.55%            5,486,358 

Capital One Financial Corp. (VA) (L)          70,929  5,486,358 
 
Diversified Banks 11.15%            111,111,296 

Comerica, Inc. (MI)          384,400  22,506,620 
Toronto-Dominion Bank (The) (Canada)          130,349  6,680,386 
U.S. Bancorp. (MN)          805,541  25,777,312 
Wachovia Corp. (NC) (L)          507,571  27,221,033 
Wells Fargo & Co. (CA)          399,861  28,925,945 
 
Other Diversified Financial Services  6.36%          63,364,525 

Bank of America Corp. (NC)          534,260  27,530,418 
Citigroup, Inc. (NY)          415,925  20,093,337 
JPMorgan Chase & Co. (NY)          345,041  15,740,770 
 
Regional Banks 62.91%            627,136,980 

Access National Corp. (VA)          250,000  2,325,000 
Alabama National Bancorp. (AL)          152,000  10,298,000 
AmericanWest Bancorp. (WA)          357,921  7,623,717 
Ameris Bancorp. (GA)          78,480  2,001,240 
AmSouth Bancorp. (AL)          95,879  2,747,892 
BB&T Corp. (NC)          344,846  14,480,084 
Beverly National Corp. (MA)          97,500  2,340,000 
BOK Financial Corp. (OK)          117,208  6,028,007 
Cadence Financial Corp. (MS)          100,500  2,106,480 
Camden National Corp. (ME)          140,000  6,244,000 
Capital City Bank Group, Inc. (FL) (L)          74,543  2,421,157 

Page 1


John Hancock

Bank and Thrift Opportunity Fund

Securities owned by the Fund on July 31, 2006 (unaudited)

Cascade Bancorp. (OR) (L)  184,272  6,355,541 
Chittenden Corp. (VT)  230,245  6,497,514 
City Holding Co. (WV)  41,600  1,612,000 
City National Corp. (CA) (L)  243,377  16,235,680 
CoBiz, Inc. (CO)  63,200  1,483,304 
Colonial BancGroup, Inc. (The) (AL)  589,700  14,978,380 
Commercial Bankshares, Inc. (FL) (L)  63,702  2,229,570 
Community Banks, Inc. (PA) (L)  110,307  2,854,745 
Compass Bancshares, Inc. (AL)  439,857  25,925,172 
Cullen/Frost Bankers, Inc. (TX)  20,000  1,174,400 
Dearborn Bancorp., Inc. (MI) (I)  75,993  1,741,000 
Desert Community Bank (CA)  275,000  5,024,250 
DNB Financial Corp. (PA)  72,577  1,524,117 
East West Bancorp., Inc. (CA) (L)  435,000  17,552,250 
ECB Bancorp., Inc. (NC)  65,000  2,168,400 
Eurobancshares, Inc. (Puerto Rico) (I)  42,830  406,457 
F.N.B. Corp. (PA)  90,049  1,489,410 
Fifth Third Bancorp. (OH)  304,040  11,596,086 
Financial Institutions, Inc. (NY)  73,000  1,470,220 
First Charter Corp. (NC)  91,700  2,162,286 
First Horizon National Corp. (TN) (L)  152,150  6,375,085 
First Midwest Bancorp., Inc. (IL)  103,800  3,705,660 
First National Lincoln Corp. (ME)  146,499  2,600,357 
First Regional Bancorp. (CA) (I)  150,000  14,821,500 
First State Bancorp. (NM)  130,000  3,170,700 
Fulton Financial Corp. (PA)  359,890  5,956,179 
Glacier Bancorp., Inc. (MT)  370,288  11,345,624 
Harleysville National Corp. (PA)  144,664  3,040,837 
Independent Bank Corp. (MI)  328,510  8,413,141 
International Bancshares Corp. (TX)  200,337  5,803,763 
KeyCorp (OH) (L)  297,000  10,959,300 
M&T Bank Corp. (NY) (L)  166,657  20,318,821 
Marshall & Ilsley Corp. (WI) (L)  529,295  24,860,986 
MB Financial, Inc. (IL) (L)  152,950  5,438,902 
Mercantile Bankshares Corp. (MD)  314,250  11,174,730 
Merrill Merchants Bankshares, Inc. (ME)  78,173  1,867,553 
Mid-State Bancshares (CA)  50,000  1,349,500 
National City Corp. (OH) (L)  466,587  16,797,132 
North Fork Bancorp., Inc. (NY)  701,592  19,876,101 
Northrim Bancorp., Inc. (AK)  70,053  1,733,812 
Pacific Capital Bancorp. (CA)  364,354  10,733,869 
Placer Sierra Bancshares (CA)  14,550  317,045 
PNC Financial Services Group, Inc. (PA)  353,100  25,013,604 
Prosperity Bancshares, Inc. (TX)  158,745  5,583,062 
Provident Bankshares Corp. (MD)  175,058  6,436,883 
Regions Financial Corp. (AL)  177,390  6,437,483 
S&T Bancorp., Inc. (PA)  154,700  4,837,469 
SCBT Financial Corp. (SC)  5,100  192,627 
Security Bank Corp. (GA) (L)  197,500  4,471,400 
Sky Financial Group, Inc. (OH)  309,850  7,600,621 
Smithtown Bancorp., Inc. (NY) (L)  45,000  1,198,800 
South Financial Group, Inc. (The) (SC)  70,150  1,895,453 
Southcoast Financial Corp. (SC) (I)(L)  44,990  949,289 
Summit Bancshares, Inc. (TX)  279,000  7,834,320 

Page 2


John Hancock
Bank and Thrift Opportunity Fund
Securities owned by the Fund on
July 31, 2006 (unaudited)

Summit Bank Corp. (GA)  135,000  2,181,613 
SunTrust Banks, Inc. (GA) (L)  322,826  25,461,287 
SVB Financial Group (DE) (I)(L)  160,850  7,209,297 
Synovus Financial Corp. (GA)  615,350  17,389,791 
Taylor Capital Group, Inc. (IL)  241,950  7,638,361 
TCF Financial Corp. (MN)  412,666  11,104,842 
TD Banknorth, Inc. (ME) (L)  309,517  8,975,993 
Texas Regional Bancshares, Inc. (Class A) (TX)  110,000  4,170,100 
TriCo Bancshares (CA)  53,000  1,315,990 
UCBH Holdings, Inc. (CA)  402,500  6,713,700 
Umpqua Holdings Corp. (OR) (L)  182,901  4,771,887 
UnionBanCal Corp. (DE)  134,000  8,279,860 
Univest Corp. (PA)  205,218  6,002,626 
Valley National Bancorp. (NJ) (L)  100,255  2,603,622 
Vineyard National Bancorp Co. (CA)  283,970  7,917,084 
Virginia Financial Group, Inc. (VA)  45,500  1,911,000 
West Coast Bancorp. (OR)  67,583  2,050,468 
Westamerica Bancorp. (CA) (L)  40,000  1,924,400 
Whitney Holding Corp. (LA)  150,750  5,440,567 
Wilmington Trust Corp. (DE)  350,000  15,242,500 
Yardville National Bancorp. (NJ)  97,400  3,377,832 
Zions Bancorp. (UT)  356,053  29,246,193 
 
Thrifts & Mortgage Finance 4.73%    47,177,668 

Astoria Financial Corp. (NY)  80,865  2,405,734 
BankUnited Financial Corp. (Class A) (FL)  56,650  1,676,274 
Benjamin Franklin Bancorp., Inc. (MA)  15,000  209,250 
Berkshire Hills Bancorp., Inc. (DE)  74,110  2,585,698 
Countrywide Financial Corp. (CA) (L)  186,500  6,682,295 
Freddie Mac (VA)  47,450  2,745,457 
Hingham Institute for Savings (MA)  80,000  3,000,800 
Hudson City Bancorp., Inc. (NJ) (L)  383,810  4,978,016 
LSB Corp. (MA)  65,000  1,088,750 
NewAlliance Bancshares, Inc. (CT)  12,581  177,518 
PennFed Financial Services, Inc. (NJ)  313,600  5,663,616 
Sovereign Bancorp., Inc. (PA)  113,400  2,340,576 
Washington Mutual, Inc. (WA)  230,812  10,317,296 
Webster Financial Corp. (CT)  70,110  3,306,388 

    Interest  Par value   
Issuer, description, maturity date    rate (%)  ($000)  Value 

 
Short-term investments  11.16%      $111,246,322 
(Cost $111,246,322)         
 
Certificates of Deposit 0.01%        80,826 

Deposits in mutual banks      81  80,826 
Joint Repurchase Agreement 1.37%      13,688,000 

Investment in a joint repurchase agreement       
transaction with Morgan Stanley - Dated 7-31-06       
due 8-01-06 (Secured by U.S. Treasury Inflation       
Indexed Bond 3.625% due 4-15-28)    5.250  13,688  13,688,000 

Page 3


John Hancock
Bank and Thrift Opportunity Fund
Securities owned by the Fund on
July 31, 2006 (unaudited)

    Shares   
Cash Equivalents 9.78%      97,477,496 

AIM Cash Investment Trust (T)    97,477,496  97,477,496 
Total investments  100.00%    $996,912,169 

Page 4


John Hancock
Bank and Thrift Opportunity Fund
Footnotes to Schedule of Investments
July 31, 2006 (unaudited)

(B) This security is fair valued in good faith under procedures established by the Board of Trustees.

(G) Security rated internally by John Hancock Advisers, LLC.

(I) Non-income-producing security.

(L) All or a portion of this security is on loan as of July 31, 2006.

(T) Represents investment of securities lending collateral.

Parenthetical disclosure of a foreign country in the security description represents country of a foreign issuer.

The percentage shown for each investment category is the total value of that category as a percentage of the total investment of the Fund.

The cost of investments owned on July 31, 2006, including short-term investments, was $517,277,368. Gross unrealized appreciation and depreciation of investments aggregated $481,231,382 and $1,596,581, respectively, resulting in net unrealized appreciation of $479,634,801.

Footnotes to Schedule of Investments - Page 1





ITEM 2. CONTROLS AND PROCEDURES.

(a) Based upon their evaluation of the registrant's disclosure controls and procedures as conducted within 90 days of the filing date of this Form N-Q, the registrant's principal executive officer and principal financial officer have concluded that those disclosure controls and procedures provide reasonable assurance that the material information required to be disclosed by the registrant on this report is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission's rules and forms.

(b) There were no changes in the registrant's internal control over financial reporting that occurred during the registrant's last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting.

ITEM 3. EXHIBITS.

Separate certifications for the registrant's principal executive officer and principal financial officer, as required by Rule 30a-2(a) under the Investment Company Act of 1940, are attached.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

John Hancock Bank and Thrift Opportunity Fund

By: /s/ Keith F. Hartstein
-------------------------------------
Keith F. Hartstein
President and Chief Executive Officer

Date: September 26, 2006

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By: /s/ Keith F. Hartstein
-------------------------------------
Keith F. Hartstein
President and Chief Executive Officer

Date: September 26, 2006

By: /s/ John G. Vrysen
-------------------------------------
John G. Vrysen
Executive Vice President and Chief Financial Officer

Date: September 26, 2006