Form N-Q

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

FORM N-Q


QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number         811-7616         

        Nuveen Missouri Premium Income Municipal Fund         
(Exact name of registrant as specified in charter)

Nuveen Investments
        333 West Wacker Drive, Chicago, Illinois 60606         
(Address of principal executive offices) (Zip code)


Kevin J. McCarthy Vice President and Secretary
        333 West Wacker Drive, Chicago, Illinois 60606         
(Name and address of agent for service)

Registrant's telephone number, including area code:         312-917-7700        

Date of fiscal year end:            5/31          

Date of reporting period:         2/29/08         

Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (§§ 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.

A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. § 3507.

Item 1. Schedule of Investments

    Portfolio of Investments (Unaudited)             
    Nuveen Missouri Premium Income Municipal Fund (NOM)             
    February 29, 2008             
Principal        Optional Call         
Amount (000)    Description (1)    Provisions (2)    Ratings (3)    Value 
    Consumer Staples – 3.3% (2.1% of Total Investments)             
$          1,000    Missouri Development Finance Board, Solid Waste Disposal Revenue Bonds, Procter and Gamble    No Opt. Call    AA–   $   979,930 
     Inc., Series 1999, 5.200%, 3/15/29 (Alternative Minimum Tax)             
    Education and Civic Organizations – 3.8% (2.4% of Total Investments)             
250    Lincoln University, Missouri, Auxillary System Revenue Bonds, Series 2007, 5.125%, 6/01/37 –    6/17 at 100.00    AAA    238,513 
     AGC Insured             
500    Missouri Health and Educational Facilities Authority, Revenue Bonds, St. Louis Priory School,    8/08 at 101.00    A3    501,355 
     Series 2000, 5.650%, 2/01/25             
365    Missouri Health and Educational Facilities Authority, Revenue Bonds, Webster University,    4/11 at 100.00    Aaa    381,126 
     Series 2001, 5.500%, 4/01/18 – MBIA Insured             
1,115    Total Education and Civic Organizations            1,120,994 
    Health Care – 20.3% (13.0% of Total Investments)             
710    Cape Girardeau County Industrial Development Authority, Missouri, Health Facilities Revenue    6/17 at 100.00    N/R    607,093 
     Bonds, Southeast Missouri Hospital Association, Series 2007, 5.000%, 6/01/27             
480    Cass County, Missouri, Hospital Revenue Bonds, Series 2007, 5.625%, 5/01/38    11/16 at 100.00    N/R    423,000 
480    Clinton County Industrial Development Authority, Missouri, Revenue Bonds, Cameron Regional    12/17 at 100.00    N/R    367,046 
     Medical Center, Series 2007, 5.000%, 12/01/37             
750    Joplin Industrial Development Authority, Missouri, Health Facilities Revenue Bonds, Freeman    2/15 at 102.00    BBB+    706,433 
     Health System, Series 2004, 5.500%, 2/15/29             
500    Missouri Health & Educational Facilities Authority, Saint Lukes Episcopal-Presbyterian    6/11 at 101.00    AAA    489,450 
     Hospitals Revenue Bonds, Series 2001, 5.250%, 12/01/26 – FSA Insured             
    Missouri Health and Educational Facilities Authority, Revenue Bonds, BJC Health System, Series 2003:             
1,500     5.125%, 5/15/25    5/13 at 100.00    AA    1,428,180 
1,155     5.250%, 5/15/32    5/13 at 100.00    AA    1,100,195 
425    Missouri Health and Educational Facilities Authority, Revenue Bonds, Lake Regional Health    8/08 at 100.00    BBB+    425,272 
     System, Series 1996, 6.500%, 2/15/21             
500    Missouri Health and Educational Facilities Authority, Revenue Bonds, Lake Regional Health    2/14 at 100.00    BBB+    475,335 
     System, Series 2003, 5.700%, 2/15/34             
6,500    Total Health Care            6,022,004 
    Housing/Multifamily – 6.5% (4.1% of Total Investments)             
295    Missouri Housing Development Commission, Multifamily Housing Revenue Bonds, Series 2001II,    12/11 at 100.00    AA    304,416 
     5.250%, 12/01/16             
500    St. Charles County Industrial Development Authority, Missouri, FHA-Insured Multifamily Housing    4/08 at 102.00    AAA    476,255 
     Revenue Bonds, Ashwood Apartments, Series 1998A, 5.600%, 4/01/30 – FSA Insured (Alternative             
     Minimum Tax)             
515    St. Louis County Industrial Development Authority, Missouri, GNMA Collateralized Multifamily    4/08 at 101.00    AAA    527,159 
     Housing Revenue Refunding Bonds, South Summit Apartments, Series 1997A, 5.950%, 4/20/17             
600    St. Louis County Industrial Development Authority, Missouri, GNMA Collateralized Multifamily    4/08 at 101.00    AAA    614,184 
     Housing Revenue Refunding Bonds, South Summit Apartments, Series 1997B, 6.000%, 10/20/15             
     (Alternative Minimum Tax)             
1,910    Total Housing/Multifamily            1,922,014 
    Housing/Single Family – 8.7% (5.5% of Total Investments)             
15    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    3/08 at 103.00    AAA    15,254 
     Loan Program, Series 1995C, 7.250%, 9/01/26 (Alternative Minimum Tax)             
90    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    3/10 at 100.00    AAA    92,228 
     Loan Program, Series 2000B-1, 6.250%, 3/01/31 (Alternative Minimum Tax)             
730    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    3/16 at 104.50    AAA    747,089 
     Loan Program, Series 2006E-1, 5.600%, 3/01/37 (Alternative Minimum Tax)             
980    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    9/16 at 100.00    AAA    861,312 
     Loan Program, Series 2007A-1, 4.700%, 9/01/27 (Alternative Minimum Tax)             
1,000    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    3/17 at 100.00    AAA    855,190 
     Loan Program, Series 2007C-1, 4.800%, 9/01/38 (Alternative Minimum Tax)             
2,815    Total Housing/Single Family            2,571,073 
    Long-Term Care – 8.4% (5.4% of Total Investments)             
1,750    Cole County Industrial Development Authority, Missouri, Revenue Bonds, Lutheran Senior    2/14 at 100.00    N/R    1,627,168 
     Services – Heisinger Project, Series 2004, 5.500%, 2/01/35             
475    Lees Summit Industrial Development Authority, Missouri, Revenue Bonds, John Knox Village    8/17 at 100.00    N/R    416,523 
     Obligated Group, Series 2007A, 5.125%, 8/15/32             
500    St. Louis County Industrial Development Authority, Missouri, Revenue Bonds, Friendship Village    9/17 at 100.00    N/R    446,130 
     of West County, Series 2007A, 5.500%, 9/01/28             
2,725    Total Long-Term Care            2,489,821 
    Materials – 2.2% (1.4% of Total Investments)             
750    Sugar Creek, Missouri, Industrial Development Revenue Bonds, Lafarge North America Inc.,    6/13 at 101.00    BBB    654,030 
     Series 2003A, 5.650%, 6/01/37 (Alternative Minimum Tax)             
    Tax Obligation/General – 31.1% (19.8% of Total Investments)             
1,500    Camdenton Reorganized School District R3, Camden County, Missouri, General Obligation Bonds,    No Opt. Call    AAA    1,520,160 
     Series 2005, 5.250%, 3/01/24 – FSA Insured             
500    Jackson County School District R-7, Lees Summit, Missouri, General Obligation Refunding and    3/12 at 100.00    AAA    531,670 
     Improvement Bonds, Series 2002, 5.250%, 3/01/18 – FSA Insured             
500    Missouri School Boards Association, Lease Participation Certificates, Clay County School    3/17 at 100.00    AAA    503,565 
     District 53 Liberty, Series 2007, 5.250%, 3/01/27 – FSA Insured             
1,630    North Kansas City School District, Missouri, General Obligation Bonds, Series 2003A,    3/13 at 100.00    AA+    1,634,287 
     5.000%, 3/01/23             
1,000    Puerto Rico, General Obligation and Public Improvement Bonds, Series 2001A, 5.500%, 7/01/20 –    No Opt. Call    AAA    1,028,370 
     MBIA Insured             
2,020    Ritenour Consolidated School District, St. Louis County, Missouri, General Obligation Bonds,    No Opt. Call    A1    2,269,490 
     Series 1995, 7.375%, 2/01/12 – FGIC Insured             
1,405    St. Louis Board of Education, Missouri, General Obligation Refunding Bonds, Series 2003A,    4/13 at 100.00    AAA    1,436,894 
     5.000%, 4/01/19 – FSA Insured             
270    St. Louis County Pattonville School District R3, Missouri, General Obligation Bonds, Series    3/14 at 100.00    AAA    279,434 
     2004, 5.250%, 3/01/20 – FSA Insured             
8,825    Total Tax Obligation/General            9,203,870 
    Tax Obligation/Limited – 27.8% (17.7% of Total Investments)             
600    Chesterfield, Missouri, Certificates of Participation, Series 2005, 5.000%, 12/01/24 – FGIC Insured    12/15 at 100.00    Aa1    568,134 
80    Cottleville, Missouri, Certificates of Participation, Series 2006, 5.250%, 8/01/31    8/14 at 100.00    N/R    69,342 
490    Fenton, Missouri, Tax Increment Revenue Bonds, Gravois Bluffs Redevelopment Project, Series    4/14 at 100.00    N/R    482,082 
     2006, 4.500%, 4/01/21             
315    Fulton, Missouri, Tax Increment Revenue Bonds, Fulton Commons Redevelopment Project, Series    6/16 at 100.00    N/R    248,592 
     2006, 5.000%, 6/01/28             
475    Kansas City Tax Increment Financing District, Missouri, Tax Increment Revenue Bonds,    6/14 at 102.00    N/R    408,248 
     Briarcliff West Project, Series 2006A, 5.400%, 6/01/24             
415    Missouri Development Finance Board, Independence, Infrastructure Facilities Revenue Bonds,    3/16 at 100.00    A+    385,734 
     Crackerneck Creek Project, Series 2006C, 5.000%, 3/01/28             
360    Missouri Development Finance Board, Infrastructure Facilities Revenue Bonds, Branson Landing    6/15 at 100.00    BBB+    302,861 
     Project, Series 2005A, 5.000%, 6/01/35             
450    Monarch-Chesterfield Levee District, St. Louis County, Missouri, Levee District Improvement    3/10 at 101.00    AAA    471,006 
     Bonds, Series 1999, 5.750%, 3/01/19 – MBIA Insured             
500    Osage Beach, Missouri, Tax Increment Revenue Bonds, Prewitts Point Transportation Development    5/12 at 102.00    N/R    417,040 
     District, Series 2006, 5.000%, 5/01/23             
200    Riverside Industrial Development Authority, Missouri, Industrial Development Revenue Bonds,    5/17 at 100.00    BBB    178,680 
     Riverside Horizon, Series 2007A, 5.000%, 5/01/27 – ACA Insured             
600    Riverside, Missouri, L-385 Levee Redevelopment Plan Tax Increment Revenue Bonds, Series 2004,    5/15 at 100.00    BBB    578,778 
     5.250%, 5/01/20             
1,380    Springfield Center City Development Corporation, Missouri, Lease Revenue Bonds, Jordan Valley    11/11 at 100.00    Aaa    1,379,903 
     Park Parking Garage, Series 2002D, 5.000%, 11/01/22 – AMBAC Insured             
2,000    Springfield Public Building Corporation, Missouri, Lease Revenue Bonds, Jordan Valley Park    6/10 at 100.00    AAA    2,104,120 
     Projects, Series 2000A, 6.125%, 6/01/21 – AMBAC Insured             
    St. Joseph Industrial Development Authority, Missouri, Tax Increment Bonds, Shoppes at North             
    Village Project, Series 2005A:             
340     5.375%, 11/01/24    11/14 at 100.00    N/R    296,837 
400     5.500%, 11/01/27    11/14 at 100.00    N/R    346,928 
8,605    Total Tax Obligation/Limited            8,238,285 
    Transportation – 5.0% (3.2% of Total Investments)             
500    Kansas City, Missouri, Passenger Facility Charge Revenue Bonds, Kansas City International    4/11 at 101.00    AAA    464,150 
     Airport, Series 2001, 5.000%, 4/01/23 – AMBAC Insured (Alternative Minimum Tax)             
1,000    St. Louis Land Clearance Redevelopment Authority, Missouri, Revenue Refunding and Improvement    9/09 at 102.00    N/R    1,005,680 
     Bonds, LCRA Parking Facilities, Series 1999C, 7.000%, 9/01/19             
1,500    Total Transportation            1,469,830 
    U.S. Guaranteed – 24.6% (15.6% of Total Investments) (4)             
685    Fenton, Missouri, Tax Increment Refunding and Improvement Revenue Bonds, Gravois Bluffs    10/12 at 100.00    N/R (4)    760,597 
     Redevelopment Project, Series 2002, 6.125%, 10/01/21 (Pre-refunded 10/01/12)             
2,500    Missouri Health and Educational Facilities Authority, Revenue Bonds, SSM Healthcare System,    6/11 at 101.00    AAA    2,679,023 
     Series 2001A, 5.250%, 6/01/28 (Pre-refunded 6/01/11) – AMBAC Insured             
1,000    Missouri Health and Educational Facilities Authority, Revenue Bonds, St. Anthony’s Medical    12/10 at 101.00    A (4)    1,093,880 
     Center, Series 2000, 6.250%, 12/01/30 (Pre-refunded 12/01/10)             
80    St. Louis County Pattonville School District R3, Missouri, General Obligation Bonds, Series    3/14 at 100.00    AAA    87,063 
     2004, 5.250%, 3/01/20 (Pre-refunded 3/01/14) – FSA Insured             
500    St. Louis County, Missouri, GNMA Collateralized Mortgage Revenue Bonds, Series 1993D, 5.650%,    No Opt. Call    N/R (4)    526,555 
     7/01/20 (Alternative Minimum Tax) (ETM)             
1,000    St. Louis Municipal Finance Corporation, Missouri, Leasehold Revenue Bonds, Carnahan    2/12 at 100.00    A3 (4)    1,088,320 
     Courthouse, Series 2002A, 5.750%, 2/15/16 (Pre-refunded 2/15/12) – FGIC Insured             
950    Texas County, Missouri, Hospital Revenue Bonds, Texas County Memorial Hospital, Series 2000,    6/10 at 100.00    N/R (4)    1,036,384 
     7.250%, 6/15/25 (Pre-refunded 6/15/10)             
6,715    Total U.S. Guaranteed            7,271,822 
    Water and Sewer – 15.4% (9.8% of Total Investments)             
640    Metropolitan St. Louis Sewerage District, Missouri, Revenue Bonds, Wastewater System, Series    5/14 at 100.00    AAA    650,483 
     2004A, 5.000%, 5/01/20 – MBIA Insured             
2,965    Missouri Environmental Improvement and Energy Resources Authority, Water Facility Revenue    12/16 at 100.00    AAA    2,477,080 
     Bonds, Missouri-American Water Company, Series 2006, 4.600%, 12/01/36 – AMBAC Insured             
     (Alternative Minimum Tax) (UB)             
1,000    Missouri Environmental Improvement and Energy Resources Authority, Water Pollution Control and    1/13 at 100.00    Aaa    1,017,060 
     Drinking Water Revenue Bonds, Series 2003B, 5.125%, 1/01/21             
350    Missouri Environmental Improvement and Energy Resources Authority, Water Pollution Control Revenue    No Opt. Call    Aaa    392,781 
     Bonds, State Revolving Fund Program – Kansas City Project, Series 1997C, 6.750%, 1/01/12             
4,955    Total Water and Sewer            4,537,404 
$        47,415    Total Investments (cost $47,850,264) – 157.1%            46,481,077 
    Floating Rate Obligations – (7.5)%            (2,225,000) 
    Other Assets Less Liabilities – 4.5%            1,339,930 
    Preferred Shares, at Liquidation Value – (54.1)% (5)            (16,000,000) 
    Net Assets Applicable to Common Shares – 100%           $   29,596,007 

(1)    All percentages shown in the Portfolio of Investments are based on net assets applicable to Common shares 
    unless otherwise noted. 
(2)    Optional Call Provisions: Dates (month and year) and prices of the earliest optional call or redemption. There 
    may be other call provisions at varying prices at later dates. Certain mortgage-backed securities may be 
    subject to periodic principal paydowns. 
(3)    Ratings: Using the higher of Standard & Poor’s Group (“Standard & Poor’s”) or Moody’s Investor Service, 
    Inc. (“Moody’s”) rating. Ratings below BBB by Standard & Poor’s or Baa by Moody’s are considered to be 
    below investment grade. 
    The Portfolio of Investments reflects the ratings on certain bonds insured by AMBAC, CIFG, FGIC, MBIA 
    and XLCA as of February 29, 2008. Subsequent to February 29, 2008, at least one rating agency reduced 
    the rating for AMBAC-insured bonds to AA and at least one rating agency further reduced the ratings for 
    CIFG-insured, FGIC-insured and XLCA-insured bonds. As of February 29, 2008, one or more rating agencies 
    have placed each of these insurers on “negative credit watch”, which may presage one or more rating 
    reductions for such insurer or insurers in the future. If one or more insurers’ ratings are reduced by these 
    rating agencies, it would likely reduce the effective rating of many of the bonds insured by that insurer 
    or insurers. 
(4)    Backed by an escrow or trust containing sufficient U.S. Government or U.S. Government agency securities 
    which ensure the timely payment of principal and interest. Such investments are normally considered to 
    be equivalent to AAA rated securities. 
(5)    Preferred Shares, at Liquidation Value as a percentage of total investments is (34.4)%. 
N/R    Not rated. 
(ETM)    Escrowed to maturity. 
(UB)    Underlying bond of an inverse floating rate trust reflected as a financing transaction pursuant to the 
    provisions of SFAS No. 140. 

Income Tax Information

The following information is presented on an income tax basis. Differences between amounts for financial statement and federal income tax purposes are primarily due to the treatment of paydown gains and losses, timing differences in recognizing taxable market discount, timing differences in recognizing certain gains and losses on investment transactions and the treatment of investments in inverse floating rate transactions subject to SFAS No. 140. To the extent that differences arise that are permanent in nature, such amounts are reclassified within the capital accounts on the Statement of Assets and Liabilities presented in the annual report, based on their federal tax basis treatment; temporary differences do not require reclassification. Temporary and permanent differences do not impact the net asset value of the Fund. At February 29, 2008, the cost of investments was $45,610,680.

Gross unrealized appreciation and gross unrealized depreciation of investments at February 29, 2008, were as follows:

Gross unrealized:     
  Appreciation    $ 1,137,530  
  Depreciation    (2,491,311) 
Net unrealized appreciation (depreciation) of investments    $(1,353,781) 

Item 2. Controls and Procedures.

  1. The registrant's principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the "1940 Act") (17 CFR 270.30a-3(c))) are effective, as of a date within 90 days of the filing date of this report that includes the disclosure required by this paragraph, based on their evaluation of the controls and procedures required by Rule 30a-3(b) under the 1940 Act (17 CFR 270.30a-3(b)) and Rule 13a-15(b) or 15d-15(b) under the Securities Exchange Act of 1934 (17 CFR 240.13a-15(b) or 240.15d-15(b)).
  2. There were no changes in the registrant's internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a-3(d)) that occurred during the registrant's last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting.

Item 3. Exhibits.

File as exhibits as part of this Form a separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the 1940 Act (17 CFR 270.30a-2(a)), exactly as set forth below: See EX-99 CERT attached hereto.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)         Nuveen Missouri Premium Income Municipal Fund         

By (Signature and Title)          /s/ Kevin J. McCarthy                    
                                                  Kevin J. McCarthy
                                                  Vice President and Secretary

Date         April 29, 2008        

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)         /s/ Gifford R. Zimmerman                    
                                                 Gifford R. Zimmerman
                                                 Chief Administrative Officer (principal executive officer) 

Date         April 29, 2008        

By (Signature and Title)         /s/ Stephen D. Foy                              
                                                 Stephen D. Foy
                                                 Vice President and Controller (principal financial officer) 

Date        April 29, 2008