UNITED STATES
                        SECURITIES EXCHANGE COMMISSION
                            Washington, D.C. 20549

------------------------------------------------------------------------------


                                 SCHEDULE 13G

                   Under the Securities Exchange Act of 1934
                               (Amendment No. 2)

                      LIGAND PHARMACEUTICALS INCORPORATED
                      -----------------------------------
                               (Name of Issuer)


                   Common Stock, $0.001 par value per share
                   ----------------------------------------
                        (Title of Class of Securities)


                                   53220K207
                                --------------
                                (CUSIP Number)


                               December 31, 2006
                        ---------------------------------
            (Date of Event which Requires Filing of this Statement)


Check  the  appropriate  box to  designate  the rule  pursuant  to which  this
Schedule is filed:

                               [ ] Rule 13d-1(b)

                               [X] Rule 13d-1(c)

                               [ ] Rule 13d-1(d)

* The  remainder  of this  cover  page  shall be  filled  out for a  reporting
person's  initial  filing on this form with  respect to the  subject  class of
securities,  and for any subsequent  amendment  containing  information  which
would alter the disclosures provided in a prior cover page.

The  information  required  in the  remainder  of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities  Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however,  see
the Notes).


                         Continued on following pages
                               Page 1 of 9 Pages





                                 SCHEDULE 13G

CUSIP No.: 53220K207                                          Page 2 of 9 Pages

................................................................................

1. Names of Reporting Persons.

       I.R.S. Identification Nos. of above persons (entities only).



       GLENVIEW CAPITAL MANAGEMENT, LLC
................................................................................

2. Check the Appropriate Box if a Member of a Group

       (a) [ ]

       (b) [ ]
................................................................................

3. SEC Use Only

................................................................................

4. Citizenship or Place of Organization


       Delaware
................................................................................

Number of               5.      Sole Voting Power               None
Shares                  -------------------------------------------------------
Beneficially            6.      Shared Voting Power             7,322,288
Owned by Each           -------------------------------------------------------
Reporting               7.      Sole Dispositive Power          None
Person With             -------------------------------------------------------
                        8.      Shared Dispositive Power        7,322,288

................................................................................

9. Aggregate Amount Beneficially Owned by Each Reporting Person


       7,322,288
................................................................................

10.    Check if the Aggregate  Amount in Row (9) Excludes  Certain Shares (See
       Instructions)


       [  ]
................................................................................

11. Percent of Class Represented by Amount in Row (9)


       9.2% based on 79,229,629 shares outstanding as of October 31, 2006.
................................................................................

12. Type of Reporting Person:


       OO
................................................................................




                                 SCHEDULE 13G

CUSIP No.: 53220K207                                          Page 3 of 9 Pages


................................................................................

1. Names of Reporting Persons.

       I.R.S. Identification Nos. of above persons (entities only).



       GLENVIEW CAPITAL GP, LLC
................................................................................

2. Check the Appropriate Box if a Member of a Group

       (a) [ ]

       (b) [ ]
................................................................................

3. SEC Use Only

................................................................................

4. Citizenship or Place of Organization


       Delaware
................................................................................

Number of               5.      Sole Voting Power               None
Shares                  -------------------------------------------------------
Beneficially            6.      Shared Voting Power             7,322,288
Owned by Each           -------------------------------------------------------
Reporting               7.      Sole Dispositive Power          None
Person With             -------------------------------------------------------
                        8.      Shared Dispositive Power        7,322,288

................................................................................

9. Aggregate Amount Beneficially Owned by Each Reporting Person


      7,322,288
................................................................................

10.   Check if the Aggregate  Amount in Row (9) Excludes  Certain Shares (See
      Instructions)


      [  ]
................................................................................

11. Percent of Class Represented by Amount in Row (9)


      9.2% based on 79,229,629 shares outstanding as of October 31, 2006.

................................................................................

12. Type of Reporting Person:


      OO
................................................................................





                                 SCHEDULE 13G

CUSIP No.: 53220K207                                          Page 4 of 9 Pages

................................................................................

1. Names of Reporting Persons.

       I.R.S. Identification Nos. of above persons (entities only).



       GLENVIEW CAPITAL MASTER FUND, LTD.
................................................................................

2. Check the Appropriate Box if a Member of a Group

       (a) [ ]

       (b) [ ]
................................................................................

3. SEC Use Only

................................................................................

4. Citizenship or Place of Organization


       Cayman Islands, British West Indies
................................................................................

Number of               5.      Sole Voting Power               None
Shares                  -------------------------------------------------------
Beneficially            6.      Shared Voting Power             4,285,083
Owned by Each           -------------------------------------------------------
Reporting               7.      Sole Dispositive Power          None
Person With             -------------------------------------------------------
                        8.      Shared Dispositive Power        4,285,083

................................................................................

9. Aggregate Amount Beneficially Owned by Each Reporting Person


       4,285,083
................................................................................

10.    Check if the Aggregate  Amount in Row (9) Excludes  Certain Shares (See
       Instructions)


       [X]
................................................................................

11. Percent of Class Represented by Amount in Row (9)


       5.4% based on 79,229,629 shares outstanding as of October 31, 2006.
................................................................................

12. Type of Reporting Person:


       IA
................................................................................






                                 SCHEDULE 13G

CUSIP No.: 53220K207                                          Page 5 of 9 Pages

................................................................................

1. Names of Reporting Persons.

       I.R.S. Identification Nos. of above persons (entities only).



       LAWRENCE M. ROBBINS
................................................................................

2. Check the Appropriate Box if a Member of a Group

       (a) [ ]

       (b) [ ]
................................................................................

3. SEC Use Only

................................................................................

4. Citizenship or Place of Organization


       United States of America
................................................................................

Number of               5.      Sole Voting Power               None
Shares                  -------------------------------------------------------
Beneficially            6.      Shared Voting Power             7,322,288
Owned by Each           -------------------------------------------------------
Reporting               7.      Sole Dispositive Power          None
Person With             -------------------------------------------------------
                        8.      Shared Dispositive Power        7,322,288

................................................................................

9. Aggregate Amount Beneficially Owned by Each Reporting Person


       7,322,288
................................................................................

10.    Check if the Aggregate  Amount in Row (9) Excludes  Certain Shares (See
       Instructions)


       [  ]
................................................................................

11. Percent of Class Represented by Amount in Row (9)


       9.2% based on 79,229,629 shares outstanding as of October 31, 2006.
................................................................................

12. Type of Reporting Person:


       IA
................................................................................









                                                              Page 6 of 9 Pages

Item 1(a).      Name of Issuer:

                Ligand Pharmaceuticals Incorporated (the "Issuer")

Item 1(b).      Address of Issuer's Principal Executive Offices:

                10275 Science Center Drive, San Diego, CA 92121-1117.

Item 2(a).      Name of Person Filing:

                This  Statement  is filed on behalf  of each of the  following
                persons (collectively, the "Reporting Persons"):

                i)      Glenview Capital Management, LLC ("Glenview Capital
                        Management");

                ii)     Glenview Capital GP, LLC ("Glenview Capital GP");

                iii)    Glenview Capital Master Fund, Ltd. ("Glenview Capital
                        Master Fund); and

                iv)     Lawrence M. Robbins ("Mr. Robbins").

            This Statement  relates to Shares (as defined herein) held for the
accounts of Glenview Capital  Partners,  L.P., a Delaware limited  partnership
("Glenview  Capital  Partners"),  Glenview  Institutional  Partners,  L.P.,  a
Delaware limited partnership  ("Glenview  Institutional  Partners"),  Glenview
Capital  Master  Fund, a Cayman  Islands  exempted  company,  GCM Little Arbor
Master Fund, Ltd., a Cayman Islands exempted company ("GCM Little Arbor Master
Fund"),  GCM Little Arbor  Institutional  Partners,  L.P., a Delaware  limited
partnership ("GCM Little Arbor Institutional Partners"),  and GCM Little Arbor
Partners, L.P., a Delaware limited partnership ("GCM Little Arbor Partners").

            Glenview Capital  Management serves as investment  manager to each
of  Glenview  Capital  Partners,  Glenview  Institutional  Partners,  Glenview
Capital   Master  Fund,  GCM  Little  Arbor  Master  Fund,  GCM  Little  Arbor
Institutional  Partners,  and GCM Little  Arbor  Partners.  In such  capacity,
Glenview Capital Management may be deemed to have voting and dispositive power
over the Shares held for the  accounts of each of Glenview  Capital  Partners,
Glenview  Institutional  Partners,  Glenview  Capital  Master Fund, GCM Little
Arbor Master Fund,  GCM Little Arbor  Institutional  Partners,  and GCM Little
Arbor Partners. Glenview Capital GP is the general partner of Glenview Capital
Partners,  Glenview  Institutional  Partners,  GCM Little Arbor  Institutional
Partners and GCM Little Arbor Partners. Glenview Capital GP also serves as the
sponsor of the  Glenview  Capital  Master Fund and the GCM Little Arbor Master
Fund. In such capacities, Glenview Capital GP may be deemed to have voting and
dispositive  power over the Shares  held for the  accounts of each of Glenview
Capital Partners,  Glenview  Institutional  Partners,  Glenview Capital Master
Fund, GCM Little Arbor Master Fund, GCM Little Arbor  Institutional  Partners,
and GCM Little Arbor Partners.  Mr. Robbins is the Chief Executive  Officer of
Glenview Capital Management and Glenview Capital GP.

Item 2(b).   Address of Principal Business Office or, if None, Residence

            The address of the principal  business  office of each of Glenview
Capital Management,  Glenview Capital GP, and Mr. Robbins is 767 Fifth Avenue,
44th Floor,  New York, New York 10153.  The address of the principal  business
office of Glenview Capital Master Fund is Harbour Centre, North Church Street,
P.O. Box 8966T,  George  Town,  Grand  Cayman,  Cayman  Islands,  British West
Indies.





                                                              Page 7 of 9 Pages



Item 2(c).      Citizenship:

                i)      Glenview  Capital  Management  is a  Delaware  limited
                        liability company;

                ii)     Glenview  Capital GP is a Delaware  limited  liability
                        company;

                iii)    Glenview  Capital  Master  Fund  is a  Cayman  Islands
                        exempted company; and

                iv)     Mr.  Robbins  is a  citizen  of the  United  States of
                        America.

Item 2(d).      Title of Class of Securities:

                Common Stock, $0.001 par value per share (the "Shares")

Item 2(e).      CUSIP Number:

                53220K207

Item 3.         If This Statement is Filed  Pursuant to  ss.ss.240.13d-1(b) or
                240.13d-2(b) or (c), Check Whether the Person Filing is a:

                This Item 3 is not applicable.

Item 4.         Ownership:

Item 4(a).      Amount Beneficially Owned:

               (i)  As  of  December  29,  2006,  each  of  Glenview   Capital
Management,  Glenview  Capital  GP and Mr.  Robbins  may be  deemed  to be the
beneficial  owner of 7,312,288  Shares.  This amount  consists of: (A) 344,354
Shares held for the account of Glenview Capital Partners; (B) 4,285,083 Shares
held for the account of Glenview  Capital  Master Fund;  (C) 1,996,951  Shares
held for the account of Glenview  Institutional  Partners;  (D) 538,444 Shares
held for the account of GCM Little Arbor Master Fund,  (E) 148,730 Shares held
for the  account of GCM Little  Arbor  Institutional  Partners,  and (F) 8,726
Shares held for the account of GCM Little Arbor Partners.

               (ii) As of December 29, 2006,  Glenview Capital Master Fund may
be deemed to be the beneficial owner of 4,285,083 Shares. This amount consists
of 4,285,083 Shares held for its account.

Item 4(b)      Percent of Class:

               (i) The  number  of Shares of which  each of  Glenview  Capital
Management,  Glenview  Capital  GP and Mr.  Robbins  may be  deemed  to be the
beneficial owner constitutes  approximately 9.2% of the total number of Shares
outstanding  (based  upon  information  provided  by the  Issuer  in its  most
recently-filed  quarterly  report  on  Form  10-Q,  there  were  approximately
79,229,629 shares outstanding as of October 31, 2006).

               (ii) The number of Shares of which Glenview Capital Master Fund
may be deemed to be the beneficial owner constitutes approximately 5.4% of the
total number of Shares  outstanding  (based upon  information  provided by the
Issuer in its most  recently-filed  quarterly  report on Form 10-Q, there were
approximately 79,229,629 shares outstanding as of October 31, 2006).



                                                              Page 8 of 9 Pages




Item 4(c) Number of Shares of which such person has:

Glenview Capital Management, Glenview Capital GP, and Mr. Robbins:
------------------------------------------------------------------

(i) Sole power to vote or direct the vote:                                    0

(ii) Shared power to vote or direct the vote:                         7,322,288

(iii) Sole power to dispose or direct the disposition of:                     0

(iv) Shared power to dispose or direct the disposition of:            7,322,288


Glenview Capital Master Fund:
-----------------------------

(i) Sole power to vote or direct the vote:                                    0

(ii) Shared power to vote or direct the vote:                         4,285,083

(iii) Sole power to dispose or direct the disposition of:                     0

(iv) Shared power to dispose or direct the disposition of:            4,285,083


Item 5.         Ownership of Five Percent or Less of a Class:

                This Item 5 is not applicable

Item 6.         Ownership of More than Five Percent on Behalf of Another Person:

                This Item 6 is not applicable

Item 7.         Identification and Classification of the Subsidiary Which
                Acquired the Security Being Reported on By the Parent Holding
                Company:

                See disclosure in Item 2 hereof.

Item 8.         Identification and Classification of Members of the Group:

                See disclosure in Item 2 hereof.

Item 9.         Notice of Dissolution of Group:

                This Item 9 is not applicable.

Item 10.        Certification:

            By signing below each of the Reporting  Persons certifies that, to
the best of their knowledge and belief, the securities  referred to above were
not  acquired  and are not  held for the  purpose  of or with  the  effect  of
changing or  influencing  the control of the issuer of the securities and were
not acquired and are not held in connection  with or as a  participant  in any
transaction having that purpose or effect.





                                                              Page 9 of 9 Pages




                                   SIGNATURE

      After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date: February 14, 2007              GLENVIEW CAPITAL MANAGEMENT, LLC


                                      By: /s/ Lawrence M. Robbins
                                        -----------------------------
                                     Name:  Lawrence M. Robbins
                                     Title: Chief Executive Officer

Date: February 14, 2007              GLENVIEW CAPITAL GP, LLC


                                      By: /s/ Lawrence M. Robbins
                                        -----------------------------
                                     Name:  Lawrence M. Robbins
                                     Title: Chief Executive Officer

Date: February 14, 2007              GLENVIEW CAPITAL MASTER FUND, LTD.

                                     By:  Glenview Capital Management, LLC
                                         As Investment Manager


                                      By: /s/ Lawrence M. Robbins
                                        -----------------------------
                                     Name:  Lawrence M. Robbins
                                     Title: Chief Executive Officer

Date: February 14, 2007              LAWRENCE M. ROBBINS


                                     /s/ Lawrence M. Robbins
                                     --------------------------------