Form N-Q

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

FORM N-Q


QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number         811-7616         

        Nuveen Missouri Premium Income Municipal Fund         
(Exact name of registrant as specified in charter)

Nuveen Investments
        333 West Wacker Drive, Chicago, Illinois 60606         
(Address of principal executive offices) (Zip code)


Kevin J. McCarthy—Vice President and Secretary
        333 West Wacker Drive, Chicago, Illinois 60606         
(Name and address of agent for service)

Registrant's telephone number, including area code:         312-917-7700        

Date of fiscal year end:            5/31          

Date of reporting period:         8/31/07         

Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (§§ 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.

A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. § 3507.

Item 1. Schedule of Investments

    Portfolio of Investments (Unaudited)             
    Nuveen Missouri Premium Income Municipal Fund (NOM)             
    August 31, 2007             
Principal        Optional Call         
Amount (000)    Description (1)    Provisions (2)    Ratings (3)    Value 
    Consumer Staples – 3.3% (2.2% of Total Investments)             
$          1,000    Missouri Development Finance Board, Solid Waste Disposal Revenue Bonds, Procter and Gamble    No Opt. Call    AA–   $   1,055,390 
     Inc., Series 1999, 5.200%, 3/15/29 (Alternative Minimum Tax)             
    Education and Civic Organizations – 3.6% (2.3% of Total Investments)             
250    Lincoln University, Missouri, Auxillary System Revenue Bonds, Series 2007, 5.125%, 6/01/37 –    6/17 at 100.00    AAA    256,365 
     AGC Insured             
500    Missouri Health and Educational Facilities Authority, Revenue Bonds, St. Louis Priory School,    2/08 at 101.00    A3    505,675 
     Series 2000, 5.650%, 2/01/25             
365    Missouri Health and Educational Facilities Authority, Revenue Bonds, Webster University,    4/11 at 100.00    Aaa    384,528 
     Series 2001, 5.500%, 4/01/18 – MBIA Insured             
1,115    Total Education and Civic Organizations            1,146,568 
    Health Care – 18.8% (12.1% of Total Investments)             
710    Cape Girardeau County Industrial Development Authority, Missouri, Health Facilities Revenue    6/17 at 100.00    N/R    672,001 
     Bonds, Southeast Missouri Hospital Association, Series 2007, 5.000%, 6/01/27             
480    Clinton County Industrial Development Authority, Missouri, Revenue Bonds, Cameron Regional    12/17 at 100.00    N/R    413,040 
     Medical Center, Series 2007, 5.000%, 12/01/37             
750    Joplin Industrial Development Authority, Missouri, Health Facilities Revenue Bonds, Freeman    2/15 at 102.00    BBB+    752,993 
     Health System, Series 2004, 5.500%, 2/15/29             
500    Missouri Health & Educational Facilities Authority, Saint Lukes Episcopal-Presbyterian    6/11 at 101.00    AAA    511,230 
     Hospitals Revenue Bonds, Series 2001, 5.250%, 12/01/26 – FSA Insured             
    Missouri Health and Educational Facilities Authority, Revenue Bonds, BJC Health System,             
    Series 2003:             
1,500     5.125%, 5/15/25    5/13 at 100.00    AA    1,518,375 
1,155     5.250%, 5/15/32    5/13 at 100.00    AA    1,173,965 
425    Missouri Health and Educational Facilities Authority, Revenue Bonds, Lake Regional Health    2/08 at 100.00    BBB+    427,461 
     System, Series 1996, 6.500%, 2/15/21             
500    Missouri Health and Educational Facilities Authority, Revenue Bonds, Lake Regional Health    2/14 at 100.00    BBB+    506,090 
     System, Series 2003, 5.700%, 2/15/34             
6,020    Total Health Care            5,975,155 
    Housing/Multifamily – 6.6% (4.3% of Total Investments)             
425    Missouri Housing Development Commission, Multifamily Housing Revenue Bonds, Series 2001II,    12/11 at 100.00    AA    440,117 
     5.250%, 12/01/16             
500    St. Charles County Industrial Development Authority, Missouri, FHA-Insured Multifamily Housing    4/08 at 102.00    AAA    502,415 
     Revenue Bonds, Ashwood Apartments, Series 1998A, 5.600%, 4/01/30 – FSA Insured (Alternative             
     Minimum Tax)             
545    St. Louis County Industrial Development Authority, Missouri, GNMA Collateralized Multifamily    10/07 at 102.00    AAA    557,301 
     Housing Revenue Refunding Bonds, South Summit Apartments, Series 1997A, 5.950%, 4/20/17             
600    St. Louis County Industrial Development Authority, Missouri, GNMA Collateralized Multifamily    10/07 at 102.00    AAA    613,566 
     Housing Revenue Refunding Bonds, South Summit Apartments, Series 1997B, 6.000%, 10/20/15             
     (Alternative Minimum Tax)             
2,070    Total Housing/Multifamily            2,113,399 
    Housing/Single Family – 8.8% (5.7% of Total Investments)             
35    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    9/07 at 104.00    AAA    35,493 
     Loan Program, Series 1995C, 7.250%, 9/01/26 (Alternative Minimum Tax)             
100    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    3/10 at 100.00    AAA    101,902 
     Loan Program, Series 2000B-1, 6.250%, 3/01/31 (Alternative Minimum Tax)             
745    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    3/16 at 104.50    AAA    794,483 
     Loan Program, Series 2006E-1, 5.600%, 3/01/37 (Alternative Minimum Tax)             
1,000    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    9/16 at 100.00    AAA    942,440 
     Loan Program, Series 2007A-1, 4.700%, 9/01/27 (Alternative Minimum Tax)             
1,000    Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership    3/17 at 100.00    AAA    934,810 
     Loan Program, Series 2007C-1, 4.800%, 9/01/38 (Alternative Minimum Tax)             
2,880    Total Housing/Single Family            2,809,128 
    Long-Term Care – 8.5% (5.5% of Total Investments)             
1,750    Cole County Industrial Development Authority, Missouri, Revenue Bonds, Lutheran Senior    2/14 at 100.00    N/R    1,759,765 
     Services – Heisinger Project, Series 2004, 5.500%, 2/01/35             
475    Lees Summit Industrial Development Authority, Missouri, Revenue Bonds, John Knox Village    8/17 at 100.00    N/R    445,759 
     Obligated Group, Series 2007A, 5.125%, 8/15/32             
500    St. Louis County Industrial Development Authority, Missouri, Revenue Bonds, Friendship Village    9/17 at 100.00    N/R    483,985 
     of West County, Series 2007A, 5.500%, 9/01/28             
2,725    Total Long-Term Care            2,689,509 
    Materials – 2.4% (1.5% of Total Investments)             
750    Sugar Creek, Missouri, Industrial Development Revenue Bonds, Lafarge North America Inc.,    6/13 at 101.00    BBB    751,305 
     Series 2003A, 5.650%, 6/01/37 (Alternative Minimum Tax)             
    Tax Obligation/General – 29.7% (19.2% of Total Investments)             
1,500    Camdenton Reorganized School District R3, Camden County, Missouri, General Obligation Bonds,    No Opt. Call    AAA    1,582,170 
     Series 2005, 5.250%, 3/01/24 – FSA Insured             
500    Jackson County School District R-7, Lees Summit, Missouri, General Obligation Refunding and    3/12 at 100.00    AAA    528,775 
     Improvement Bonds, Series 2002, 5.250%, 3/01/18 – FSA Insured             
500    Missouri School Boards Association, Lease Participation Certificates, Clay County School    3/17 at 100.00    AAA    525,770 
     District 53 Liberty, Series 2007, 5.250%, 3/01/27 (WI/DD, Settling 9/20/07) – FSA Insured             
1,630    North Kansas City School District, Missouri, General Obligation Bonds, Series 2003A,    3/13 at 100.00    AA+    1,672,510 
     5.000%, 3/01/23             
1,000    Puerto Rico, General Obligation and Public Improvement Bonds, Series 2001A, 5.500%, 7/01/20 –    No Opt. Call    AAA    1,118,920 
     MBIA Insured             
2,020    Ritenour Consolidated School District, St. Louis County, Missouri, General Obligation Bonds,    No Opt. Call    AAA    2,259,249 
     Series 1995, 7.375%, 2/01/12 – FGIC Insured             
1,405    St. Louis Board of Education, Missouri, General Obligation Refunding Bonds, Series 2003A,    4/13 at 100.00    AAA    1,463,139 
     5.000%, 4/01/19 – FSA Insured             
270    St. Louis County Pattonville School District R3, Missouri, General Obligation Bonds, Series    3/14 at 100.00    AAA    287,655 
     2004, 5.250%, 3/01/20 – FSA Insured             
8,825    Total Tax Obligation/General            9,438,188 
    Tax Obligation/Limited – 26.2% (16.9% of Total Investments)             
600    Chesterfield, Missouri, Certificates of Participation, Series 2005, 5.000%, 12/01/24 –    12/15 at 100.00    Aaa    616,074 
     FGIC Insured             
80    Cottleville, Missouri, Certificates of Participation, Series 2006, 5.250%, 8/01/31    8/14 at 100.00    N/R    80,019 
490    Fenton, Missouri, Tax Increment Revenue Bonds, Gravois Bluffs Redevelopment Project, Series    4/14 at 100.00    N/R    490,534 
     2006, 4.500%, 4/01/21             
315    Fulton, Missouri, Tax Increment Revenue Bonds, Fulton Commons Redevelopment Project, Series    6/16 at 100.00    N/R    284,262 
     2006, 5.000%, 6/01/28             
475    Kansas City Tax Increment Financing District, Missouri, Tax Increment Revenue Bonds,    6/14 at 102.00    N/R    468,013 
     Briarcliff West Project, Series 2006A, 5.400%, 6/01/24             
415    Missouri Development Finance Board, Independence, Infrastructure Facilities Revenue Bonds,    3/16 at 100.00    A+    409,763 
     Crackerneck Creek Project, Series 2006C, 5.000%, 3/01/28             
360    Missouri Development Finance Board, Infrastructure Facilities Revenue Bonds, Branson Landing    6/15 at 100.00    BBB+    330,437 
     Project, Series 2005A, 5.000%, 6/01/35             
450    Monarch-Chesterfield Levee District, St. Louis County, Missouri, Levee District Improvement    3/10 at 101.00    AAA    474,669 
     Bonds, Series 1999, 5.750%, 3/01/19 – MBIA Insured             
500    Osage Beach, Missouri, Tax Increment Revenue Bonds, Prewitts Point Transportation Development    5/12 at 102.00    N/R    472,680 
     District, Series 2006, 5.000%, 5/01/23             
200    Riverside Industrial Development Authority, Missouri, Industrial Development Revenue Bonds,    5/17 at 100.00    A    189,092 
     Riverside Horizon, Series 2007A, 5.000%, 5/01/27 – ACA Insured             
600    Riverside, Missouri, L-385 Levee Redevelopment Plan Tax Increment Revenue Bonds, Series 2004,    5/15 at 100.00    BBB    602,394 
     5.250%, 5/01/20             
1,380    Springfield Center City Development Corporation, Missouri, Lease Revenue Bonds, Jordan Valley    11/11 at 100.00    Aaa    1,410,443 
     Park Parking Garage, Series 2002D, 5.000%, 11/01/22 – AMBAC Insured             
2,000    Springfield Public Building Corporation, Missouri, Lease Revenue Bonds, Jordan Valley Park    6/10 at 100.00    AAA    2,119,380 
     Projects, Series 2000A, 6.125%, 6/01/21 – AMBAC Insured             
400    St. Joseph Industrial Development Authority, Missouri, Tax Increment Bonds, Shoppes at North    11/14 at 100.00    N/R    392,092 
     Village Project, Series 2005A, 5.500%, 11/01/27             
8,265    Total Tax Obligation/Limited            8,339,852 
    Transportation – 4.8% (3.1% of Total Investments)             
500    Kansas City, Missouri, Passenger Facility Charge Revenue Bonds, Kansas City International    4/11 at 101.00    AAA    504,585 
     Airport, Series 2001, 5.000%, 4/01/23 – AMBAC Insured (Alternative Minimum Tax)             
1,000    St. Louis Land Clearance Redevelopment Authority, Missouri, Revenue Refunding and Improvement    9/09 at 102.00    N/R    1,026,720 
     Bonds, LCRA Parking Facilities, Series 1999C, 7.000%, 9/01/19             
1,500    Total Transportation            1,531,305 
    U.S. Guaranteed – 27.0% (17.4% of Total Investments) (4)             
685    Fenton, Missouri, Tax Increment Refunding and Improvement Revenue Bonds, Gravois Bluffs    10/12 at 100.00    N/R (4)    760,809 
     Redevelopment Project, Series 2002, 6.125%, 10/01/21 (Pre-refunded 10/01/12)             
2,500    Missouri Health and Educational Facilities Authority, Revenue Bonds, SSM Healthcare System,    6/11 at 101.00    AAA    2,655,073 
     Series 2001A, 5.250%, 6/01/28 (Pre-refunded 6/01/11) – AMBAC Insured             
1,000    Missouri Health and Educational Facilities Authority, Revenue Bonds, St. Anthony’s Medical    12/10 at 101.00    A (4)    1,085,420 
     Center, Series 2000, 6.250%, 12/01/30 (Pre-refunded 12/01/10)             
1,135    Puerto Rico Public Finance Corporation, Commonwealth Appropriation Bonds, Series 2002E,    No Opt. Call    AAA    1,351,047 
     6.000%, 8/01/26 – AGC Insured (ETM)             
80    St. Louis County Pattonville School District R3, Missouri, General Obligation Bonds, Series    3/14 at 100.00    AAA    86,554 
     2004, 5.250%, 3/01/20 (Pre-refunded 3/01/14) – FSA Insured             
500    St. Louis County, Missouri, GNMA Collateralized Mortgage Revenue Bonds, Series 1993D, 5.650%,    No Opt. Call    N/R (4)    536,610 
     7/01/20 (Alternative Minimum Tax) (ETM)             
1,000    St. Louis Municipal Finance Corporation, Missouri, Leasehold Revenue Bonds, Carnahan    2/12 at 100.00    Aaa    1,082,840 
     Courthouse, Series 2002A, 5.750%, 2/15/16 (Pre-refunded 2/15/12) – FGIC Insured             
950    Texas County, Missouri, Hospital Revenue Bonds, Texas County Memorial Hospital, Series 2000,    6/10 at 100.00    N/R (4)    1,034,959 
     7.250%, 6/15/25 (Pre-refunded 6/15/10)             
7,850    Total U.S. Guaranteed            8,593,312 
    Water and Sewer – 15.2% (9.8% of Total Investments)             
640    Metropolitan St. Louis Sewerage District, Missouri, Revenue Bonds, Wastewater System, Series    5/14 at 100.00    AAA    665,088 
     2004A, 5.000%, 5/01/20 – MBIA Insured             
2,965    Missouri Environmental Improvement and Energy Resources Authority, Water Facility Revenue    12/16 at 100.00    AAA    2,727,652 
     Bonds, Missouri-American Water Company, Series 2006, 4.600%, 12/01/36 – AMBAC Insured             
     (Alternative Minimum Tax) (UB)             
1,000    Missouri Environmental Improvement and Energy Resources Authority, Water Pollution Control and    1/13 at 100.00    Aaa    1,048,990 
     Drinking Water Revenue Bonds, Series 2003B, 5.125%, 1/01/21             
350    Missouri Environmental Improvement and Energy Resources Authority, Water Pollution Control    No Opt. Call    Aaa    391,836 
     Revenue Bonds, State Revolving Fund Program – Kansas City Project, Series 1997C,             
     6.750%, 1/01/12             
4,955    Total Water and Sewer            4,833,566 
$        47,955    Total Investments (cost $48,716,777) – 154.9%            49,276,677 
    Floating Rate Obligations – (6.2)%            (1,975,000) 
    Other Assets Less Liabilities – 1.6%            506,972 
    Preferred Shares, at Liquidation Value – (50.3)%            (16,000,000) 
    Net Assets Applicable to Common Shares – 100%           $   31,808,649 

(1)    All percentages shown in the Portfolio of Investments are based on net assets applicable to Common 
    shares unless otherwise noted. 
(2)    Optional Call Provisions: Dates (month and year) and prices of the earliest optional call or redemption. 
    There may be other call provisions at varying prices at later dates. Certain mortgage-backed securities 
    may be subject to periodic principal paydowns. 
(3)    Ratings: Using the higher of Standard & Poor’s or Moody’s rating. Ratings below BBB by Standard & 
    Poor’s Group or Baa by Moody’s Investor Service, Inc. are considered to be below investment grade. 
(4)    Backed by an escrow or trust containing sufficient U.S. Government or U.S. Government agency 
    securities which ensure the timely payment of principal and interest. Such investments are normally 
    considered to be equivalent to AAA rated securities. 
N/R    Not rated. 
WI/DD    Purchased on a when-issued or delayed delivery basis. 
(ETM)    Escrowed to maturity. 
(UB)    Underlying bond of an inverse floating rate trust reflected as a financing transaction pursuant to the 
    provisions of SFAS No. 140. 

Income Tax Information

The following information is presented on an income tax basis. Differences between amounts for financial statement and federal income tax purposes are primarily due to the treatment of paydown gains and losses, timing differences in recognizing taxable market discount, timing differences in recognizing certain gains and losses on investment transactions and the treatment of investments in inverse floating rate transactions subject to SFAS No 140.

At August 31, 2007, the cost of investments was $46,726,874.

Gross unrealized appreciation and gross unrealized depreciation of investments at August 31, 2007, were as follows:

Gross unrealized:     
  Appreciation    $1,360,005 
  Depreciation    (785,583) 
Net unrealized appreciation (depreciation) of investments    $   574,422 

Item 2. Controls and Procedures.

  1. The registrant's principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the "1940 Act") (17 CFR 270.30a-3(c))) are effective, as of a date within 90 days of the filing date of this report that includes the disclosure required by this paragraph, based on their evaluation of the controls and procedures required by Rule 30a-3(b) under the 1940 Act (17 CFR 270.30a-3(b)) and Rule 13a-15(b) or 15d-15(b) under the Securities Exchange Act of 1934 (17 CFR 240.13a-15(b) or 240.15d-15(b)).
  2. There were no changes in the registrant's internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a-3(d)) that occurred during the registrant's last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting.

Item 3. Exhibits.

File as exhibits as part of this Form a separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the 1940 Act (17 CFR 270.30a-2(a)), exactly as set forth below: EX-99 CERT Attached hereto.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)         Nuveen Missouri Premium Income Municipal Fund        

By (Signature and Title)*          /s/ Kevin J. McCarthy                    
                                                    Kevin J. McCarthy
                                                    Vice President and Secretary

Date         October 30, 2007        

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)*         /s/ Gifford R. Zimmerman                    
                                                   Gifford R. Zimmerman
                                                   Chief Administrative Officer (principal executive officer) 

Date         October 30, 2007        

By (Signature and Title)*         /s/ Stephen D. Foy                              
                                                   Stephen D. Foy
                                                   Vice President and Controller (principal financial officer) 

Date        October 30, 2007        

* Print the name and title of each signing officer under his or her signature.