Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BAGLEY RICHARD E
   2. Issuer Name and Ticker or Trading Symbol
ZIOPHARM ONCOLOGY INC [ZIOP] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President, COO & Treasurer
(Last)
(First)
(Middle)
ONE FIRST AVE, BUILDING 34, NAVY YARD PLAZA		 3. Date of Earliest Transaction (Month/Day/Year)
12/31/2009
(Street)

BOSTON, MA 02129		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, $.001 par value 12/31/2009   A(10)   50,000 A $ 0 209,125 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) $ 1.7               (1) 07/01/2014 Common Stock 150,668   150,668 D  
Stock Option (right to buy) $ 4.31               (2) 06/08/2015 Common Stock 63,197   63,197 D  
Stock Option (right to buy) $ 4.31               (3) 09/13/2015 Common Stock 27,417   27,417 D  
Stock Option (right to buy) $ 5.01             04/26/2006 04/26/2016 Common Stock 54,873   54,873 D  
Stock Option (right to buy) $ 5.01               (4) 04/26/2016 Common Stock 40,000   40,000 D  
Stock Option (right to buy) $ 6.49               (5) 12/13/2016 Common Stock 20,000   20,000 D  
Stock Option (right to buy) $ 4.85               (6) 06/18/2017 Common Stock 25,000   25,000 D  
Stock Option (right to buy) $ 2.73               (7) 12/12/2017 Common Stock 75,000   75,000 D  
Stock Option (right to buy) $ 2.14               (8) 06/25/2018 Common Stock 60,000   60,000 D  
Stock Option (right to buy) $ 0.7               (9) 05/13/2019 Common Stock 100,000   100,000 D  
Stock Option (right to buy) $ 2.85 12/31/2009   A   50,000     (11) 12/31/2019 Common Stock 50,000 $ 0 50,000 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BAGLEY RICHARD E
ONE FIRST AVE, BUILDING 34
NAVY YARD PLAZA
BOSTON, MA 02129		   X     President, COO & Treasurer  

Signatures

 /s/ Richard E. Bagley   01/05/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) 50,223 shares vest on each of 7/1/05 and 7/1/06; 50,222 shares vest on 7/1/07.
(2) 21,066 shares vest on each of 7/1/05 and 7/1/06; 21,065 shares vest on 7/1/07.
(3) 9,139 shares vest on each of 9/13/05, 7/1/06 and 7/1/07.
(4) 20,000 shares vest immediately; the remainder vest on 12/14/06.
(5) 6,667 shares vest on each of 12/13/07 and 12/13/08; 6,666 shares vest on 12/13/09.
(6) 8,334 shares vest on 6/18/08; 8,333 shares vest on each of 6/18/09 and 6/18/10.
(7) 25,000 shares vest on each of 12/12/08, 12/12/09 and 12/12/10.
(8) 20,000 shares vest on each of 6/25/2009, 6/25/2010 and 6/25/2011.
(9) 25,000 shares vest immediately; 25,000 shares vest on each of 8/13/2009, 11/13/2009 and 2/13/2010.
(10) Grant of restricted stock; restrictions lapse with respect to 16,667 shares on each of 12/31/2011 and 12/31/2012 and as to 16,666 shares on 12/31/2013.
(11) 16,667 shares vest on each of 12/31/2011 and 12/31/2012 and 16,666 shares vest on 12/31/2013.

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