================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                   F O R M 6-K

       REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                          For the month of March 2003

                           Prana Biotechnology Limited
                              (Name of Registrant)


      Level 1, 100 Dorcas Street, South Melbourne, Victoria 3205 Australia
                     (Address of Principal Executive Office)

     Indicate  by check mark  whether the  registrant  files or will file annual
reports under cover of Form 20-F or Form 40-F.

                             Form 20-F   [X]    Form 40-F      [ ]

     Indicate  by check mark if the  registrant  is  submitting  the Form 6-K in
paper as permitted by Regulation S-T Rule 101(b)(1):

     Indicate  by check mark if the  registrant  is  submitting  the Form 6-K in
paper as permitted by Regulation S-T Rule 101(b)(7):

     Indicate by check mark whether by furnishing the  information  contained in
this Form,  the  registrant is also thereby  furnishing  the  information to the
Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

                                        Yes   [ ]   No   [X]

     If  "Yes"  is  marked,  indicate  below  the file  number  assigned  to the
registrant in connection with Rule 12g3-2(b): 82- ___________________

================================================================================





                           PRANA BIOTECHNOLOGY LIMITED

6-K Items

1.   Prana Biotechnology  Limited Appendix 4B Interim Financial Report for the 6
     months ended December 31, 2002 dated March 13, 2003.


2.   Prana  Biotechnology  Limited  new  issue  announcement,   application  for
     quotation of additional securities and agreement dated March 13, 2003.






                                                                          ITEM 1






                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------



                       [GRAPHIC OMITTED][GRAPHIC OMITTED]

                          PRANA BIO TECHNOLOGY LIMITED
                               ABN 37 080 699 065


                            INTERIM FINANCIAL REPORT
                                31 December 2002

                                DIRECTORS' REPORT

The Directors of Prana Biotechnology Limited herewith submit the financial
report for the six months ended 31 December 2002. In order to comply with the
Corporations Act 2001, the Directors' report as follows:

DIRECTORS

The names of Directors who held office during or since the end of the financial
year are:

Geoffrey Kempler,          Executive Chairman                 11 November 1997
Professor Colin Masters,   Executive Director                 9 December 1999
Brian Meltzer,             Non-Executive Director             9 December 1999
George Mihaly,             Non-Executive Director             9 December 1999


THE RESULT

The  operating  loss for the  Company for the half year  amounted to  $3,138,115
(prior half year loss $2,533,922)


REVIEW OF OPERATIONS

The Chairman and senior staff recently  prepared a presentation  to shareholders
covering  achievements  to date,  goals for the current year and the outlook for
2003, an extract of the presentation is included below.

Overview

The three main points made at the presentation are:

1.   Through  preclinical  and  clinical  proof of concept  studies,  MPACs have
     established  themselves as a revolutionary and exciting strategy to address
     neurodegenerative diseases.

2.   Our  findings  have  been   scrutinised  and  embraced  by  several  global
     Pharmaceutical companies who are keenly negotiating with Prana to establish
     ongoing collaborations.

3.   We  have a  significant  head  start  in the  development  of  intellectual
     property to drive value into the hands of shareholders.


--------------------------------------------------------------------------------
                                                                   Page 1 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


Extract of the Executive Chairman's presentation

Let me begin with a recap of the overall goals and purpose of the company. Prana
was  established  to develop drugs to treat the underlying  toxicity  associated
with aggregating proteins in the brain, beginning with Alzheimer's disease (AD).
We have  evidence  that our approach will help with a broad range of other major
neurodegenerative disorders. The toxicity is a consequence of this metal protein
interaction.  Therefore our therapeutic  strategy has been to develop drugs that
attenuate  this  activity  between  metals and  proteins - a class of  molecules
called MPAC's (metal-protein attenuating compounds).

The ideal drug for an AD patient would have 3 qualities:

     1. Treat the symptoms - improve cognition in patients;

     2. Treat the cause - address the underlying pathology of the disease; and,

     3. Be suitable for long term use.

Current  drugs on the market only  partially  arrest the symptoms over a limited
period  of time,  but do not stop the  inexorable  progression  of the  disease.
Nonetheless, even these drugs have combined sales of about a billion dollars.

So what is the hope for  Prana's  MPAC  drugs?  Prana's  aim has always  been to
develop the ideal drug that goes beyond  existing  drugs.  Initially we selected
Clioquinol, an existing compound with MPAC attributes, to provide clinical proof
of concept.  To test this we designed a small  clinical trial and the results of
the trial  strengthen  our belief  that MPAC's  have the  potential  not only to
benefit cognition but also to positively  influence the underlying causes of the
pathology of the disease.

These  results  have  been  shared,  in  confidence,  with  a  select  group  of
international  Pharmaceutical companies who have independently reviewed both the
scientific and clinical data and have provided us with independent  confirmation
of the  validity  of the  therapeutic  approach.  Their  enthusiastic  responses
provide us with the  confidence  to predict  that the company  will enter into a
significant collaboration with a suitable pharmaceutical company.

Share price and cash position

Let me comment on the recent share trading in Prana and our cash position. Prana
has raised a total of A$13million from the public to develop the company to this
point.  At the  time of the  original  IPO in  Australia,  back in  March  2000,
original investors who subscribed for fully paid ordinary shares also received a
1:2 attaching Option to purchase an additional share in the company, exercisable
at 50 cents  before  the 1st of March  this  year.  In the US  Options  are more
commonly  know as Warrants.  Investors  have always been  cogniscent  that these
Options would be exercised and converted into shares. Accordingly the conversion
of these  Options has always been  anticipated  in  considering  the  underlying
market  capitalisation  of  the  company.  It is  important  to  note  that  the
conversion of these Options does not have a new dilutionary effect of the market
capitalisation  of the  company.  The Company will  receive  approximately  $3.5
million from the conversion of these Options,  which is fully  underwritten.  We
believe the recent  selling in Prana shares has arisen from some Option  holders
having to sell a portion of their  fully  paid  shares to fund the  exercise  of
their Options. Naturally, this pressure will be eliminated from March 1 onwards.

With regard to cash, this injection of $3.5 million, in addition to our existing
$1.4 million in cash and assured receipts from existing Grants, provides us with
operating funds for over a year. Further funding opportunities are under
evaluation for the period beyond that.


--------------------------------------------------------------------------------
                                                                   Page 2 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


Extract from Chief Operating Officer and head of Drug Development's presentation

Prana  clearly  had an  exciting  and  productive  2002.  Most  notable  was the
completion of the Phase II  "proof-of-concept"  clinical trial with  clioquinol.
The in-life portion of this trial completed in early 2002 with the full analysis
of the data  submitted to a leading peer reviewed  journal in late third quarter
2002.  This  publication was complex and designed to tie together the results of
the  clinical  trial with the  substantial  and  growing  amount of  preclinical
scientific data and theory that supports the MPAC  technology.  It is clear from
the time  elapsed  that it has not been a simple  task to get a paper like this,
with its  broad  clinical  and  preclinical  conclusions,  published.  Using the
feedback  we  have  received  from  editors,  we  are  now  in  the  process  of
reformatting the publication for resubmission.  What I am excited to tell you is
that  multiple  major  Pharmaceutical  companies  have  rigorously  assessed the
clinical  results and the MPAC theory and have,  in their words "bought into the
science"  and remain  very  interested  in entering  into a potential  deal with
Prana. Our back-up and follow-up  chemistry  programs are of special interest to
these  companies  and with almost 300  compounds,  they  provide  any  potential
partner with a large selection of compounds with the appropriate  attributes for
clinical  development.  We  expect  that at least one  partnership  deal will be
concluded  in 2003  and  that  the  potential  exists  for a  further  1 or more
compounds to enter the clinic in 2004.

It is  probably  appropriate  here to spend a few  minutes  clarifying  why "Big
Pharma" finds Prana's MPAC mechanism and portfolio so  interesting.  Clearly the
problem  with  present  Alzheimer's  disease  treatments  is their  inability to
address the  underlying  cause of the  disease.  The market  leading  treatments
appear to  provide  short-lived  symptomatic  relief in the form of a  temporary
slowing in the  decline of  patient's  cognition.  After an initial  improvement
patients  fall back on a similar  decline curve to that seen prior to treatment.
Pranas clinical trial with clioquinol  provided an indication that this class of
compound has the  potential to provide a much more  profound  effect - modifying
disease progression,  changing the fundamental course of the disease.  Whilst it
was very pleasing to show that clioquinol can have a striking and  statistically
significant positive effect on cognition in the more severe patients,  above and
beyond  that of  Aricept  (Pfizer),  it is the  observation  that  an  MPAC  can
positively  affect the  levels of  beta-amyloid  in  patients  with less  severe
disease  that  raises the  possibility  of  disease  modification.  So  although
receiving  less  initial  press,  it is clear to me that it is this later  point
which makes Prana's  portfolio so sought after and commercial  attractive.  This
provides  the  potential  for disease  modification  rather than just  temporary
symptom  relief.  Independent  market analysis has put the sales potential for a
true disease modifying agent in Alzheimer's disease above US$10 billion.

Although Prana's most advanced area of research is Alzheimer's disease, there is
a clear and growing body of new evidence  (much of which is as yet  unpublished)
that the MPAC  platform  technology  has potential in a variety of other serious
diseases.  Prana has, at present,  preclinical data supporting the applicability
of  this  technology  to  other  neurological   diseases  and  diseases  outside
neurology.  Both in-house and collaborative  research programs are being pursued
to exploit the broad applicability of the MPAC platform technology.

In addition to this, Prana scientists are also beginning to develop programs for
the  long-term   treatment  of   Alzheimer's   disease  using  new   proprietary
technologies  other  than the MPAC  platform  and  also to  develop  Alzheimer's
disease diagnostics.

Prana's R&D plan for 2003/04  has been  designed to optimise  the number of uses
for its MPAC  technology  including  the  treatment  of  Alzheimer's  and  other
diseases,  but also to exploit additional  discoveries in Alzheimer's  treatment
and diagnosis. I believe we are on track to meet our 2003 milestones.

Extract from Vice President of Intellectual Property presentation

The company's portfolio covers multiple mechanisms  implicated in the underlying
pathology of  Alzheimer's  Disease and other  neurodegenerative  disorders.  The
MPAC's are directed to several of these mechanisms.

The recently completed clinical trial with clioquinol  validated Prana's work by
showing what MPAC's can do. Prana is the first to recognise  the validity of the
MPAC approach and hence to focus its chemistry expertise on developing a body of
understanding  of which  structures  will best  demonstrate  MPAC activity.  The
discovery of which  structural  components of a compound are responsible for the
desired  pharmacological and therapeutic  outcomes gives Prana a tremendous lead
in developing valuable Intellectual  Property.  For example, an understanding of
what  influences  toxicity,  what  enhances  blood  brain  penetration  and what
attenuates the metal protein  interaction etc.  Indeed,  the discoveries to date
have  been  captured  in 6 new  patent  families,  filed in recent  months.  The
protection sought in each patent application includes MPAC composition of matter
claims,  method of  production  claims and claims to the utility of the MPACs in
the treatment of numerous neurological disorders.

--------------------------------------------------------------------------------
                                                                   Page 3 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


If we look at clioquinol specifically,  Prana's preparedness to settle this well
known patent  dispute will be heavily  influenced by the interests of our future
licensees and their development plans for our MPAC platform.

Our aim is one of  continual  expansion  of our patent  portfolio to protect the
growing  MPAC  technology  platform  and its  application  to  multiple  disease
targets.


Signed in accordance with a resolution of the Board of Directors




/s/Geoffrey Kempler
Geoffrey Kempler
Executive Chairman

Date this 13th day of March 2003






--------------------------------------------------------------------------------
                                                                   Page 4 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------

                                                                 Rules 4.1, 4.3
                                   Appendix 4B

                      Half yearly/preliminary final report

Introduced 30/6/2002.

 Name of entity
 -------------------------------------------------------------------------------
   PRANA BIOTECHNOLOGY LIMITED
 -------------------------------------------------------------------------------

 ABN or equivalent company    Half yearly   Preliminary    Half year/financial
 reference                     (tick)       final (tick)   year ended (`current
                                                           period')
 ----------------------------  --------      --------      -----------------
         37 080 699 065           X                        31 December 2002
 ----------------------------  --------      --------      -----------------

For announcement to the market


Extracts from this report for announcement to the market (see note 1).                   $A
-------------------------------------------------------------------------------------------------
                                                                         
Revenues from ordinary activities (item 1.1)                    down           12% to    526,700

Profit (loss) from ordinary activities after tax attributable   up             24% to (3,138,115)
to members (item 1.22)

Profit (loss) from extraordinary items after tax attributable   gain (loss)
to members (item 2.5(d))                                        of

Net profit (loss) for the period attributable to members        up             24% to (3,138,115)
(item 1.11)
-------------------------------------------------------------------------------------------------




-----------------------------------------------------------------------------------------------------------
Dividends (distributions)                                        Amount per security     Franked amount per
                                                                                              security
-----------------------------------------------------------------------------------------------------------
                                                                                          
Final dividend (Preliminary final report only - item 15.4)
Interim dividend (Half yearly report only - item 15.6)                   -(cent)                -(cent)
-----------------------------------------------------------------------------------------------------------
Previous corresponding period (Preliminary final report -
item 15.5; half yearly report  - item 15.7)                              -(cent)                -(cent)
-----------------------------------------------------------------------------------------------------------

                                                           ---------------------
+Record  date  for   determining   entitlements   to  the
dividend,                                                            -
(in the case of a trust, distribution) (see item 15.2)
                                                           ---------------------

Brief explanation of any of the figures reported above (see Note 1) and short
details of any bonus or cash issue or other item(s) of importance not previously
released to the market:
--------------------------------------------------------------------------------


If this is a half yearly report it is to be read in conjunction with the most
recent annual financial report.

--------------------------------------------------------------------------------
                                                                   Page 5 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------



Condensed consolidated statement of financial performance
                                                             -----------------------------------------------
                                                                 Current period       Previous corresponding
                                                                       $A                     period
                                                                                          July - Dec 01
                                                                                                $A
                                                             -----------------------------------------------
                                                                                       
1.1      Revenues from ordinary activities (see items 1.23               526,700                   601,089
         -1.25)

1.2      Expenses from ordinary activities (see items 1.26            (3,664,815)               (3,135,011)
         & 1.27)
1.3       Borrowing costs                                                      -                         -
1.4      Share of net profits (losses) of associates and                       -                         -
         joint venture entities (see item 16.7)
-----------------------------------------------------------------------------------------------------------
1.5      Profit (loss) from ordinary activities before tax            (3,138,115)               (2,533,922)

1.6      Income tax on ordinary activities (see note 4)                        -                         -
-----------------------------------------------------------------------------------------------------------
1.7      Profit (loss) from ordinary activities after tax             (3,138,115)               (2,533,922)

1.8      Profit (loss) from extraordinary items after tax                      -                         -
         (see item 2.5)
-----------------------------------------------------------------------------------------------------------
1.9      Net profit (loss)                                            (3,138,115)               (2,533,922)
1.10     Net profit (loss) attributable to outside +equity
         interests                                                             -                         -
-----------------------------------------------------------------------------------------------------------
1.11     Net profit (loss) for the period attributable to             (3,138,115)               (2,533,922)
         members
-----------------------------------------------------------------------------------------------------------
Non-owner transaction changes in equity

1.12      Increase (decrease) in revaluation reserves                          -                         -
1.13      Net exchange differences recognised in equity                        -                         -
1.14      Other  revenue,  expense and initial  adjustments
          recognised directly in equity (attach details)
          Initial   adjustments   from   UIG   transitional                    -                         -
1.15      provisions                                                           -                         -
-----------------------------------------------------------------------------------------------------------
1.16      Total  transactions  and  adjustments  recognised
          directly in equity (items 1.12 to 1.15)                              -                         -
-----------------------------------------------------------------------------------------------------------
1.17      Total  changes  in  equity  not  resulting   from
          transactions with owners as owners                          (3,138,115)               (2,533,922)
-----------------------------------------------------------------------------------------------------------


                                    --------------------------------------------
                                    Current period       Previous corresponding
 Earnings per security (EPS)                                     period
                                                             July - Dec 01
                                                                   $A
-------------------------------------------------------------------------------
 1.18    Basic EPS                      (5.3 cents)          (4.4 cents)
 1.19    Diluted EPS                    (5.3 cents)          (4.4 cents)
--------------------------------------------------------------------------------


--------------------------------------------------------------------------------
                                                                   Page 6 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------

Notes to the condensed consolidated statement of financial performance

Profit (loss) from ordinary activities attributable to members


                                                             ---------------------------------------------
                                                               Current period       Previous corresponding
                                                                    $A                     period
                                                                                       July - Dec 01
                                                                                             $A
                                                             ----------------------------------------------
                                                                                       
 1.20     Profit (loss) from ordinary  activities after tax           (3,138,115)               (2,533,922)
          (item 1.7)
 1.21     Less (plus) outside +equity interests                                -                         -
-----------------------------------------------------------------------------------------------------------
 1.22     Profit  (loss)  from  ordinary  activities  after           (3,138,115)               (2,533,922)
          tax, attributable to members
-----------------------------------------------------------------------------------------------------------



Revenue and expenses from ordinary activities
(see note 15)
                                                             ----------------------------------------------
                                                              Current period       Previous corresponding
                                                                    $A                     period
                                                                                       July - Dec 01
                                                                                             $A
                                                             ---------------------------------------------
                                                                                       

 1.23     Revenue from sales or services                                       -                         -

 1.24     Interest revenue                                                57,483                   132,089

 1.25     Other relevant revenue - Start Grant                           469,217                   469,000
          -------------------------------------------------------------------------------------------------
                                                                         526,700                   601,089
          -------------------------------------------------------------------------------------------------
 1.26     Details of relevant expenses
          Patents/Research and Development Costs                      (1,447,215)               (1,527,741)
          Consulting Fees                                               (382,278)                 (197,924)
          Legal Fees                                                    (322,772)                 (357,458)
          Wages                                                         (454,866)                 (270,387)
          Corporate Compliance                                          (468,702)                 (203,365)
          Amortisation of Intangibles                                   (550,000)                 (550,001)
          Other                                                                -                         -
                                                                         -------                   -------
          Total item 1.26                                             (3,625,833)               (3,106,876)
 1.27     Depreciation    and    amortisation     excluding              (38,982)                  (28,135)
          amortisation of intangibles (see item 2.3)
          -------------------------------------------------------------------------------------------------
          Total items 1.26 & 1.27                                     (3,664,815)               (3,135,011)
          -------------------------------------------------------------------------------------------------
          Net Profit (Loss) before tax (Item 1.5)                     (3,138,115)               (2,533,922)
 ----------------------------------------------------------------------------------------------------------
 Capitalised outlays
 1.28     Interest costs capitalised in asset values                           -                         -

 1.29     Outlays   capitalised  in   intangibles   (unless                    -                         -
          arising from an +acquisition of a business)
 ----------------------------------------------------------------------------------------------------------



Consolidated retained profits
                                                             ----------------------------------------------
                                                              Current period       Previous corresponding
                                                                    $A                     period
                                                                                       July - Dec 01
                                                                                             $A
                                                             ----------------------------------------------
                                                                                       

1.30     Retained profits (accumulated losses) at the
         beginning of the financial period                           (10,994,424)               (5,545,957)

1.31     Net profit (loss) attributable to members (item              (3,138,115)               (2,533,922)
         1.11)

--------------------------------------------------------------------------------
                                                                   Page 7 of 26

                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------




                                                                                       
1.32     Net transfers from (to) reserves (details if                          -                         -
         material)
1.33     Net effect of changes in accounting policies                          -                         -
1.34     Dividends and other equity distributions paid or                      -                         -
         payable
-----------------------------------------------------------------------------------------------------------
1.35     Retained profits (accumulated losses) at end of             (14,132,539)               (8,079,879)
         financial period
------------------------------------------------------------------------------------------------------------




Intangible and extraordinary items

                                          ------------------------------------------------------------------
                                                            Consolidated - current period
                                          ------------------------------------------------------------------
                                           Before tax      Related tax         Related       Amount (after
                                               $A               $A             outside           tax)
                                                                               +equity       attributable
                                                                              interests       to members
                                               (a)             (b)               $A               $A
                                                                                 (c)              (d)
                                          ------------------------------------------------------------------
                                                                                     
 2.1     Amortisation of goodwill                     -                 -                -                -
 2.2     Amortisation of other                  550,000                 -                -          550,000
         intangibles
                                          ------------------------------------------------------------------
 2.3     Total amortisation of
         intangibles                            550,000                 -                -          550,000
 -----------------------------------------------------------------------------------------------------------
 2.4     Extraordinary items (details)                -                 -                -                -
                                          ------------------------------------------------------------------
 2.5     Total extraordinary items                    -                 -                -                -
 -----------------------------------------------------------------------------------------------------------




                                                          --------------------------------------------------
 Comparison of half year profits                               Current year         Previous corresponding
 (Preliminary final report only)                                    $A                      period
                                                                                        July - Dec 01
                                                                                              $A
                                                          --------------------------------------------------
                                                                                    
 3.1     Consolidated profit (loss) from ordinary                   n/a                      n/a
         activities after tax attributable to members
         reported for the 1st half year (item 1.22 in
         the half yearly report)
                                                          --------------------------------------------------
 3.2     Consolidated profit (loss) from ordinary                   n/a                      n/a
         activities after tax attributable to members
         for the 2nd half year
                                                          --------------------------------------------------


--------------------------------------------------------------------------------
                                                                   Page 8 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------



                                                      -------------------------------------------------------
  Condensed consolidated statement of financial          At end of      As shown in last    As in last half
  position                                            current period    annual report $A   yearly report $A
                                                            $A
                                                      -------------------------------------------------------
                                                                                       
            Current assets
 4.1        Cash                                            1,446,025           3,585,014          5,508,105
 4.2        Receivables                                        60,929             107,936              5,365
 4.3        Investments                                             -                   0                  0
 4.4        Inventories                                             -                   0                  0
 4.5        Tax assets                                              -                   0                  0
 4.6        Other (provide details if material)                50,248              60,367             42,422
                                                      -------------------------------------------------------
 4.7        Total current assets                            1,557,202           3,753,317          5,555,892
 ------------------------------------------------------------------------------------------------------------
            Non-current assets
 4.8        Receivables                                             -                   -                  -
 4.9        Investments (equity accounted)                          -                   -                  -
 4.10       Other investments                                       -                   -                  -
 4.11       Inventories                                             -                   -                  -
 4.12       Exploration and evaluation expenditure
            capitalised (see para .71 of AASB 1022)                 -
                                                                                        -                  -
 4.13       Development properties (+mining                         -
            entities)                                                                   -                  -
 4.14       Other property, plant and equipment
            (net)                                             188,483             139,653            159,163
 4.15       Intangibles (net)                              13,138,349          13,688,349         14,238,351
 4.16       Tax assets                                              -                   -                  -
 4.17       Other (provide details if material)                     -                   -                  -
                                                      -------------------------------------------------------
 4.18       Total non-current assets                       13,326,832          13,828,002         14,397,514
 ------------------------------------------------------------------------------------------------------------
 4.19       Total assets                                   14,884,034          17,581,319         19,953,406
 ------------------------------------------------------------------------------------------------------------
            Current liabilities
 4.20       Payables                                      (1,150,825)           (912,333)        (1,071,017)
 4.21       Interest bearing liabilities                            -                   -                  -
 4.22       Tax liabilities                                         -                   -                  -
 4.23       Provisions exc. tax liabilities                         -                   -           (23,434)
 4.24       Other (provide details if material)                     -                   -                  -
                                                      -------------------------------------------------------
 4.25       Total current liabilities                     (1,150,825)           (912,333)        (1,094,451)
 ------------------------------------------------------------------------------------------------------------
            Non-current liabilities
 4.26       Payables                                                -                   -                  -
 4.27       Interest bearing liabilities                            -                   -                  -
 4.28       Tax liabilities                                         -                   -                  -
 4.29       Provisions exc. tax liabilities                         -                   -                  -
 4.30       Other (provide details if material)                     -                   -                  -
                                                      -------------------------------------------------------
 4.31       Total non-current liabilities                           -                   -                  -
                                                      -------------------------------------------------------



--------------------------------------------------------------------------------
                                                                   Page 9 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------



Condensed consolidated statement of financial position continued

 ------------------------------------------------------------------------------------------------------------
                                                                                     
 4.32       Total liabilities                             (1,150,825)           (912,333)        (1,094,451)
 ------------------------------------------------------------------------------------------------------------
 4.33       Net assets                                     13,733,209          16,668,986         18,858,955
 ------------------------------------------------------------------------------------------------------------
                                                      -------------------------------------------------------
           Equity
 4.34      Capital/contributed equity                      13,203,806          13,001,468         12,276,893
 4.35      Reserves                                        14,661,942          14,661,942         14,661,942
 4.36      Retained profits (accumulated losses)         (14,132,539)        (10,994,424)        (8,079,880)
 ------------------------------------------------------------------------------------------------------------
 4.37      Equity attributable to members of the
           parent entity                                   13,733,209          16,668,986         18,858,955
 4.38      Outside +equity interests in controlled                  -                   -                  -
           entities
                                                      -------------------------------------------------------
 4.39      Total equity                                    13,733,209          16,668,986         18,858,955
 ------------------------------------------------------------------------------------------------------------
                                                      -------------------------------------------------------
 4.40      Preference  capital  included  as part of                -                   -                  -
           4.37
 ------------------------------------------------------------------------------------------------------------


Notes to the condensed consolidated statement of financial position



Exploration and evaluation expenditure capitalised
(To be completed only by entities with mining interests if amounts are material.
Include all expenditure incurred.)

                                                              -----------------------------------------
                                                              Current period             Previous
                                                                    $A             corresponding period
                                                                                      July - Dec 01
                                                                                            $A
                                                              -----------------------------------------
                                                                                    
5.1      Opening balance                                             -                       -
5.2      Expenditure incurred during current period                  -                       -
5.3      Expenditure written off during current period               -                       -
5.4      Acquisitions, disposals, revaluation increments,            -                       -
         etc.
5.5      Expenditure transferred to Development Properties           -                       -
                                                              -----------------------------------------
5.6      Closing balance as shown in the consolidated                -                       -
         balance sheet (item 4.12)
-------------------------------------------------------------------------------------------------------



Development properties
(To be completed only by entities with mining interests if amounts are material)

                                                               ----------------------------------------------
                                                                   Current period             Previous
                                                                         $A             corresponding period
                                                                                           July - Dec 01
                                                                                                 $A
                                                               ----------------------------------------------
                                                                                        
6.1      Opening balance                                                 -                       -
6.2      Expenditure incurred during current period                      -                       -
6.3      Expenditure transferred from exploration and                    -                       -
         evaluation
6.4      Expenditure written off during current period                   -                       -
6.5      Acquisitions, disposals, revaluation increments,                -                       -
         etc.
6.6      Expenditure transferred to mine properties                      -                       -

                                                               ----------------------------------------------
6.7      Closing balance as shown in the consolidated                    -                       -
         balance sheet (item 4.13)
                                                               ----------------------------------------------

--------------------------------------------------------------------------------
                                                                   Page 10 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------



Condensed consolidated statement of cash flows

                                                         ------------------------------------------------
                                                             Current period              Previous
                                                                   $A              corresponding period
                                                                                      July - Dec 01
                                                                                            $A
                                                         ------------------------------------------------
                                                                                     
       Cash flows related to operating activities
 7.1   Receipts from customers                                                 -                       -
 7.2   Payments to suppliers and employees                            (2,725,319)             (2,134,117)
 7.3   Dividends received from associates                                      -                       -
 7.4   Other dividends received                                                -                       -
 7.5   Interest and other items of similar nature
       received                                                           57,483                 163,634
 7.6   Interest and other costs of finance paid                                -                       -
 7.7   Income taxes paid                                                       -                       -
 7.8   Other - Start Grant                                               467,945                 695,000
                                                         ------------------------------------------------
 7.9   Net operating cash flows                                       (2,199,891)             (1,275,483)
 --------------------------------------------------------------------------------------------------------

       Cash flows related to investing activities
 7.10  Payment for purchases of property, plant and
       equipment                                                         (87,812)                (71,285)
 7.11  Proceeds from sale of property, plant and
       equipment                                                               -                       -
 7.12  Payment for purchases of equity investments                             -                       -
 7.13  Proceeds from sale of equity investments                                -                       -
 7.14  Loans to other entities                                                 -                       -
 7.15  Loans repaid by other entities                                          -                       -
 7.16  Other (provide details if material)                                     -                       -
                                                         ------------------------------------------------
 7.17  Net investing cash flows                                          (87,812)                (71,285)
 --------------------------------------------------------------------------------------------------------

       Cash flows related to financing activities
 7.18  Proceeds from issues of +securities (shares,
       options, etc.)                                                    148,714                       -
 7.19  Proceeds from borrowings                                                -                       -
 7.20  Repayment of borrowings                                                 -                       -
 7.21  Dividends paid                                                          -                       -
 7.22  Other (provide details if material)                                     -                       -
                                                         ------------------------------------------------
 7.23  Net financing cash flows                                          148,714                       -
 --------------------------------------------------------------------------------------------------------
 7.24  Net increase (decrease) in cash held                           (2,138,989)             (1,346,768)
 7.25  Cash at beginning of period                                     3,585,014               6,854,873
       (see Reconciliation of cash)
 7.26  Exchange rate adjustments to item 7.25.                                 -                       -
                                                         ------------------------------------------------
 7.27  Cash at end of period                                           1,446,025               5,508,105
       (see Reconciliation of cash)
                                                         ------------------------------------------------


Non-cash financing and investing activities

Details of financing and investing transactions which have had a material effect
on consolidated assets and liabilities but did not involve cash flows are as
follows. ( If an amount is quantified, show comparative amount.)
     ----------------------------------------------------------------------

     ----------------------------------------------------------------------

--------------------------------------------------------------------------------
                                                                   Page 11 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------




Reconciliation of cash
                                                               -----------------------------------------------
 Reconciliation of cash at the end of the period (as shown         Current period             Previous
 in the consolidated statement of cash flows) to the related             $A             corresponding period
 items in the accounts is as follows.                                                      July - Dec 01
                                                                                                 $A
 -------------------------------------------------------------------------------------------------------------
                                                                                      
 8.1     Cash on hand and at bank                                      1,446,025               5,508,105
 8.2     Deposits at call                                                      -                       -
 8.3     Bank overdraft                                                        -                       -
 8.4     Other (provide details)                                               -                       -
                                                               ------------------------------------------
 8.5     Total cash at end of period (item 7.27)                       1,446,025               5,508,105
 --------------------------------------------------------------------------------------------------------



Other notes to the condensed financial statements

                                                               ---------------------------------------------
Ratios                                                             Current period             Previous
                                                                         $A             corresponding period
                                                                                           July - Dec 01
                                                                                                 $A
                                                               ---------------------------------------------
                                                                                      
         Profit before tax / revenue
9.1      Consolidated profit (loss) from ordinary activities           (595.81%)               (421.55%)
         before tax (item 1.5) as a percentage of revenue
         (item 1.1)
---------------------------------------------------------------------------------------------------------
         Profit after tax / +equity interests
9.2      Consolidated net profit (loss) from ordinary                   (22.85%)                (13.44%)
         activities after tax attributable to members (item
         1.11) as a percentage of equity (similarly
         attributable) at the end of the period (item 4.37)
------------------------------------------------------------------------------------------------------------


--------------------------------------------------------------------------------
                                                                   Page 12 of 26




                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


Earnings per security (EPS)

10.  Details of basic and diluted EPS reported  separately  in  accordance  with
     paragraph 9 and 18 of AASB 1027: Earnings Per Share are as follows.
--------------------------------------------------------------------------------

Basic Earnings per share   (5.34 cents)
------------------------
(Item 1.18)

Net Loss for period (Item 1.1)                3,138,115
Weighted Average Number of ordinary Shares = 58,721,755

Diluted Earnings per share
--------------------------

Diluted Earnings per Share is the same as Basic earnings per share as the
dilutive options have not increased the loss per share.

--------------------------------------------------------------------------------

                                         ---------------------------------------
 NTA backing                             Current period  Previous corresponding
 (see note 7)                                  $A                period
                                                             July - Dec 01
                                                                   $A
 -------------------------------------------------------------------------------

 11.1   Net tangible asset backing
        per +ordinary security              $0.010                $0.0810
                                         ---------------------------------------

Discontinuing Operations
(Entities must report a description of any significant activities or events
relating to discontinuing operations in accordance with paragraph 7.5 (g) of
AASB 1029: Interim Financial Reporting, or, the details of discontinuing
operations they have disclosed in their accounts in accordance with AASB 1042:
Discontinuing Operations (see note 17).)

12.1     Discontinuing Operations
--------------------------------------------------------------------------------
Not applicable
--------------------------------------------------------------------------------

Control gained over entities having material effect

                                             -----------------------------------
   13.1  Name of entity (or group of         Not applicable
         entities)
                                             -----------------------------------

                                                                   -------------

   13.2 Consolidated profit (loss) from ordinary activities and
        extraordinary  items after tax of the controlled entity
        (or group of entities)  since the date in  the current     $
        period on which control was +acquired
                                                                   -------------
   13.3 Date from which such profit has been calculated
                                                                   -------------
   13.4 Profit    (loss)   from   ordinary    activities    and
        extraordinary  items after tax of the controlled entity
        (or group of entities)  for the whole of the previous      $
        corresponding period
                                                                   -------------

--------------------------------------------------------------------------------
                                                                   Page 13 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------

Loss of control of entities having material effect

                                                   -----------------------------
   14.1     Name of entity (or group of entities)  Not applicable
                                                   -----------------------------

                                                                       ---------
   14.2 Consolidated profit (loss) from ordinary activities and
        extraordinary  items after tax of the controlled entity
        (or group of entities)  for the current  period to the          $
        date of loss of control
                                                                       ---------
   14.3 Date to which the  profit  (loss) in item 14.2 has been
        calculated
                                                                       ---------
   14.4 Consolidated profit (loss) from ordinary activities and
        extraordinary  items after tax of the controlled entity
        (or group of  entities)  while  controlled  during the         $
        whole of the previous corresponding period
                                                                       ---------
   14.5 Contribution   to   consolidated   profit  (loss)  from
        ordinary  activities and extraordinary  items from sale
        of interest leading to loss of control                         $
                                                                       ---------

Dividends (in the case of a trust, distributions)

                                                                  --------------
   15.1 Date the dividend (distribution) is payable               Not applicable
                                                                  --------------
                                                                  --------------
   15.2 +Record date to determine  entitlements to the dividend
        (distribution)  (ie, on the basis of proper instruments
        of transfer  received by 5.00 pm if +securities are not
        +CHESS   approved,   or   security   holding   balances
        established  by 5.00 pm or such later time permitted by
        SCH Business Rules if +securities are +CHESS approved)
                                                                  --------------
                                                                  --------------
   15.3 If  it is a  final  dividend,  has  it  been  declared?
        (Preliminary final report only)
                                                                  --------------



Amount per security

----------------------------------------------------------------------------------------------------------------
                                                               Amount per     Franked amount      Amount per
                                                                security       per security      security of
                                                                                 at % tax       foreign source
                                                                               (see note 4)        dividend
----------------------------------------------------------------------------------------------------------------
                                                                                          
            (Preliminary final report only)

15.4        Final dividend:      Current year                      -(cent)         -(cent)            -(cent)

15.5                             Previous year                     -(cent)         -(cent)            -(cent)
----------------------------------------------------------------------------------------------------------------
            (Half yearly and preliminary final reports)

15.6        Interim dividend:    Current year                      -(cent)          -(cent)           -(cent)

15.7                             Previous year                     -(cent)          -(cent)           -(cent)
----------------------------------------------------------------------------------------------------------------


--------------------------------------------------------------------------------
                                                                   Page 14 of 26

                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------

Total dividend (distribution) per security (interim plus final)
(Preliminary final report only)
                                         ----------------------------
                                         Current year   Previous year
                                         ----------------------------
15.8     +Ordinary securities              n/a             n/a
15.9     Preference +securities            n/a             n/a
                                         ----------------------------

Half yearly report - interim dividend (distribution) on all securities or
Preliminary final report - final dividend (distribution) on all securities

                                                  ------------------------------
                                                  Current period    Previous
                                                        $A        corresponding
                                                                     period
                                                                   July - Dec 01
                                                                       $A
                                                  ------------------------------
15.10      +Ordinary securities
           (each class separately)                       -               -
15.11      Preference +securities (each class            -               -
           separately)
15.12      Other equity instruments (each class          -               -
           separately)
                                                  ------------------------------
                                                         -               -
15.13      Total
                                                  ------------------------------

The +dividend or distribution plans shown below are in operation.
--------------------------------------------------------------------------------


--------------------------------------------------------------------------------
                                                                 ---------------
The last date(s) for receipt of election notices for the
+dividend or distribution plans
                                                                 ---------------

Any other disclosures in relation to dividends (distributions). (For half yearly
reports,  provide  details  in  accordance  with  paragraph  7.5(d) of AASB 1029
Interim Financial Reporting)

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------


Details of aggregate share of profits (losses) of associates and joint venture entities
                                                             ------------------------------
                                                             Current period      Previous
 Group's share of associates' and joint                           $A          corresponding
  venture entities':                                                              period
                                                                              July - Dec 01
                                                                                   $A
                                                             ------------------------------
                                                                          
 16.1    Profit (loss) from ordinary activities before tax        -                -
 16.2    Income tax on ordinary activities                        -                -
                                                             ------------------------------
 16.3    Profit (loss) from ordinary activities after tax         -                -
 16.4    Extraordinary items net of tax                           -                -
                                                             ------------------------------
 16.5    Net profit (loss)                                        -                -
 16.6    Adjustments                                              -                -
                                                             ------------------------------
 16.7    Share of net profit (loss) of associates and             -                -
         joint venture entities
                                                             ------------------------------

--------------------------------------------------------------------------------
                                                                   Page 15 of 26

                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


Material interests in entities which are not controlled entities

The economic entity has an interest (that is material to it) in the following
entities. (If the interest was acquired or disposed of during either the current
or previous corresponding period, indicate date of acquisition ("from dd/mm/yy")
or disposal ("to dd/mm/yy").)



                               ------------------------------------------------------------------------------
 Name of entity                  Percentage of ownership interest        Contribution to net profit (loss)
                                 held at end of period or date of                   (item 1.9)
                                             disposal
-------------------------------------------------------------------------------------------------------------
                                    Current            Previous         Current period          Previous
                                     Period          corresponding            $A             corresponding
                                                        period                                   period
                                                                                             July - Dec 01
                                                                                                   $A
                               ------------------------------------------------------------------------------
                                                                                     
 17.1   Equity accounted              n/a                 0%                  n/a                   0
        associates and joint
        venture entities
 ------------------------------------------------------------------------------------------------------------
 17.2   Total                         n/a                 0%                  n/a                   0
 ------------------------------------------------------------------------------------------------------------
 17.3   Other material                n/a                 0%                  n/a                   0
        interests
 ------------------------------------------------------------------------------------------------------------
 17.4   Total                         n/a                 0%                  n/a                   0
 ------------------------------------------------------------------------------------------------------------



--------------------------------------------------------------------------------
                                                                   Page 16 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------



Issued and quoted securities at end of current period
(Description must include rate of interest and any redemption or conversion
rights together with prices and dates)

                                            ------------------------------------------------------------------
                                                                                 Issue price     Amount paid
Category of +securities                       Total number      Number quoted    per security      up per
                                                                                (see note 14)     security
                                                                                  (cents)         (see
                                                                                                   note
                                                                                                   14)
                                                                                                   (cents)
                                            ------------------------------------------------------------------
                                                                                    
18.1       Preference +securities                           -                -
           (description)

                                            ------------------------------------------------------------------
18.2       Changes during current period
           (a)  Increases through issues
           (b)  Decreases through returns
           of capital, buybacks,
           redemptions
--------------------------------------------------------------------------------------------------------------
18.3       +Ordinary securities                    58,939,045       58,939,045

                                            ------------------------------------------------------------------
18.4       Changes during current period
           (a)  Increases through issues              326,295          326,295
           (b)  Decreases through returns                   -
           of capital, buybacks
--------------------------------------------------------------------------------------------------------------
18.5       +Convertible debt securities                     -
           (description and conversion
           factor)

                                            ------------------------------------------------------------------
18.6       Changes during current period
           (a) Increases through issues
           (b) Decreases through securities
           matured, converted
--------------------------------------------------------------------------------------------------------------
18.7       Options  (description and                                               Exercise        Expiry
           conversion factor)                                                       price           date
                                                                                                  (if any)
                                                                                ------------------------------
           PBTO                                     7,000,157        7,000,157         $0.50       01/03/03
           PBTAK                                   20,200,000                -         $0.50       01/12/04
           PBTAM                                      200,000                -         $0.50       01/03/04
           PBTAO                                      410,000                -         $0.50       30/06/05
           PBTAQ                                      200,000                -         $0.50       01/10/05
                                            ------------------------------------------------------------------
                                                   28,010,157        7,000,157
                                            ------------------------------------------------------------------
18.8       Issued during current period               413,274
                                            ------------------------------------------------------------------
18.9       Exercised during current period            297,427
                                            ------------------------------------------------------------------
18.10      Expired during current period                    -                -
--------------------------------------------------------------------------------------------------------------
                                                            -
18.11      Debentures  (description)

18.12      Changes during current period
           (a)  Increases through issues

           (b) Decreases through securities
               matured, converted
--------------------------------------------------------------------------------


--------------------------------------------------------------------------------
                                                                   Page 17 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


-------------------------------------------------------------------------------

18.13      Unsecured notes  (description)                  -


           Changes during current period
18.14
           (a) Increases through issues

           (b) Decreases through securities matured, converted
-------------------------------------------------------------------------------


Segment reporting
(Information  on the  business and  geographical  segments of the entity must be
reported for the current period in accordance with AASB 1005:  Segment Reporting
and for half year  reports,  AASB 1029:  Interim  Financial  Reporting.  Because
entities  employ  different  structures a pro forma cannot be provided.  Segment
information in the layout employed in the entity's  +accounts should be reported
separately and attached to this report.)

The Company's  activities are predominantly  within Australia and cover research
into Alzheimer's Disease and other major age-related degenerative disorders.

Comments by directors
(Comments  on the  following  matters are required by ASX or, in relation to the
half yearly report, by AASB 1029: Interim Financial  Reporting.  The comments do
not take the place of the  directors'  report and  statement (as required by the
Corporations  Act)  and may be  incorporated  into  the  directors'  report  and
statement.  For both half yearly and preliminary final reports,  if there are no
comments  in a section,  state NIL. If there is  insufficient  space to comment,
attach notes to this report.)

Basis of financial report preparation

19.1 If this report is a half yearly report,  it is a general purpose  financial
     report prepared in accordance with the listing rules and AASB 1029: Interim
     Financial Reporting. It should be read in conjunction with the last +annual
     report and any  announcements  to the market made by the entity  during the
     period.  The financial  statements in this report are "condensed  financial
     statements"  as defined in AASB 1029:  Interim  Financial  Reporting.  This
     report does not include all the notes of the type  normally  included in an
     annual financial report. [Delete if preliminary final report.]

19.2 Material factors affecting the revenues and expenses of the economic entity
     for the  current  period.  In a half  yearly  report,  provide  explanatory
     comments about any seasonal or irregular factors affecting operations.

            -------------------------------------------------------------------

             Nil
            -------------------------------------------------------------------

19.3 A description  of each event since the end of the current  period which has
     had a material effect and which is not already  reported  elsewhere in this
     Appendix or in attachments, with financial effect quantified (if possible).

           --------------------------------------------------------------------

            Nil
           --------------------------------------------------------------------

19.4 Franking credits available and prospects for paying fully or partly franked
     dividends for at least the next year.


--------------------------------------------------------------------------------
                                                                   Page 18 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


 -------------------------------------------------------------------------------
 nil

 -------------------------------------------------------------------------------

19.5 Unless  disclosed below, the accounting  policies,  estimation  methods and
     measurement  bases  used in this  report  are the same as those used in the
     last annual report. Any changes in accounting policies,  estimation methods
     and  measurement  bases  since the last  annual  report  are  disclosed  as
     follows.  (Disclose  changes and  differences  in the half yearly report in
     accordance with AASB 1029: Interim Financial Reporting. Disclose changes in
     accounting policies in the preliminary final report in accordance with AASB
     1001: Accounting Policies-Disclosure).

--------------------------------------------------------------------------------
  -

--------------------------------------------------------------------------------

19.6 Revisions in estimates of amounts reported in previous interim periods. For
     half yearly  reports the nature and amount of  revisions  in  estimates  of
     amounts  reported in previous  +annual  reports if those  revisions  have a
     material effect in this half year.

--------------------------------------------------------------------------------
  -

--------------------------------------------------------------------------------

19.7 Changes in contingent liabilities or assets. For half yearly reports,
     changes in contingent liabilities and contingent assets since the last +
     annual report.

--------------------------------------------------------------------------------
There has been no change in the status of the matter of P.N. Gerolymatos since
the last annual report other than that disclosed in public announcements on the
ASX.
--------------------------------------------------------------------------------

Additional disclosure for trusts

                                                                 --------------
20.1 Number  of  units   held  by  the   management   company
     or responsible  entity or their related parties.           Not applicable
                                                                 --------------
                                                                 --------------
20.2 A  statement  of the fees  and  commissions  payable
     to them anagement company or responsible entity.

           Identify:
           -        initial service charges
           -        management fees
           -        other fees
                                                                 --------------


--------------------------------------------------------------------------------
                                                                   Page 19 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------



Annual meeting
(Preliminary final report only)

The annual meeting will be held as follows:
                                                           ---------------------
Place                                                               n/a
                                                           ---------------------
Date
                                                           ---------------------
Time
                                                           ---------------------
Approximate date the +annual report will be available
                                                           ---------------------


Compliance statement

1    This report has been prepared in accordance with AASB Standards, other AASB
     authoritative  pronouncements  and Urgent Issues Group  Consensus  Views or
     other standards acceptable to ASX (see note 12).

                                               ---------------------------------
       Identify other standards used           n/a

                                               ---------------------------------

2    This  report,  and the  +accounts  upon  which  the  report  is  based  (if
     separate), use the same accounting policies.


3    This report does give a true and fair view of the  matters  disclosed  (see
     note 2).

4    This report is based on +accounts to which one of the following applies.

      (Tick one)
       The +accounts have been audited.   X  The  +accounts  have been subject
                                             to review.

      The   +accounts   are   in   the       The  +accounts  have not yet been
      process   of  being   audited  or      audited or reviewed.
      subject to review.


5    If the audit  report or review by the auditor is not  attached,  details of
     any qualifications are attached.

6    The entity has a formally constituted audit committee.


Sign here:       /s/Geoffrey Kempler                    Date: 13 March 2003
                  Director


Print name:       Geoffrey Kempler


--------------------------------------------------------------------------------
                                                                   Page 20 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


Notes

1.   For  announcement to the market The percentage  changes referred to in this
     section are the  percentage  changes  calculated  by comparing  the current
     period's figures with those for the previous  corresponding  period. Do not
     show  percentage  changes if the  change is from  profit to loss or loss to
     profit,  but still show  whether  the change was up or down.  If changes in
     accounting  policies or procedures  have had a material  effect on reported
     figures,  do not show either  directional or percentage changes in profits.
     Explain  the  reason  for  the  omissions  in the  note  at the  end of the
     announcement  section.  Entities are  encouraged  to attach notes or fuller
     explanations of any significant  changes to any of the items in page 1. The
     area at the end of the announcement  section can be used to provide a cross
     reference to any such attachment.

2.   True and fair view If this  report  does not give a true and fair view of a
     matter (for example,  because  compliance  with an  Accounting  Standard is
     required) the entity must attach a note  providing  additional  information
     and explanations to give a true and fair view.

3.   Condensed consolidated statement of financial performance

     Item 1.1  The  definition  of  "revenue"  and an  explanation  of "ordinary
               activities"  are set out in AASB  1004:  Revenue,  and AASB 1018:
               Statement of Financial Performance.

     Item 1.6  This item  refers to the total  tax  attributable  to the  amount
               shown in item 1.5. Tax includes  income tax and capital gains tax
               (if any) but excludes  taxes  treated as expenses  from  ordinary
               activities (eg, fringe benefits tax).

4.   Income tax If the amount provided for income tax in this report differs (or
     would differ but for  compensatory  items) by more than 15% from the amount
     of income tax prima facie payable on the profit before tax, the entity must
     explain in a note the major items  responsible for the difference and their
     amounts.  The rate of tax  applicable  to the franking  amount per dividend
     should be  inserted  in the  heading  for the  column  "Franked  amount per
     security at % tax" for items 15.4 to 15.7.

5.   Condensed consolidated statement of financial position

     Format The  format of the  consolidated  statement  of  financial  position
     should be followed as closely as possible. However, additional items may be
     added if greater  clarity of  exposition  will be  achieved,  provided  the
     disclosure  still meets the  requirements of AASB 1029:  Interim  Financial
     Reporting,  and AASB 1040:  Statement of Financial Position.  Also, banking
     institutions,  trusts and  financial  institutions  may  substitute a clear
     liquidity ranking for the Current/Non-Current classification.

     Basis  of  revaluation  If  there  has  been  a  material   revaluation  of
     non-current  assets (including  investments) since the last +annual report,
     the entity must describe the basis of revaluation  adopted. The description
     must meet the requirements of AASB 1010:  Accounting for the Revaluation of
     Non-Current  Assets.  If the  entity  has  adopted a  procedure  of regular
     revaluation, the basis for which has been disclosed and has not changed, no
     additional disclosure is required.

6.   Condensed  consolidated  statement of cash flows For  definitions of "cash"
     and other terms used in this report see AASB 1026: Statement of Cash Flows.
     Entities should follow the form as closely as possible,  but variations are
     permitted if the directors (in the case of a trust, the management company)
     believe that this presentation is inappropriate.  However, the presentation
     adopted  must  meet the  requirements  of AASB  1026.  +Mining  exploration
     entities may use the form of cash flow statement in Appendix 5B.

--------------------------------------------------------------------------------
                                                                   Page 21 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


7.   Net tangible asset backing Net tangible  assets are determined by deducting
     from total tangible  assets all claims on those assets ranking ahead of the
     +ordinary  securities  (ie, all  liabilities,  preference  shares,  outside
     +equity  interests etc).  +Mining  entities are not required to state a net
     tangible asset backing per +ordinary security.

8.   Gain and loss of control  over  entities The gain or loss must be disclosed
     if it has a material  effect on the  +accounts.  Details  must  include the
     contribution for each gain or loss that increased or decreased the entity's
     consolidated profit (loss) from ordinary activities and extraordinary items
     after tax by more than 5% compared to the previous corresponding period.

9.   Rounding of figures This report  anticipates that the information  required
     is given to the nearest $1,000. If an entity reports exact figures,  the $A
     headings  must be amended.  If an entity  qualifies  under ASIC Class Order
     98/0100 dated 10 July 1998, it may report to the nearest  million  dollars,
     or to the nearest $100,000, and the $A headings must be amended.

10.  Comparative  figures  Comparative figures are to be presented in accordance
     with AASB 1018 or AASB 1029 Interim Financial  Reporting as appropriate and
     are the  unadjusted  figures from the latest  annual or half year report as
     appropriate.  However, if an adjustment has been made in accordance with an
     accounting standard or other reason or if there is a lack of comparability,
     a note  explaining  the position  should be attached.  For the statement of
     financial  performance,  AASB 1029  Interim  Financial  Reporting  requires
     information  on a year to date basis in  addition  to the  current  interim
     period.  Normally  an  Appendix  4B to which  AASB 1029  Interim  Financial
     Reporting  applies  would  be  for  the  half  year  and  consequently  the
     information  in the current period is also the year to date. If an Appendix
     4B Half yearly  version is produced for an  additional  interim  period (eg
     because of a change of reporting period),  the entity must provide the year
     to  date  information  and  comparatives  required  by  AASB  1029  Interim
     Financial  Reporting.  This should be in the form of a multi-column version
     of the consolidated  statement of financial performance as an attachment to
     the additional Appendix 4B.

11.  Additional  information An entity may disclose additional information about
     any  matter,  and  must  do  so  if  the  information  is  material  to  an
     understanding  of the reports.  The  information may be an expansion of the
     material  contained in this report,  or contained in a note attached to the
     report.  The requirement  under the listing rules for an entity to complete
     this report does not prevent the entity  issuing  reports more  frequently.
     Additional  material lodged with the +ASIC under the  Corporations Act must
     also be given to ASX. For example, a director's report and declaration,  if
     lodged with the +ASIC, must be given to ASX.

12.  Accounting Standards ASX will accept, for example, the use of International
     Accounting  Standards for foreign  entities.  If the standards  used do not
     address a topic, the Australian standard on that topic (if one exists) must
     be complied with.

13.  Corporations Act financial statements This report may be able to be used by
     an entity  required  to  comply  with the  Corporations  Act as part of its
     half-year  financial  statements if prepared in accordance  with Australian
     Accounting Standards.

14.  Issued  and quoted  securities  The issue  price and amount  paid up is not
     required in items 18.1 and 18.3 for fully paid securities.

15   Details of expenses AASB 1018 requires disclosure of expenses from ordinary
     activities  according  to either  their  nature or  function.  For  foreign
     entities,  there are similar  requirements  in other  accounting  standards
     accepted by ASX. AASB ED 105  clarifies  that the  disclosures  required by
     AASB 1018 must be  either  all  according  to  nature or all  according  to
     function.

--------------------------------------------------------------------------------
                                                                   Page 22 of 26


                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


     Entities must disclose  details of expenses  using the layout (by nature or
     function) employed in their +accounts.

     The  information  in lines 1.23 to 1.27 may be provided in an attachment to
     Appendix 4B.

     Relevant  Items AASB 1018  requires  the  separate  disclosure  of specific
     revenues and expenses which are not  extraordinary but which are of a size,
     nature or incidence that disclosure is relevant in explaining the financial
     performance  of the reporting  entity.  The term  "relevance" is defined in
     AASB  1018.  There  is an  equivalent  requirement  in AASB  1029:  Interim
     Financial Reporting.  For foreign entities,  there are similar requirements
     in other accounting standards accepted by ASX.

16   Dollars If reporting is not in A$, all  references to $A must be changed to
     the reporting  currency.  If reporting is not in thousands of dollars,  all
     references to "000" must be changed to the reporting value.

17.  Discontinuing operations

     Half yearly report

     All entities must provide the information required in paragraph 12 for half
     years beginning on or after 1 July 2001.

     Preliminary final report

     Entities must either provide a description of any significant activities or
     events relating to discontinuing  operations equivalent to that required by
     paragraph  7.5 (g) of AASB  1029:  Interim  Financial  Reporting,  or,  the
     details of discontinuing  operations they are required to disclose in their
     +accounts in accordance with AASB 1042 Discontinuing Operations.

     In any  case the  information  may be  provided  as an  attachment  to this
     Appendix 4B.

18.  Format

     This form is a Word  document but an entity can re-format the document into
     Excel or similar applications for submission to the Companies Announcements
     Office in ASX.

19.  Changes in Accounting Standards

     The following  changes have occurred in Accounting  Standards  since 1 July
     2002 and these changes have been adopted where  appropriate  in preparation
     of this report:

     -        SB 1012 - Foreign Currency Translation
     -        SB 1028 - Employee Benefits
     -        SB 1044 - Provisions, Contingent Liabilities and Contingent Assets

--------------------------------------------------------------------------------
                                                                   Page 23 of 26



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


20.  Income Tax Note

     --------------------------------------------------------------------
                                                  Dec 2002      Dec 2001
     --------------------------------------------------------------------
     Prima facie income tax on the operating       941,434       760,177
     loss before income  tax at 30%

     --------------------------------------------------------------------
     Non-Tax Deductible Items
     - Amortisation of Intangibles               (165,000)     (165,000)

     --------------------------------------------------------------------
     Timing  differences  and tax  losses not
     brought to account as future  income tax
     benefits                                      776,434       595,177

     --------------------------------------------------------------------
     Income Tax Expense                                  -             -

     --------------------------------------------------------------------


--------------------------------------------------------------------------------
                                                                   Page 24 of 26




                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------


                           PRANA BIOTECHNOLOGY LIMITED
                               ABN 37 080 699 065

                            INTERIM FINANCIAL REPORT

                             DIRECTORS' DECLARATION
                                31 December 2002


The directors of the company declare that:

     1.   The financial statements and notes, as set out on pages 5 to 24:

          a.   Comply with  Accounting  Standards AASB 1029:  Interim  Financial
               Reporting and the Corporations Regulations 2001; and

          b.   Give a true and fair view of the company's  financial position as
               at 31  December  2002 and of its  performance  for the  half-year
               ended on that date.

     2.   In the directors' opinion there are reasonable grounds to believe that
          the company  will be able to pay its debts as and when they become due
          and payable.

This  declaration  is made in  accordance  with a  resolution  of the  Board  of
Directors.




Director          /s/Geoffrey Kempler
                  Geoffrey Kempler



Dated this        13th day of March 2003

--------------------------------------------------------------------------------
                                                                   Page 25 of 25



                                                                     Appendix 4B
Prana Biotechnology Limited                Half yearly report - 31 December 2002
--------------------------------------------------------------------------------

                                 AUDITOR REPORT

Deloitte Touche Tohmatsu
A.B.N. 74 490 121 060 505 Bourke Street
Melbourne VIC 3000                                                      Deloitte
GPO Box 78B                                                               Touche
Melbourne VIC 300T Australia                                            Tohmatsu

DX 111
Telephone (03) 9208 7000
Facsimile (03) 9208 7001
www.deloitte.com.au

                    INDEPENDENT REVIEW REPORT TO THE MEMBERS
                         OF PRANA BIOTECHNOLOGY LIMITED
Scope
-----
We have reviewed the attached financial report of Prana Biotechnology Limited in
the form of Appendix 4B of the Australian Stock Exchange (ASX) Listing Rules as
set out on pages 5 to 27, including the directors' declaration, for the
half-year ended 31 December 2002, but excluding the following sections:

a)       material factors affecting the revenues and expenses of the entity for
         the current period (page 16); and
b)       compliance statement (page 20).

The disclosing entity's directors are responsible for the financial report. We
have performed an independent review of the financial report in order to state
whether, on the basis of the procedures described, anything has come to our
attention that would indicate that the financial report is not presented fairly
in accordance with Accounting Standard AASB 1029 "Interim Financial Reporting"
and other mandatory professional reporting requirements in Australia, statutory
requirements and ASX Listing Rules as they relate to Appendix 4B, so as to
present a view which is consistent with our understanding of the disclosing
entity's financial position, and performance as represented by the results of
its operations and its cash flows, and in order for the disclosing entity to
meet its obligations to lodge the financial report with the Australian
Securities and Investments Commission and the ASX.

Our review has been conducted in acordance with Australian Auditing Standards
applicable to review engagements. A review is limited primarily to inquiries of
the entity's personnel and analytical procedures applied to the financial data.
These procedures do not provide all the evidence that would be required in an
audit, thus the level of assurance provided is less than given in an audit. We
have not performed an audit and, accordingly, we do not express an audit
opinion.

Statement
---------
Based on our review, which is not an audit, we have not become aware of any
matter that makes us believe that the half-year financial report of Prana
Biotechnology Limited is not in accordance with:

(a) the Corporations Act 2001, including:

     (i)  giving a true  and  fair  view of the  disclosing  entity's  financial
          position  as at 31  December  2002  and of  its  performance  for  the
          half-year ended on that date; and

     (ii) complying  with  Accounting  Standard  AASB  1029  "Interim  Financial
          Reporting" and the Corporations Regulations 2001; and

(b)      other mandatory professional reporting requirements in Australia and
         ASX Listing Rules as they relate to Appendix 4B.

/s/Deloitte Touche Tohmatsu
Deloitte Touche Tohmatsu

/s/C J Biermann
C J Biermann
Partner
Chartered Accountants

Melbourne,      13 March 2003

                    ------------------------------------------------------------
                    The liability of Deloitte Touche Tohmatsu is limited by, and
                    to  the  extent  of,  the  Accountants'   Scheme  under  the
                    Professional Standards Act 1994 (NSW).

--------------------------------------------------------------------------------
                                                                   Page 26 of 26

                                                                          ITEM 2






                                                                     Appendix 3B
                                                          New issue announcement
--------------------------------------------------------------------------------
                                                Rule 2.7, 3.10.3, 3.10.4, 3.10.5

                                   Appendix 3B

                             New issue announcement,
               application for quotation of additional securities
                                  and agreement

Information or documents not available now must be given to ASX as soon as
available. Information and documents given to ASX become ASX's property and may
be made public.

Introduced 1/7/96. Origin: Appendix 5. Amended 1/7/98, 1/9/99, 1/7/2000,
30/9/2001, 11/3/2002, 1/1/2003.


Name of entity
-------------------------------------------------------------------------------
PRANA BIOTECHNOLOGY LIMITED
-------------------------------------------------------------------------------

ABN
----------------------------
37 080 699 065
----------------------------

We (the entity) give ASX the following information.


Part 1 - All issues
You must complete the relevant sections (attach sheets if there is not enough
space).

1 +Class of +securities issued or to be         -------------------------------
   issued                                       Ordinary Shares
                                                -------------------------------

2 Number of +securities issued or to            --------------------------------
  be issued (if known) or maximum                 3,132,391
  number which may be issued                    --------------------------------

3 Principal terms of the +securities (eg,       -------------------------------
  if options, exercise price and expiry         Pari passu with existing quoted
  date; if partly paid +securities, the         ordinary shares
  amount outstanding and due dates for          --------------------------------
  payment; if +convertible securities,
  the conversion price and dates for
  conversion)

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 1






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------

4 Do the +securities rank equally in all        -------------------------------
 respects from the date of allotment            Yes
 with an existing +class of quoted              -------------------------------
 +securities?

If the additional securities do not
rank equally, please state:
- the date from which they do
- the extent to which they
  participate for the next dividend,
  (in the case of a trust,
  distribution) or interest payment
- the extent to which
  they do not rank equally, other than in relation
  to the next dividend,
  distribution or interest payment

5 Issue price or consideration                  -------------------------------
                                                $0.50 per share
                                                -------------------------------


6 Purpose of the issue                          -------------------------------
  (If issued as consideration for the           Exercise of Options
  acquisition of assets, clearly identify
  those assets)                                  To be used for Working Capital
                                                 Purposes





                                                -------------------------------

7 Dates of entering +securities into            -------------------------------
  uncertificated holdings or                    15/3/03
  despatch of certificates                      -------------------------------



                                            --------------- ---------------
8 Number and +class of all +securities      Number          +Class
  quoted on ASX (including the              --------------- ----------------
  securities in clause 2 if applicable)     65,765,989(PBT)  Ordinary Shares
                                               336,314(PBTN) Options exercisable
                                                             at $0.50 on or
                                                             before 1 March 2003
                                            --------------- --------------------

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

Appendix 3B Page 2                                                     1/1/2003






                                                                     Appendix 3B
                                                          New issue announcement
--------------------------------------------------------------------------------



                                        ----------------------------- -------------------------
                                        Number                        +Class
                                        ----------------------------- -------------------------
                                                                 

9 Number and +class of all +securities  20,125,000 (PBTAK)            Options exercisable
  not quoted on ASX (including the                                     at $0.50 on or
  securities in clause 2 if applicable)                                before 1 December
                                                                       2004.
                                        200,000 (PBTAM)               Options exercisable
                                                                       at $0.50 on or before
                                                                       20 March 2004.
                                                                      Employee &
                                        410,000 (PBTAO)                Consultants Options
                                                                       exercisable at $0.50
                                                                       on or before 30 June
                                                                       2005.
                                        200,000 (PBTAQ)               Options exercisable
                                                                       at $0.50 on or
                                                                       before 1 October
                                                                       2005.
                                        ----------------------------- --------------------------


10 Dividend policy (in the case of a            -------------------------------
   trust, distribution policy) on the           Unchanged
   increased capital (interests)                -------------------------------

Part 2 - Bonus issue or pro rata issue

11 Is security holder approval                  -------------------------------
   required?
                                                -------------------------------

12 Is the issue renounceable or non-            -------------------------------
   renounceable?
                                                -------------------------------

13 Ratio in which the +securities will be       -------------------------------
  offered
                                                -------------------------------

14 +Class of +securities to which the           -------------------------------
   offer relates
                                                -------------------------------

15 +Record date to determine                    -------------------------------
   entitlements

16 Will holdings on different registers         -------------------------------
   (or subregisters) be aggregated for
   calculating entitlements?
                                                -------------------------------

17 Policy for deciding entitlements in          -------------------------------
   relation to fractions
                                                -------------------------------

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 3






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------


18 Names of countries in which the              -------------------------------
   entity has +security holders who will
   not be sent new issue documents

   Note: Security holders must be told how their
   entitlements are to be dealt with.

   Cross reference: rule 7.7.                   -------------------------------

19 Closing date for receipt of                  -------------------------------
   acceptances or renunciations
                                                -------------------------------

20 Names of any underwriters                    -------------------------------

                                                -------------------------------

21 Amount of any underwriting fee or            -------------------------------
   commission
                                                -------------------------------

22 Names of any brokers to the issue            -------------------------------

23 Fee or commission payable to the             -------------------------------
   broker to the issue
                                                -------------------------------

24 Amount of any handling fee                    ------------------------------
   payable to brokers who lodge
   acceptances or renunciations on
   behalf of +security holders                   -------------------------------

25 If the issue is contingent on                 -------------------------------
   +security holders' approval, the date
   of the meeting                                -------------------------------

26 Date entitlement and acceptance               -------------------------------
   form and prospectus or Product
   Disclosure Statement will be sent to
   persons entitled                              -------------------------------


27 If the entity has issued options,             -------------------------------
   and the terms entitle option holders to
   participate on exercise, the date on
   which notices will be sent to option
   holders                                       -------------------------------

28 Date rights trading will begin (if            -------------------------------
   applicable)
                                                 -------------------------------

29 Date rights trading will end (if              -------------------------------
   applicable)
                                                 -------------------------------

30 How do +security holders sell their           -------------------------------
   entitlements in full through a broker?
                                                 ------------------------------

--------------------------------------------------------------------------------
+See chapter 19 for defined terms.

Appendix 3B Page 4                                                      1/1/2003



                                                                     Appendix 3B
                                                          New issue announcement
-------------------------------------------------------------------------------

31 How do +security holders sell part           --------------------------------
   of their entitlements through a broker
   and accept for the balance?
                                                --------------------------------

32 How do +security holders dispose             --------------------------------
   of their entitlements (except by sale
   through a broker)?                           --------------------------------

33 +Despatch date                               --------------------------------

                                                --------------------------------

Part 3 - Quotation of securities
You need only complete this section if you are applying for quotation of
securities

34 Type of securities
(tick one)

(a) [X} Securities described in Part 1

(b) [ ] All other securities

                  Example: restricted securities at the end of the escrowed
                  period, partly paid securities that become fully paid,
                  employee incentive share securities when restriction ends,
                  securities issued on expiry or conversion of convertible
                  securities

Entities that have ticked box 34(a)

Additional securities forming a new class of securities

Tick to indicate you are providing the information or
documents

35      [ ]       If the +securities are +equity securities, the names of the 20
                  largest holders of the additional +securities, and the number
                  and percentage of additional +securities held by those holders

36      [ ]       If the +securities are +equity securities, a distribution
                  schedule of the additional +securities setting out the number
                  of holders in the categories

                  1 - 1,000
                  1,001 - 5,000
                  5,001 - 10,000
                  10,001 - 100,000
                  100,001 and over

37      [ ]       A copy of any trust deed for the additional +securities

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 5






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------

Entities that have ticked box 34(b)

38 Number of securities for which                 ------------------------------
   +quotation is sought
                                                  ------------------------------

39 Class of +securities for which                 ------------------------------
   quotation is sought
                                                  ------------------------------

40 Do the +securities rank equally                ------------------------------
   in all respects from the date of
   allotment with an existing +class of
   quoted +securities?                            ------------------------------

   If the additional securities do not            ------------------------------
   rank equally, please state:
   - the date from which they do
   - the extent to which they participate
     for the next dividend, (in
     the case of a trust, distribution)
     or interest payment
   - the extent to which
     they do not rank equally, other than
     in relation to the next dividend,
     distribution or interest payment
                                                  ------------------------------

41 Reason for request for quotation               ------------------------------
   now


Example: In the case of restricted securities,
end of restriction period

(if issued upon conversion of
another security, clearly identify that
other security)                                   ------------------------------

                                                  ----------------- ------------
                                                  Number            +Class
                                                  ----------------- ------------
42 Number and +class of all
   +securities quoted on ASX
   (including the
   securities in clause 38)
                                                  ----------------- ------------



--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

Appendix 3B Page 6                                                      1/1/2003






                                                                     Appendix 3B
                                                          New issue announcement
--------------------------------------------------------------------------------


Quotation agreement

1    +Quotation of our additional  +securities is in ASX's absolute  discretion.
     ASX may quote the +securities on any conditions it decides.

2    We warrant the following to ASX.

     -    The issue of the +securities to be quoted complies with the law and is
          not for an illegal purpose.

     -    There  is no  reason  why  those  +securities  should  not be  granted
          +quotation.

     -    An offer of the  +securities  for sale  within 12 months  after  their
          issue will not  require  disclosure  under  section  707(3) or section
          1012C(6) of the Corporations Act.

          Note: An entity  may  need  to  obtain  appropriate   warranties  from
          subscribers  for the  securities  in  order  to be  able to give  this
          warranty

     -    Section 724 or section 1016E of the Corporations Act does not apply to
          any  applications  received by us in relation to any +securities to be
          quoted and that no-one has any right to return any  +securities  to be
          quoted under sections 737, 738 or 1016F of the Corporations Act at the
          time that we request that the +securities be quoted.

     -    We warrant that if confirmation is required under section 1017F of the
          Corporations  Act in relation to the +securities to be quoted,  it has
          been  provided  at the time that we request  that the  +securities  be
          quoted.

     -    If we are a trust,  we warrant  that no person has the right to return
          the  +securities to be quoted under section 1019B of the  Corporations
          Act at the time that we request that the +securities be quoted.

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 7






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------


3    We will indemnify ASX to the fullest extent  permitted by law in respect of
     any claim,  action or expense  arising from or connected with any breach of
     the warranties in this agreement.

4    We give ASX the  information  and  documents  required by this form. If any
     information  or  document  not  available  now,  will give it to ASX before
     +quotation of the +securities begins. We acknowledge that ASX is relying on
     the information and documents.  We warrant that they are (will be) true and
     complete.

Sign here: /s/Richard Revelins                               Date: 13 March 2003
                  (Director/Company secretary)

Print name: RICHARD REVELINS
                                    == == == == ==
 -------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

Appendix 3B Page 8                                                      1/1/2003





                                   SIGNATURES


     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, thereunto duly authorized.


                                            PRANA BIOTECHNOLOGY LIMITED
                                            ---------------------------
                                                   (Registrant)



                                            By:  /s/Phillip Hains
                                                -------------------------------
                                                Phillip Hains
                                                Administrative Officer



Date: March 18, 2003