UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 2)*

           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
                   RULE 13D-1(a) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13D-2(a)

                               INCYTE CORPORATION
--------------------------------------------------------------------------------
                                (Name of Issuer)

                         COMMON STOCK, $0.001 PER SHARE
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   45337C-10-2
      ---------------------------------------------------------------------
                                 (CUSIP Number)


                                 BARRY L. BLOOM
                         655 MADISON AVENUE, 19TH FLOOR
                             NEW YORK, NY 10021-8043
                                 (212) 521-2930
--------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)

                                FEBRUARY 19, 2004
      ---------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Rule  13d-1(e),  13d-1(f) or 13d-1(g),  check the following
box. [ ]

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 (the "Act") or otherwise  subject to the liabilities of that section of the
Act but shall be subject to all other  provisions of the Act  (however,  see the
Notes).

                               Page 1 of 13 Pages



                                  SCHEDULE 13D

----------------------------------          ------------------------------------
 CUSIP NO. 45337C-10-2                             PAGE 2 OF 13 PAGES
----------------------------------          ------------------------------------
--------------------------------------------------------------------------------
 1      NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

               Andrew H. Tisch
--------------------------------------------------------------------------------
 2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (See Instructions)                                               (a) [_]
                                                                         (b) [X]
--------------------------------------------------------------------------------
 3      SEC USE ONLY
--------------------------------------------------------------------------------
 4      SOURCE OF FUNDS (See Instructions)

               PF
--------------------------------------------------------------------------------
 5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
        PURSUANT TO ITEMS 2(d) OR 2(e)                                       [_]
--------------------------------------------------------------------------------
 6      CITIZENSHIP OR PLACE OF ORGANIZATION

        United States
--------------------------------------------------------------------------------
                    7    SOLE VOTING POWER

                              -0-
                    ------------------------------------------------------------
   NUMBER OF        8    SHARED VOTING POWER
    SHARES
 BENEFICIALLY                 3,152,554
   OWNED BY         ------------------------------------------------------------
     EACH           9    SOLE DISPOSITIVE POWER
   REPORTING
 PERSON WITH                  -0-
                    ------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER

                              3,152,554
--------------------------------------------------------------------------------
11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               3,152,554
--------------------------------------------------------------------------------
12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
        EXCLUDES CERTAIN SHARES (See Instructions)                           [_]
--------------------------------------------------------------------------------
13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               4.4%
--------------------------------------------------------------------------------
14      TYPE OF REPORTING PERSON (See Instructions)

               IN
--------------------------------------------------------------------------------



                                  SCHEDULE 13D

----------------------------------          ------------------------------------
 CUSIP NO. 45337C-10-2                             PAGE 3 OF 13 PAGES
----------------------------------          ------------------------------------
--------------------------------------------------------------------------------
 1      NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

               Daniel R. Tisch
--------------------------------------------------------------------------------
 2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (See Instructions)                                               (a) [_]
                                                                         (b) [X]
--------------------------------------------------------------------------------
 3      SEC USE ONLY
--------------------------------------------------------------------------------
 4      SOURCE OF FUNDS (See Instructions)

               PF
--------------------------------------------------------------------------------
 5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
        PURSUANT TO ITEMS 2(d) OR 2(e)                                       [_]
--------------------------------------------------------------------------------
 6      CITIZENSHIP OR PLACE OF ORGANIZATION

        United States
--------------------------------------------------------------------------------
                    7    SOLE VOTING POWER

                              -0-
                    ------------------------------------------------------------
   NUMBER OF        8    SHARED VOTING POWER
    SHARES
 BENEFICIALLY                 3,152,554
   OWNED BY         ------------------------------------------------------------
     EACH           9    SOLE DISPOSITIVE POWER
   REPORTING
 PERSON WITH                  -0-
                    ------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER

                              3,152,554
--------------------------------------------------------------------------------
11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               3,152,554
--------------------------------------------------------------------------------
12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
        EXCLUDES CERTAIN SHARES (See Instructions)                           [_]
--------------------------------------------------------------------------------
13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               4.4%
--------------------------------------------------------------------------------
14      TYPE OF REPORTING PERSON (See Instructions)

               IN
--------------------------------------------------------------------------------



                                  SCHEDULE 13D

----------------------------------          ------------------------------------
 CUSIP NO. 45337C-10-2                             PAGE 4 OF 13 PAGES
----------------------------------          ------------------------------------
--------------------------------------------------------------------------------
 1      NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

               James S. Tisch
--------------------------------------------------------------------------------
 2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (See Instructions)                                               (a) [_]
                                                                         (b) [X]
--------------------------------------------------------------------------------
 3      SEC USE ONLY
--------------------------------------------------------------------------------
 4      SOURCE OF FUNDS (See Instructions)

               PF
--------------------------------------------------------------------------------
 5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
        PURSUANT TO ITEMS 2(d) OR 2(e)                                       [_]
--------------------------------------------------------------------------------
 6      CITIZENSHIP OR PLACE OF ORGANIZATION

        United States
--------------------------------------------------------------------------------
                    7    SOLE VOTING POWER

                              -0-
                    ------------------------------------------------------------
   NUMBER OF        8    SHARED VOTING POWER
    SHARES
 BENEFICIALLY                 3,152,554
   OWNED BY         ------------------------------------------------------------
     EACH           9    SOLE DISPOSITIVE POWER
   REPORTING
 PERSON WITH                  -0-
                    ------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER

                              3,152,554
--------------------------------------------------------------------------------
11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               3,152,554
--------------------------------------------------------------------------------
12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
        EXCLUDES CERTAIN SHARES (See Instructions)                           [_]
--------------------------------------------------------------------------------
13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               4.4%
--------------------------------------------------------------------------------
14      TYPE OF REPORTING PERSON (See Instructions)

               IN
--------------------------------------------------------------------------------



                                  SCHEDULE 13D

----------------------------------          ------------------------------------
 CUSIP NO. 45337C-10-2                             PAGE 5 OF 13 PAGES
----------------------------------          ------------------------------------
--------------------------------------------------------------------------------
 1      NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

               Thomas J. Tisch
--------------------------------------------------------------------------------
 2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (See Instructions)                                               (a) [_]
                                                                         (b) [X]
--------------------------------------------------------------------------------
 3      SEC USE ONLY
--------------------------------------------------------------------------------
 4      SOURCE OF FUNDS (See Instructions)

               PF
--------------------------------------------------------------------------------
 5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
        PURSUANT TO ITEMS 2(d) OR 2(e)                                       [_]
--------------------------------------------------------------------------------
 6      CITIZENSHIP OR PLACE OF ORGANIZATION

        United States
--------------------------------------------------------------------------------
                    7    SOLE VOTING POWER

                              -0-
                    ------------------------------------------------------------
   NUMBER OF        8    SHARED VOTING POWER
    SHARES
 BENEFICIALLY                 3,352,554
   OWNED BY         ------------------------------------------------------------
     EACH           9    SOLE DISPOSITIVE POWER
   REPORTING
 PERSON WITH                  -0-
                    ------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER

                              3,352,554
--------------------------------------------------------------------------------
11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               3,352,554
--------------------------------------------------------------------------------
12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
        EXCLUDES CERTAIN SHARES (See Instructions)                           [_]
--------------------------------------------------------------------------------
13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               4.6%
--------------------------------------------------------------------------------
14      TYPE OF REPORTING PERSON (See Instructions)

               IN
--------------------------------------------------------------------------------



                                  SCHEDULE 13D

----------------------------------          ------------------------------------
 CUSIP NO. 45337C-10-2                             PAGE 6 OF 13 PAGES
----------------------------------          ------------------------------------
--------------------------------------------------------------------------------
 1      NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

               Julian C. Baker
--------------------------------------------------------------------------------
 2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (See Instructions)                                               (a) [_]
                                                                         (b) [X]
--------------------------------------------------------------------------------
 3      SEC USE ONLY
--------------------------------------------------------------------------------
 4      SOURCE OF FUNDS (See Instructions)

               PF
--------------------------------------------------------------------------------
 5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
        PURSUANT TO ITEMS 2(d) OR 2(e)                                       [_]
--------------------------------------------------------------------------------
 6      CITIZENSHIP OR PLACE OF ORGANIZATION

        United States
--------------------------------------------------------------------------------
                    7    SOLE VOTING POWER

                              27,917
                    ------------------------------------------------------------
   NUMBER OF        8    SHARED VOTING POWER
    SHARES
 BENEFICIALLY                 4,580,344
   OWNED BY         ------------------------------------------------------------
     EACH           9    SOLE DISPOSITIVE POWER
   REPORTING
 PERSON WITH                  27,917
                    ------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER

                              4,580,344
--------------------------------------------------------------------------------
11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               4,608,261
--------------------------------------------------------------------------------
12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
        EXCLUDES CERTAIN SHARES (See Instructions)                           [_]
--------------------------------------------------------------------------------
13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               6.2%
--------------------------------------------------------------------------------
14      TYPE OF REPORTING PERSON (See Instructions)

               IN
--------------------------------------------------------------------------------



                                  SCHEDULE 13D

----------------------------------          ------------------------------------
 CUSIP NO. 45337C-10-2                             PAGE 7 OF 13 PAGES
----------------------------------          ------------------------------------
--------------------------------------------------------------------------------
 1      NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

               Felix J. Baker
--------------------------------------------------------------------------------
 2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (See Instructions)                                               (a) [_]
                                                                         (b) [X]
--------------------------------------------------------------------------------
 3      SEC USE ONLY
--------------------------------------------------------------------------------
 4      SOURCE OF FUNDS (See Instructions)

               PF
--------------------------------------------------------------------------------
 5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
        PURSUANT TO ITEMS 2(d) OR 2(e)                                       [_]
--------------------------------------------------------------------------------
 6      CITIZENSHIP OR PLACE OF ORGANIZATION

        United States
--------------------------------------------------------------------------------
                    7    SOLE VOTING POWER

                              -0-
                    ------------------------------------------------------------
   NUMBER OF        8    SHARED VOTING POWER
    SHARES
 BENEFICIALLY                 4,580,344
   OWNED BY         ------------------------------------------------------------
     EACH           9    SOLE DISPOSITIVE POWER
   REPORTING
 PERSON WITH                  -0-
                    ------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER

                              4,580,344
--------------------------------------------------------------------------------
11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               4,580,344
--------------------------------------------------------------------------------
12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
        EXCLUDES CERTAIN SHARES (See Instructions)                           [_]
--------------------------------------------------------------------------------
13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               6.2%
--------------------------------------------------------------------------------
14      TYPE OF REPORTING PERSON (See Instructions)

               IN
--------------------------------------------------------------------------------



         This Amendment No. 2 (the "Amendment") to Schedule 13D is being filed
by Andrew H. Tisch, Daniel R. Tisch, James S. Tisch, Thomas J. Tisch, Julian C.
Baker and Felix J. Baker (the "Reporting Persons") to amend and supplement the
statement on Schedule 13D previously filed by the Reporting Persons. Except as
amended and supplemented therein, that statement remains in full force and
effect.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER.

         Because of certain business and family relationships among the
Reporting Persons, they are filing as if they constitute a group solely for
informational purposes. However, the filing of this statement is not an
admission by any Reporting Person that such Reporting Person and any other
Reporting Person or Reporting Persons constitute a "group" for purposes of
Section 13(d)(3) of the Securities Exchange Act of 1934, as amended, or Rule
13d-5 thereunder. Each Reporting Person disclaims beneficial ownership of any
shares of Common Stock owned by any other Reporting Person, except to the extent
that beneficial ownership is expressly reported herein.

         Set forth in the table below is the aggregate number of shares of
Common Stock owned, including shares that may be acquired upon conversion or
exercise of convertible securities or options within 60 days, by each of the
following on February 19, 2004, together with the percentage of outstanding
shares of Common Stock that such ownership represents.

                                      NUMBER OF SHARES       PERCENT OF CLASS
NAME                                      OWNED              OUTSTANDING (1)
-----------------------------         ----------------       ----------------


Four Partners                            2,755,513                    3.8%
Four-Fourteen Partners, LLC                200,000                    0.3%
Andrew H. Tisch (2)                        397,041                    0.5%
Daniel R. Tisch (2)                        397,041                    0.5%
James S. Tisch (2)                         397,041                    0.5%
Thomas J. Tisch (2)                        397,041                    0.5%
Baker/Tisch Investments, L.P.              278,593                    0.4%
Baker Bros. Investments, L.P.              208,814                    0.3%
Baker Bros. Investments II, L.P.           128,640                    0.2%
Baker Biotech Fund I, L.P.               2,174,811                    3.0%
Baker Biotech Fund II, L.P.              1,661,628                    2.3%
Baker Biotech Fund II (Z), L.P.             72,200                    0.1%
FBB Associates                              55,658                    0.1%
Julian C. Baker                             27,917 (3)                0.0%

Total                                    9,151,938                   12.4%

(1)      The ownership percentages set forth in the table above are based upon
         72,456,424 shares of Common Stock outstanding, as reported on the
         Company's Form 10-Q for the fiscal quarter ended October 31, 2003, plus
         any shares that may be acquired upon conversion of 5.5% Convertible
         Subordinated Notes due 2007 at the presently applicable conversion

                               Page 8 of 13 Pages




         price of $67.4195, plus any shares that may be acquired upon conversion
         of 3.5% Convertible Subordinated Notes due 2011 at the presently
         applicable conversion price of $11.2185, plus any shares that may be
         acquired upon exercise of stock options.

(2)      Includes shares held by the Reporting Person in his individual capacity
         or by a trust in which the Reporting Person is the trustee or managing
         trustee and has voting or investment control over securities held by
         such trust.

(3)      Represents shares that may be acquired upon exercise of non-qualified
         stock options.


         Each person listed above has sole power to vote or direct the vote of
and to dispose or direct the disposition of the securities listed after such
person's name, except as follows:

(1)      By virtue of their status as managing trustees of the trusts that are
         the general partners of Four Partners, a New York general partnership,
         Andrew H. Tisch, Daniel R. Tisch, James S. Tisch and Thomas J. Tisch
         may be deemed to have shared beneficial ownership of securities owned
         by Four Partners and shared power to vote or direct the vote of and to
         dispose or direct the disposition of such securities.

(2)      By virtue of his status as manager of Four-Fourteen Partners, LLC,
         Thomas J. Tisch may be deemed to be the beneficial owner of securities
         owned by Four-Fourteen Partners, LLC and to have power to vote or
         direct the vote of and to dispose or direct the disposition of
         securities owned by Four-Fourteen Partners, LLC.

(3)      Julian C. Baker and Felix J. Baker, by virtue of their control of
         entities that have the power to control the investment decisions of
         Baker/Tisch Investments, L.P., Baker Bros. Investments, L.P., Baker
         Bros. Investments II, L.P., Baker Biotech Fund I, L.P., Baker Biotech
         Fund II, L.P. and Baker Biotech Fund II (Z), L.P., may each be deemed
         to be the beneficial owners of securities owned by such entities and
         may be deemed to have shared power to vote or direct the vote of and to
         dispose or direct the disposition of such securities. Julian C. Baker
         and Felix J. Baker are also the sole partners of FBB Associates, a
         general partnership, and as such may be deemed to be beneficial owners
         of securities owned by FBB Associates and to have shared power to vote
         or direct the vote of and to dispose or direct the disposition of such
         securities.

                  The following sales of 5.5% Convertible Subordinated Notes due
2007 were effected by the entities noted below during the 60 days preceding the
date hereof. The following transactions were effected with broker dealers on the
over the counter market.

NAME                              DATE            PRINCIPAL AMOUNT       PRICE
---------------------------     --------          ----------------       ------
Andrew H. Tisch                 01/14/04               $400,000          90.75%
Daniel R. Tisch                 01/14/04               $400,000          90.75%
James S. Tisch                  01/14/04               $400,000          90.75%

                              Page 9 of 13 Pages


NAME                              DATE            PRINCIPAL AMOUNT       PRICE
---------------------------     --------          ----------------       ------
Thomas J. Tisch                 01/14/04               $400,000          90.75%
Damial Foundation Inc.          01/14/04               $135,000          90.75%
Bonnie J. Tisch                 01/14/04                $30,000          90.75%
Andrew H. Tisch                 02/03/04               $800,000          91.75%
Daniel R. Tisch                 02/03/04               $800,000          91.75%
James S. Tisch                  02/03/04               $800,000          91.75%
Thomas J. Tisch                 02/03/04               $800,000          91.75%
Damial Foundation Inc.          02/03/04               $200,000          91.75%
Andrew H. Tisch                 02/09/04             $2,250,000          91.92%
Daniel R. Tisch                 02/09/04             $2,250,000          91.92%
James S. Tisch                  02/09/04             $2,250,000          91.92%
Thomas J. Tisch                 02/09/04             $2,250,000          91.92%
Andrew H. Tisch                 02/10/04             $4,730,000          92.85%
Daniel R. Tisch                 02/10/04             $4,730,000          92.85%
James S. Tisch                  02/10/04             $4,730,000          92.85%
Thomas J. Tisch                 02/10/04             $4,730,000          92.85%
Damial Foundation Inc.          02/10/04             $2,080,000          92.85%
Andrew H. Tisch                 02/11/04             $1,000,000          93.30%
Andrew H. Tisch                 02/11/04             $1,237,500          97.75%
Andrew H. Tisch                 02/11/04             $3,237,500          98.25%
Daniel R. Tisch                 02/11/04             $1,000,000          93.30%
Daniel R. Tisch                 02/11/04             $1,237,500          97.75%
Daniel R. Tisch                 02/11/04             $3,237,500          98.25%
James S. Tisch                  02/11/04             $1,000,000          93.30%
James S. Tisch                  02/11/04             $1,237,500          97.75%
James S. Tisch                  02/11/04             $3,237,500          98.25%
Thomas J. Tisch                 02/11/04             $1,000,000          93.30%
Thomas J. Tisch                 02/11/04             $1,237,500          97.75%

                              Page 10 of 13 Pages


NAME                              DATE            PRINCIPAL AMOUNT       PRICE
---------------------------     --------          ----------------       ------
Thomas J. Tisch                 02/11/04             $3,237,500          98.25%
Damial Foundation Inc.          02/11/04             $1,150,000          97.75%
DMA Family Partnership          02/11/04                $73,000          97.75%
Andrew H. Tisch                 02/12/04             $3,500,000          99.00%
Daniel R. Tisch                 02/12/04             $3,500,000          99.00%
James S. Tisch                  02/12/04             $3,500,000          99.00%
Thomas J. Tisch                 02/12/04             $3,500,000          99.00%

         The following 3.5% Convertible Subordinated Notes due 2011 were
purchased in a Rule 144A offering from Morgan Stanley & Co. Incorporated by the
entities set forth below during the 60 days preceding the date hereof. The notes
are convertible to Common Stock at the presently applicable conversion price of
$11.2185.

NAME                              DATE            PRINCIPAL AMOUNT       PRICE
---------------------------     --------          ----------------       ------
Baker Biotech Fund I, L.P.      02/19/04            $7,793,000            100%
Baker Biotech Fund II, L.P.     02/19/04            $7,207,000            100%



ITEM 7.   MATERIAL TO BE FILED AS EXHIBITS.

Exhibit 1.     Agreement regarding the joint filing of this statement.










                              Page 11 of 13 pages



                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

February 24, 2004


                                       By: /s/ Andrew H. Tisch
                                           -------------------------------------
                                            Andrew H. Tisch

                                       By: /s/ Daniel R. Tisch
                                           -------------------------------------
                                            Daniel R. Tisch

                                       By: /s/ James S. Tisch
                                           -------------------------------------
                                            James S. Tisch

                                       By: /s/ Thomas J. Tisch
                                           -------------------------------------
                                            Thomas J. Tisch

                                       By: /s/ Bonnie J. Tisch
                                           -------------------------------------
                                            Bonnie J. Tisch

                                       By: /s/ Julian C. Baker
                                           -------------------------------------
                                            Julian C. Baker

                                       By: /s/ Felix J. Baker
                                           -------------------------------------
                                            Felix J. Baker


                              Page 12 of 13 Pages





                                                                       EXHIBIT 1


                                    AGREEMENT

         In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act
of 1934, as amended, the undersigned hereby agree that this Statement on
Schedule 13D relating to the Common Stock, par value $0.001 per share, of Incyte
Corporation, and such other amendments as may be filed by them hereafter, are
being filed with the Securities and Exchange Commission on behalf of each of
them.

February 24, 2004

                                       By: /s/ Andrew H. Tisch
                                           -------------------------------------
                                            Andrew H. Tisch

                                       By: /s/ Daniel R. Tisch
                                           -------------------------------------
                                            Daniel R. Tisch

                                       By: /s/ James S. Tisch
                                           -------------------------------------
                                            James S. Tisch

                                       By: /s/ Thomas J. Tisch
                                           -------------------------------------
                                            Thomas J. Tisch

                                       By: /s/ Bonnie J. Tisch
                                           -------------------------------------
                                            Bonnie J. Tisch

                                       By: /s/ Julian C. Baker
                                           -------------------------------------
                                            Julian C. Baker

                                       By: /s/ Felix J. Baker
                                           -------------------------------------
                                            Felix J. Baker





                              Page 13 of 13 Pages