UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

         Date of Report (Date of earliest event reported): JULY 21, 2006

                              ALPHA INNOTECH CORP.
             (Exact name of registrant as specified in its charter)

          DELAWARE                      1-14257                  58-1729436
(State or other jurisdiction          (Commission              (IRS Employer
       of incorporation)              File Number)           Identification No.)

2401 MERCED STREET, SAN LEANDRO, CALIFORNIA                         94577
 (Address of principal executive offices)                        (Zip Code)

       Registrant's telephone number, including area code: (510) 483-9620

                                       N/A
--------------------------------------------------------------------------------
          (Former name or former address, if changed since last report)

         Check the  appropriate  box below if the Form 8-K filing is intended to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (SEE General Instruction A.2. below):

[_]      Written  communications  pursuant to Rule 425 under the  Securities Act
         (17 CFR 230.425)

[_]      Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17
         CFR 240.14a-12)

[_]      Pre-commencement  communications  pursuant to Rule  14d-2(b)  under the
         Exchange Act (17 CFR 240.14d-2(B))

[_]      Pre-commencement  communications  pursuant to Rule 13e-4(c))  under the
         Exchange Act (17 CFR 240.13e-4c))





ITEM 1.01         ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

         On July  21,  2006,  Alpha  Innotech  Corp.  (the  "Company")  issued a
subordinated  Senior  Convertible  Note in the principal amount of $375,000 (the
"Note") and a warrant to purchase  125,000 shares of the Company's  common stock
(the  "Warrant").  The Company will use the proceeds from the private  placement
for general corporate purposes.

         The Note and the Warrant were issued pursuant to a Securities  Purchase
Agreement (the  "Purchase  Agreement")  between the Company and ETP/FBR  Venture
Capital II, LLC (the  "Purchaser").  The Note will bear interest at a rate of 3%
per  year  and is due on  July  20,  2011  (the  "Maturity  Date").  During  the
occurrence of an "Event of Default"  under the Note, the Note will bear interest
at a rate of 10% per year. The Note is  convertible  into shares of common stock
of the Company at an initial  conversion price of $1.60 per share at any time at
the election of the Purchaser; provided, however, that if the Company will issue
any securities ("New  Securities")  within 180 days of the issuance of the Note,
the  Purchaser,  in its sole  discretion,  can  convert  the Note  into such New
Securities  at the same purchase  price and on the same terms and  conditions as
the Company offering such New Securities to third parties.  If the closing price
of the Company's common stock has been at or above $2.50 per shares for at least
30 consecutive business days, then any remaining principal outstanding under the
Note will automatically convert into common stock of the Company. The Warrant is
exercisable from the six month anniversary of the issuance through July 20, 2016
at the price of $1.20 per share.

         The Note is subordinate  in right of payment to the Company's  existing
"Senior Debt", specifically (1) Loan and Security Agreement with BFI dated March
9, 2004;  and (2) the  Secured  Promissory  Note dated April 8, 2005 and related
loan  documents  in favor of  Alexandria  Finance,  LLC.  The Notes will also be
subordinate  in right of payment to a working  capital  line in an amount not to
exceed $5 million  into  which the  Company  may enter in the future  with prior
written consent of the Purchaser.

                  The  securities  sold pursuant to the Purchase  Agreement have
not yet been registered  under the Securities Act of 1933 and may not be offered
or sold  in the  United  States  in the  absence  of an  effective  registration
statement or exemption from registration requirements.  Pursuant to the Purchase
Agreement,  the  Company is  required to file a  registration  statement  before
December 31, 2006 for purposes of registering the resale of the shares of Common
Stock issuable upon conversion of the Note and the Warrant.

         Pursuant to the Purchase Agreement, the Company has agreed to indemnify
the Purchaser, its affiliates and agents, against certain liabilities, including
liabilities  under the Securities  Act of 1933, as amended.  William  Snider,  a
director of the Company,  is a general partner of the Purchaser.  William Snider
is also a general  partner of ETP/FBR  Venture Capital LLC, which currently owns
approximately  15% of common stock of the Company,  as reported in the Company's
Proxy  Statement  filed with the  Securities  and Exchange  Commission on May 1,
2006.


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ITEM 2.03         CREATION OF A DIRECT  FINANCIAL  OBLIGATION  OR AN  OBLIGATION
                  UNDER AN OFF-BALANCE SHEET ARRANGEMENT OF A REGISTRANT.

         The description of the Purchase Agreement, the Note and the Warrant set
forth  in Item  1.01 of this  Current  Report  on Form  8-K is  incorporated  by
reference herein.

ITEM 3.02         UNREGISTERED SALES OF EQUITY SECURITIES.

         On July 21, 2006, the Company completed a private placement offering of
subordinated  Senior  Convertible Note with the principal amount of $375,000 due
in 2011 (the "Note"). The Note is convertible into shares of common stock of the
Company at an initial  conversion  price of $1.60 per share of common stock. The
description  of the  Purchase  Agreement,  the Note and the Warrant set forth in
Item  1.01 of this  Current  Report  on Form 8-K is  incorporated  by  reference
herein.

         The securities were offered  pursuant to exemptions  from  registration
under Section 4(2) of the Securities Act and Rule 506 of Regulation D. There was
a total of one  purchaser,  which was an  "accredited  investor" as such term is
defined in Regulation D. A legend was placed on each certificate indicating that
the  Note and the  Warrant  have not been  registered  and are  restricted  from
resale.


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                                    SIGNATURE

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                            ALPHA INNOTECH CORP.

Date:    July 26, 2006                      By:      /S/ RON BISSINGER
                                               ---------------------------------
                                               Ron Bissinger
                                               Chief Financial Officer and
                                               Chief Operating Officer


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