SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                   F O R M 6-K

       REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                          For the month of February 2003

                           Prana Biotechnology Limited
                              (Name of Registrant)


      Level 1, 100 Dorcas Street, South Melbourne, Victoria 3205 Australia
                     (Address of Principal Executive Office)

     Indicate  by check mark  whether the  registrant  files or will file annual
reports under cover of Form 20-F or Form 40-F.

                             Form 20-F   [X]    Form 40-F      [ ]

     Indicate  by check mark if the  registrant  is  submitting  the Form 6-K in
paper as permitted by Regulation S-T Rule 101(b)(1):

     Indicate  by check mark if the  registrant  is  submitting  the Form 6-K in
paper as permitted by Regulation S-T Rule 101(b)(7):

     Indicate by check mark whether by furnishing the  information  contained in
this Form,  the  registrant is also thereby  furnishing  the  information to the
Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

                                        Yes   [ ]   No   [X]

     If  "Yes"  is  marked,  indicate  below  the file  number  assigned  to the
registrant in connection with Rule 12g3-2(b): 82- ___________________







                           PRANA BIOTECHNOLOGY LIMITED

6-K Items

1.   Prana  Biotechnology  Limited  new  issue  announcement,   application  for
     quotation of additional securities and agreement dated February 14, 2003.







                                                                          ITEM 1







                                                                     Appendix 3B
                                                          New issue announcement
--------------------------------------------------------------------------------
                                                Rule 2.7, 3.10.3, 3.10.4, 3.10.5

                                   Appendix 3B

                             New issue announcement,
               application for quotation of additional securities
                                  and agreement

Information or documents not available now must be given to ASX as soon as
available. Information and documents given to ASX become ASX's property and may
be made public.

Introduced 1/7/96. Origin: Appendix 5. Amended 1/7/98, 1/9/99, 1/7/2000,
30/9/2001, 11/3/2002, 1/1/2003.


Name of entity
-------------------------------------------------------------------------------
PRANA BIOTECHNOLOGY LIMITED
-------------------------------------------------------------------------------

ABN
----------------------------
37 080 699 065
----------------------------

We (the entity) give ASX the following information.


Part 1 - All issues
You must complete the relevant sections (attach sheets if there is not enough
space).

1 +Class of +securities issued or to be         -------------------------------
   issued                                       Ordinary Shares
                                                -------------------------------

2 Number of +securities issued or to            --------------------------------
  be issued (if known) or maximum                 499,403
  number which may be issued                    --------------------------------

3 Principal terms of the +securities (eg,       -------------------------------
  if options, exercise price and expiry         Pari passu with existing quoted
  date; if partly paid +securities, the         ordinary shares
  amount outstanding and due dates for          --------------------------------
  payment; if +convertible securities,
  the conversion price and dates for
  conversion)

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 1






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------

4 Do the +securities rank equally in all        -------------------------------
 respects from the date of allotment            Yes
 with an existing +class of quoted              -------------------------------
 +securities?

If the additional securities do not
rank equally, please state:
- the date from which they do
- the extent to which they
  participate for the next dividend,
  (in the case of a trust,
  distribution) or interest payment
- the extent to which
  they do not rank equally, other than in relation
  to the next dividend,
  distribution or interest payment

5 Issue price or consideration                  -------------------------------
                                                $0.50 per share
                                                -------------------------------


6 Purpose of the issue                          -------------------------------
  (If issued as consideration for the           Exercise of Options
  acquisition of assets, clearly identify
  those assets)                                  To be used for Working Capital
                                                 Purposes





                                                -------------------------------

7 Dates of entering +securities into            -------------------------------
  uncertificated holdings or                    14/2/03
  despatch of certificates                      -------------------------------



                                            --------------- ---------------
8 Number and +class of all +securities      Number          +Class
  quoted on ASX (including the              --------------- ----------------
  securities in clause 2 if applicable)     59,618,869(PBT)  Ordinary Shares
                                            6,488,434 (PBTO) Options exercisable
                                                             at $0.50 on or
                                                             before 1 March 2003
                                            --------------- --------------------

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

Appendix 3B Page 2                                                     1/1/2003






                                                                     Appendix 3B
                                                          New issue announcement
--------------------------------------------------------------------------------



                                        ----------------------------- -------------------------
                                        Number                        +Class
                                        ----------------------------- -------------------------
                                                                 

9 Number and +class of all +securities  20,150,000 (PBTAK)            Options exercisable
  not quoted on ASX (including the                                     at $0.50 on or
  securities in clause 2 if applicable)                                before 1 December
                                                                       2004.
                                        200,000 (PBTAM)               Options exercisable
                                                                       at $0.50 on or before
                                                                       20 March 2004.
                                                                      Employee &
                                        410,000 (PBTAO)                Consultants Options
                                                                       exercisable at $0.50
                                                                       on or before 30 June
                                                                       2005.
                                        200,000 (PBTAQ)               Options exercisable
                                                                       at $0.50 on or
                                                                       before 1 October
                                                                       2005.
                                        ----------------------------- --------------------------


10 Dividend policy (in the case of a            -------------------------------
   trust, distribution policy) on the           Unchanged
   increased capital (interests)                -------------------------------

Part 2 - Bonus issue or pro rata issue

11 Is security holder approval                  -------------------------------
   required?
                                                -------------------------------

12 Is the issue renounceable or non-            -------------------------------
   renounceable?
                                                -------------------------------

13 Ratio in which the +securities will be       -------------------------------
  offered
                                                -------------------------------

14 +Class of +securities to which the           -------------------------------
   offer relates
                                                -------------------------------

15 +Record date to determine                    -------------------------------
   entitlements

16 Will holdings on different registers         -------------------------------
   (or subregisters) be aggregated for
   calculating entitlements?
                                                -------------------------------

17 Policy for deciding entitlements in          -------------------------------
   relation to fractions
                                                -------------------------------

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 3






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------


18 Names of countries in which the              -------------------------------
   entity has +security holders who will
   not be sent new issue documents

   Note: Security holders must be told how their
   entitlements are to be dealt with.

   Cross reference: rule 7.7.                   -------------------------------

19 Closing date for receipt of                  -------------------------------
   acceptances or renunciations
                                                -------------------------------

20 Names of any underwriters                    -------------------------------

                                                -------------------------------

21 Amount of any underwriting fee or            -------------------------------
   commission
                                                -------------------------------

22 Names of any brokers to the issue            -------------------------------

23 Fee or commission payable to the             -------------------------------
   broker to the issue
                                                -------------------------------

24 Amount of any handling fee                    ------------------------------
   payable to brokers who lodge
   acceptances or renunciations on
   behalf of +security holders                   -------------------------------

25 If the issue is contingent on                 -------------------------------
   +security holders' approval, the date
   of the meeting                                -------------------------------

26 Date entitlement and acceptance               -------------------------------
   form and prospectus or Product
   Disclosure Statement will be sent to
   persons entitled                              -------------------------------


27 If the entity has issued options,             -------------------------------
   and the terms entitle option holders to
   participate on exercise, the date on
   which notices will be sent to option
   holders                                       -------------------------------

28 Date rights trading will begin (if            -------------------------------
   applicable)
                                                 -------------------------------

29 Date rights trading will end (if              -------------------------------
   applicable)
                                                 -------------------------------

30 How do +security holders sell their           -------------------------------
   entitlements in full through a broker?
                                                 ------------------------------

--------------------------------------------------------------------------------
+See chapter 19 for defined terms.

Appendix 3B Page 4                                                      1/1/2003



                                                                     Appendix 3B
                                                          New issue announcement
-------------------------------------------------------------------------------

31 How do +security holders sell part           --------------------------------
   of their entitlements through a broker
   and accept for the balance?
                                                --------------------------------

32 How do +security holders dispose             --------------------------------
   of their entitlements (except by sale
   through a broker)?                           --------------------------------

33 +Despatch date                               --------------------------------

                                                --------------------------------

Part 3 - Quotation of securities
You need only complete this section if you are applying for quotation of
securities

34 Type of securities
(tick one)

(a) [X} Securities described in Part 1

(b) [ ] All other securities

                  Example: restricted securities at the end of the escrowed
                  period, partly paid securities that become fully paid,
                  employee incentive share securities when restriction ends,
                  securities issued on expiry or conversion of convertible
                  securities

Entities that have ticked box 34(a)

Additional securities forming a new class of securities

Tick to indicate you are providing the information or
documents

35      [ ]       If the +securities are +equity securities, the names of the 20
                  largest holders of the additional +securities, and the number
                  and percentage of additional +securities held by those holders

36      [ ]       If the +securities are +equity securities, a distribution
                  schedule of the additional +securities setting out the number
                  of holders in the categories

                  1 - 1,000
                  1,001 - 5,000
                  5,001 - 10,000
                  10,001 - 100,000
                  100,001 and over

37      [ ]       A copy of any trust deed for the additional +securities

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 5






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------

Entities that have ticked box 34(b)

38 Number of securities for which                 ------------------------------
   +quotation is sought
                                                  ------------------------------

39 Class of +securities for which                 ------------------------------
   quotation is sought
                                                  ------------------------------

40 Do the +securities rank equally                ------------------------------
   in all respects from the date of
   allotment with an existing +class of
   quoted +securities?                            ------------------------------

   If the additional securities do not            ------------------------------
   rank equally, please state:
   - the date from which they do
   - the extent to which they participate
     for the next dividend, (in
     the case of a trust, distribution)
     or interest payment
   - the extent to which
     they do not rank equally, other than
     in relation to the next dividend,
     distribution or interest payment
                                                  ------------------------------

41 Reason for request for quotation               ------------------------------
   now


Example: In the case of restricted securities,
end of restriction period

(if issued upon conversion of
another security, clearly identify that
other security)                                   ------------------------------

                                                  ----------------- ------------
                                                  Number            +Class
                                                  ----------------- ------------
42 Number and +class of all
   +securities quoted on ASX
   (including the
   securities in clause 38)
                                                  ----------------- ------------



--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

Appendix 3B Page 6                                                      1/1/2003






                                                                     Appendix 3B
                                                          New issue announcement
--------------------------------------------------------------------------------


Quotation agreement

1    +Quotation of our additional  +securities is in ASX's absolute  discretion.
     ASX may quote the +securities on any conditions it decides.

2    We warrant the following to ASX.

     -    The issue of the +securities to be quoted complies with the law and is
          not for an illegal purpose.

     -    There  is no  reason  why  those  +securities  should  not be  granted
          +quotation.

     -    An offer of the  +securities  for sale  within 12 months  after  their
          issue will not  require  disclosure  under  section  707(3) or section
          1012C(6) of the Corporations Act.

          Note: An entity  may  need  to  obtain  appropriate   warranties  from
          subscribers  for the  securities  in  order  to be  able to give  this
          warranty

     -    Section 724 or section 1016E of the Corporations Act does not apply to
          any  applications  received by us in relation to any +securities to be
          quoted and that no-one has any right to return any  +securities  to be
          quoted under sections 737, 738 or 1016F of the Corporations Act at the
          time that we request that the +securities be quoted.

     -    We warrant that if confirmation is required under section 1017F of the
          Corporations  Act in relation to the +securities to be quoted,  it has
          been  provided  at the time that we request  that the  +securities  be
          quoted.

     -    If we are a trust,  we warrant  that no person has the right to return
          the  +securities to be quoted under section 1019B of the  Corporations
          Act at the time that we request that the +securities be quoted.

--------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

1/1/2003                                                      Appendix 3B Page 7






Appendix 3B
New issue announcement
--------------------------------------------------------------------------------


3    We will indemnify ASX to the fullest extent  permitted by law in respect of
     any claim,  action or expense  arising from or connected with any breach of
     the warranties in this agreement.

4    We give ASX the  information  and  documents  required by this form. If any
     information  or  document  not  available  now,  will give it to ASX before
     +quotation of the +securities begins. We acknowledge that ASX is relying on
     the information and documents.  We warrant that they are (will be) true and
     complete.

Sign here: /s/Richard Revelins                            Date: 14 February 2003
                  (Director/Company secretary)

Print name: RICHARD REVELINS
                                    == == == == ==
 -------------------------------------------------------------------------------
+ See chapter 19 for defined terms.

Appendix 3B Page 8                                                      1/1/2003







                                   SIGNATURES


     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, thereunto duly authorized.


                                            PRANA BIOTECHNOLOGY LIMITED
                                            ---------------------------
                                                   (Registrant)



                                            By:  /s/Phillip Hains
                                                -------------------------------
                                                Phillip Hains
                                                Administrative Officer



Date: February 20, 2003