UNITED STATES
                         SECURITIES EXCHANGE COMMISSION
                             Washington, D.C. 20549

________________________________________________________________________________


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                                (Amendment No. 3)*

                          LIGAND PHARMACEUTICALS, INC.
                          ----------------------------
                                (Name of Issuer)


                    Common Stock, $0.001 par value per share
               -------------------------------------------------
                         (Title of Class of Securities)


                                    53220K207
                                    ---------
                                 (CUSIP Number)


                                December 31, 2007
                                -----------------
             (Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                               [ ]  Rule 13d-1(b)

                               [X]  Rule 13d-1(c)

                               [ ]  Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                          Continued on following pages
                                Page 1 of 7 Pages



                                                               Page 2 of 7 Pages


.................................................................................
1.      Names of Reporting Persons.

        I.R.S. Identification Nos. of above persons (entities only).


        GLENVIEW CAPITAL MANAGEMENT, LLC

.................................................................................
2.      Check the Appropriate Box if a Member of a Group

        (a) [  ]

        (b) [  ]
.................................................................................
3.      SEC Use Only
.................................................................................
4.      Citizenship or Place of Organization

        Delaware
.................................................................................
Number of        5.   Sole Voting Power                None
Shares           ...............................................................
Beneficially     6.   Shared Voting Power              4,740,431
Owned by         ...............................................................
Each             7.   Sole Dispositive Power           None
Reporting        ...............................................................
Person With      8.   Shared Dispositive Power         4,740,431
.................................................................................
9.      Aggregate Amount Beneficially Owned by Each Reporting Person

        4,740,431
.................................................................................
10.     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

        [  ]
.................................................................................
11.     Percent of Class Represented by Amount in Row (9)

        4.97% based on 95,433,477 shares outstanding as of October 31, 2007
.................................................................................
12.     Type of Reporting Person:

        OO



                                                               Page 3 of 7 Pages

.................................................................................
1.      Names of Reporting Persons.

        I.R.S. Identification Nos. of above persons (entities only).


        LAWRENCE M. ROBBINS

.................................................................................
2.      Check the Appropriate Box if a Member of a Group

        (a) [  ]

        (b) [  ]
.................................................................................
3.      SEC Use Only
.................................................................................
4.      Citizenship or Place of Organization

        United States of America
.................................................................................
Number of        5.   Sole Voting Power                None
Shares           ...............................................................
Beneficially     6.   Shared Voting Power              4,740,431
Owned by         ...............................................................
Each             7.   Sole Dispositive Power           None
Reporting        ...............................................................
Person With      8.   Shared Dispositive Power         4,740,431
.................................................................................
9.      Aggregate Amount Beneficially Owned by Each Reporting Person

        4,740,431
.................................................................................
10.     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

        [  ]
.................................................................................
11.     Percent of Class Represented by Amount in Row (9)

        4.97% based on 95,433,477 shares outstanding as of October 31, 2007
.................................................................................
12.     Type of Reporting Person:

        IN



                                                               Page 4 of 7 Pages


Item 1(a).      Name of Issuer:

                Ligand Pharmaceuticals, Inc. (the "Issuer")

Item 1(b).      Address of Issuer's Principal Executive Offices:

                10275 Science Center Drive, San Diego, CA 92121.

Item 2(a).      Name of Person Filing

                This Statement  is  filed  on  behalf  of each of the  following
persons (collectively, the "Reporting Persons"):

                i)  Glenview   Capital   Management,   LLC   ("Glenview  Capital
                Management");

                ii) Lawrence M. Robbins ("Mr. Robbins").

               This  Statement  relates  to  Shares (as defined herein) held for
the accounts of Glenview Capital Partners,  L.P., a Delaware limited partnership
("Glenview  Capital  Partners"),  Glenview  Capital Master Fund,  Ltd., a Cayman
Islands   exempted   company   ("Glenview   Capital  Master   Fund"),   Glenview
Institutional   Partners,   L.P.,  a  Delaware  limited  partnership  ("Glenview
Institutional  Partners"),  GCM Little Arbor Master Fund, Ltd., a Cayman Islands
exempted   company   ("GCM  Little  Arbor  Master   Fund"),   GCM  Little  Arbor
Institutional Partners,  L.P., a Delaware limited partnership ("GCM Little Arbor
Institutional  Partners") and GCM Little Arbor Partners, L.P. ("GCM Little Arbor
Partners"), a Delaware limited partnership.

               Glenview Capital  Management serves as investment manager to each
of  Glenview  Capital   Partners,   Glenview   Capital  Master  Fund,   Glenview
Institutional   Partners,  GCM  Little  Arbor  Master  Fund,  GCM  Little  Arbor
Institutional Partners and GCM Little Arbor Partners. In such capacity, Glenview
Capital  Management may be deemed to have voting and dispositive  power over the
Shares held for such  accounts.  Mr. Robbins is the Chief  Executive  Officer of
Glenview Capital Management.




                                                               Page 5 of 7 Pages


Item 2(b).      Address of Principal Business Office or, if None, Residence:

                The address of the principal business office of each of Glenview
Capital  Management and Mr. Robbins is 767 Fifth Avenue,  44th Floor,  New York,
New York 10153.

Item 2(c).      Citizenship:

                i)  Glenview  Capital Management is a Delaware limited liability
                company;

                ii) Mr. Robbins is a citizen of the United States of America.

Item 2(d).      Title of Class of Securities:

                Common Stock (the "Shares")

Item 2(e).      CUSIP Number:

                53220K207

Item 3.         If  This  Statement is  Filed Pursuant to  ss.ss.240.13d-1(b) or
                240.13d-2(b) or (c), Check Whether the Person Filing is a:

                  This Item 3 is not applicable.

Item 4.         Ownership:

Item 4(a)       Amount Beneficially Owned:

                As of December 31, 2007, each of Glenview Capital Management and
Mr. Robbins may be deemed to be the beneficial owner of 4,740,431  Shares.  This
amount consists of: (A) 384,054 Shares held for the account of Glenview  Capital
Partners;  (B) 1,523,970  Shares held for the account of Glenview Capital Master
Fund;  (C)  2,639,551  Shares  held for the  account of  Glenview  Institutional
Partners; (D) 111,400 Shares held for the account of the GCM Little Arbor Master
Fund;  (E) 77,064 Shares held for the account of GCM Little Arbor  Institutional
Partners;  and (F)  4,392  Shares  held  for the  account  of GCM  Little  Arbor
Partners.

Item 4(b)       Percent of Class:

                The   number  of  Shares  of  which  each  of  Glenview  Capital
Management and Mr. Robbins may be deemed to be the beneficial owner  constitutes
approximately  4.97% of the  total  number  of Shares  outstanding  (based  upon
information  provided by the Issuer in its most recently-filed  quarterly report
on Form 10-Q, there were 95,433,477 shares outstanding as of October 31, 2007).



                                                               Page 6 of 7 Pages


Item 4(c)      Number of Shares of which such person has:

Glenview Capital Management and Mr. Robbins:
--------------------------------------------

(i) Sole power to vote or direct the vote:                                     0
(ii) Shared power to vote or direct the vote:                          4,740,431
(iii) Sole power to dispose or direct the disposition of:                      0
(iv) Shared power to dispose or direct the disposition of:             4,740,431

Item 5.         Ownership of Five Percent or Less of a Class:

                If this statement  is being  filed to report the fact that as of
                the  date hereof  the  Reporting  Person  has  ceased  to be the
                beneficial owner  of more  than  five  percent  of the  class of
                securities, check the following [X].

Item 6.         Ownership of More than Five Percent on Behalf of Another Person:

                This Item 6 is not applicable.

Item 7.         Identification  and  Classification  of  the   Subsidiary  Which
                Acquired the Security  Being  Reported on By the Parent  Holding
                Company:

                See disclosure in Item 2 hereof.

Item 8.         Identification and Classification of Members of the Group:

                This Item 8 is not applicable.

Item 9.         Notice of Dissolution of Group:

                This Item 9 is not applicable.

Item 10.        Certification:

                By  signing  below each of the Reporting Persons certifies that,
to the best of their knowledge and belief, the securities referred to above were
not  acquired and are not held for the purpose of or with the effect of changing
or influencing the control of the issuer of the securities and were not acquired
and are not  held in  connection  with or as a  participant  in any  transaction
having that purpose or effect.



                                                               Page 7 of 7 Pages


                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Date: February 14, 2008                 GLENVIEW CAPITAL MANAGEMENT, LLC


                                        By:
                                           /s/ Lawrence M. Robbins
                                           -----------------------
                                        Name:  Lawrence M. Robbins
                                        Title: Chief Executive Officer


Date: February 14, 2008                 LAWRENCE M. ROBBINS


                                        /s/ Lawrence M. Robbins
                                        -----------------------