AS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION ON APRIL 6, 2006                      REGISTRATION NO.  333-_________
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                                   ----------

                              ALPHA INNOTECH CORP.
             (Exact Name of Registrant as Specified in Its Charter)

            DELAWARE                                             58-1729436
 (State or other jurisdiction of                              (I.R.S. Employer
 incorporation or organization)                              Identification No.)

                               2401 MERCED STREET
                          SAN LEANDRO, CALIFORNIA 94577
                    (Address of principal executive offices)
                                 HASEEB CHAUDHRY
                             CHIEF EXECUTIVE OFFICER
                              ALPHA INNOTECH CORP.
                               2401 MERCED STREET
                          SAN LEANDRO, CALIFORNIA 94577
                                 (510) 483-9620
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                                   ----------

                                   COPIES TO:

                               STEPHEN C. FERRUOLO
                                HELLER EHRMAN LLP
                     4350 LA JOLLA VILLAGE DRIVE, 7TH FLOOR
                            SAN DIEGO, CA 92122-1246
                            TELEPHONE: (858) 450-8400
                            FACSIMILE: (858) 450-8499

                   AMENDED AND RESTATED 1999 STOCK OPTION PLAN
                        2001 MILESTONE STOCK OPTION PLAN
                      NON-QUALIFIED STOCK OPTION AGREEMENT

                         CALCULATION OF REGISTRATION FEE
================================================================================
                                     PROPOSED        PROPOSED
                                      MAXIMUM        MAXIMUM
   TITLE OF                          OFFERING       AGGREGATE         AMOUNT OF
 SECURITIES TO    AMOUNT TO BE        PRICE          OFFERING       REGISTRATION
 BE REGISTERED    REGISTERED(1)     PER SHARE(2)     PRICE(2)           FEE
--------------------------------------------------------------------------------
Common Stock,       854,311            $1.70       $1,452,329         $156.00
$0.01 par value
================================================================================
(1)  Includes  (a)  434,305  shares of  Registrant's  Common  Stock to be issued
     pursuant to the Amended and Restated  1999 Stock  Option Plan,  (b) 120,006
     shares  of  Registrant's  Common  Stock to be issued  pursuant  to the 2001
     Milestone Plan, and (c) 300,000 shares of  Registrant's  Common Stock to be
     issued pursuant to the Non-Qualified Stock Option Agreement.

(2)  Estimated   solely  for  the  purpose  of  computing   the  amount  of  the
     registration  fee pursuant to Rule 457(c) under the Securities Act of 1933,
     as  amended,  based  on the  average  of the  high  and low  prices  of the
     Registrant's  Common Stock  reported on the OTC Bulletin  Board on April 3,
     2006.
================================================================================





                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         The following documents, which have been filed by Alpha Innotech Corp.,
formerly  Xtrana,  Inc.  (the  "Registrant")  with the  Securities  and Exchange
Commission  (the  "Commission"),  are hereby  incorporated  by reference in this
Registration Statement:

         (a)      Registrant's Annual Report on Form 10-KSB, as amended, for the
                  period ended December 31, 2005;

         (b)      The description of the Registrant's  common stock contained in
                  the Registrant's Registration Statement on Form 8-A, filed May
                  1, 1989 under the Securities  Exchange Act of 1934, as amended
                  (the "Exchange Act") including any amendments or reports filed
                  for the purposes of updating such description.

         All documents  subsequently  filed by the Company  pursuant to Sections
13(a),  13(c),  14 or 15(d)  of the  Exchange  Act,  prior  to the  filing  of a
post-effective amendment to this Registration Statement which indicates that all
securities  offered  hereby have been sold or which  deregisters  all securities
remaining  unsold,  shall be  deemed to be  incorporated  by  reference  in this
Registration  Statement  and to be a part hereof from the date of filing of such
documents.

ITEM 4.  DESCRIPTION OF  SECURITIES

         Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         Not applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Section  102  of  the  Delaware   General   Corporation  Law  allows  a
corporation to eliminate the personal liability of directors of a corporation to
the corporation or to any of its  stockholders  for monetary damage for a breach
of his or her  fiduciary  duty as a  director,  except  in the  case  where  the
director  breached  his or her duty of  loyalty,  failed  to act in good  faith,
engaged in intentional  misconduct or knowingly  violated a law,  authorized the
payment of a dividend or approved a stock  repurchase  in  violation of Delaware
corporate  law or  obtained  an  improper  personal  benefit.  The  Registrant's
Certificate of  Incorporation  contains a provision that  eliminates  directors'
personal liability as set forth above.

         Section 145 of the Delaware General  Corporation Law ("DGCL")  provides
that the  Registrant may indemnify an officer or director who is made a party or
threatened to be made a party to any action or proceeding  (including a law suit
or derivative  action) because of his position,  against  expenses  actually and
reasonably  incurred by him in connection  with the action,  if he acted in good
faith in a manner he  reasonably  believed  to be in or not  opposed to the best
interests  of the  Registrant,  and,  with  respect  to any  criminal  action or
proceeding, had no reasonable cause to believe that his conduct was unlawful. If
the officer or director is adjudged liable to the  Registrant,  indemnity can be
made only by court order. If the director or officer is successful on the merits
or  otherwise,  he  must  be  indemnified  against  all  expenses  actually  and
reasonably incurred.  Also, Section 145 of the DGCL provides that the Registrant
may advance expenses incurred by a director or officer in defending an action or
proceeding  if the  director  or officer  agrees to repay such  amounts if it is
determined that he is not entitled to be indemnified.

         Article VII, Section 8.1 of the  Registrant's  Bylaws provides that the
Registrant  shall (a)  indemnify  any officer or director who is made a party or
threatened  to be made a party to any action or


                                       2



proceeding by or in the right of the Registrant, because of his or her position,
against expenses actually and reasonably  incurred by him in connection with the
action or  proceeding,  and (b)  indemnify any officer or director who is made a
party or threatened  to be made a party to any action or proceeding  (other than
an action by or in the right of the Registrant), because of his or her position,
against  expenses,  judgments,  fines and  settlements  actually and  reasonably
incurred  by him in  connection  with the action or  proceeding,  to the fullest
extent permissible under subsections (a) through (e) of Section 145 of the DGCL.
Thus,  directors  and  officers of the  Registrant  will be  indemnified  by the
Registrant  provided  that each such person  acted in good faith and in a manner
that he  reasonably  believed  was in or not  opposed to the  Registrant's  best
interests,  and,  with  respect to any  criminal  action,  if such person had no
reasonable  cause to believe that his conduct was unlawful.  The  Registrant may
not indemnify a director or officer,  absent of court order,  if such person was
found liable to the Registrant and the Registrant must indemnify any director or
officer  who is  successful  on the  merits of his  defense.  Additionally,  the
Registrant  may advance  expenses to a director  or officer in  accordance  with
Section 145 of the DGCL summarized in the preceding paragraph.

         The  Registrant  has  also  obtained  on  behalf  of its  officers  and
directors  insurance  against losses arising from any claim asserted  against or
incurred by such individual in any such capacity, subject to certain exclusions.

         See also the undertakings set out in response to Item 9.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Not applicable.

ITEM 8.  EXHIBITS

Item
No.      Description of Item
----     -----------------------------------------------------------------------
10.1     Amended and Restated 1999 Stock Option Plan  (Incorporated by reference
         to the Registrant's Current Report Form 8-K filed on October 7, 2005)

10.2     2001  Milestone  Stock  Option Plan  (Incorporated  by reference to the
         Registrant's Current Report Form 8-K filed on October 7, 2005)

10.3     Non-Qualified Stock Option Agreement  (Incorporated by reference to the
         Registrant's Current Report Form 8-K filed on December 27, 2005)

10.4     Form of Stock Option Agreement

5.1      Opinion of Heller Ehrman LLP

23.1     Consent of Independent Auditors

23.2     Consent of Heller Ehrman LLP (filed as part of Exhibit 5.1)

24.1     Power of Attorney (See page 5)

ITEM 9.  UNDERTAKINGS

         A.       The undersigned registrant hereby undertakes:

                  (1)      To file,  during any period in which  offers or sales
are being made, a post-


                                       3



effective amendment to this registration statement;

                           (i)      To  include  any   prospectus   required  by
Section 10(a)(3) of the Securities Act of 1933;

                           (ii)     To  reflect in the  prospectus  any facts or
events  arising after the effective date of the  registration  statement (or the
most recent  post-effective  amendment  thereof)  which,  individually or in the
aggregate,  represent a fundamental  change in the  information set forth in the
registration statement; and

                           (iii)    To include  any  material  information  with
respect to the plan of distribution not previously disclosed in the registration
statement  or any  material  change  to  such  information  in the  registration
statement;  provided, however, that paragraphs A(1)(i) and A(1)(ii) do not apply
if the  information  required to be included in a  post-effective  amendment  by
those  paragraphs  is  contained  in periodic  reports  filed by the  registrant
pursuant to Section 13 or 15(d) of the Securities  Exchange Act of 1934 that are
incorporated by reference in the registration statement.

                  (2)      That,  for the purpose of  determining  any liability
under the Securities Act of 1933,  each such  post-effective  amendment shall be
deemed to be a new  registration  statement  relating to the securities  offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

                  (3)      To   remove   from   registration   by   means  of  a
post-effective  amendment any of the securities  being  registered  which remain
unsold at the termination of the offering.

         B.       The  undersigned   registrant   hereby  undertakes  that,  for
purposes of determining  liability under the Securities Act of 1933, each filing
of the  registrant's  annual  report  pursuant to Section  13(a) or 15(d) of the
Securities  Exchange  Act of  1934  that is  incorporated  by  reference  in the
registration  statement shall be deemed a new registration statement relating to
the securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.

         C.       Insofar as indemnification  for liabilities  arising under the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant to the  foregoing  provisions,  or  otherwise,  the
registrant  has been advised that in the opinion of the  Securities and Exchange
Commission  such  indemnification  is against  public policy as expressed in the
Securities Act and is, therefore,  unenforceable.  In the event that a claim for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against  public policy as expressed in the  Securities
Act and will be governed by the final adjudication of such issue.


                                       4



                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the city of San Leandro, State of California, on this 6th day of
April, 2006.

                                             ALPHA INNOTECH CORP.

                                             By: /S/ HASEEB CHAUDHRY
                                                --------------------------------
                                                Haseeb Chaudhry
                                                Chief Executive Officer

                       POWER OF ATTORNEY TO SIGN AMENDMENT

         KNOW  ALL MEN BY THESE  PRESENTS,  that  each  person  whose  signature
appears below does hereby  constitute  and appoint  Haseeb  Chaudhry,  with full
power of  substitution,  such  person's  true and lawful  attorneys-in-fact  and
agents for such person in such person's  name,  place and stead,  in any and all
capacities, to sign any or all amendments (including post-effective  amendments)
to this  Registration  Statement  on Form  S-8 and to file  the  same,  with all
exhibits  thereto,  and  other  documents  in  connection  therewith,  with  the
Securities and Exchange  Commission,  granting unto said  attorneys-in-fact  and
agents full power and  authority  to do and perform each and every act and thing
requisite  and  necessary  to be done in and  about  the  premises  in  order to
effectuate the same as fully, to all intents and purposes,  as he or such person
might or could do in  person,  hereby  ratifying  and  confirming  all that said
attorneys-in-fact  and  agents  may  lawfully  do or cause to be done by  virtue
hereof.

         Pursuant to the  requirements of the Securities Act, this  Registration
Statement on Form S-8 has been signed by the following persons in the capacities
and on the dates indicated.

        Signature                       Capacity                  Date
---------------------------     ------------------------     --------------
                                Chief Executive Officer
/S/ Haseeb Chaudhry             and Director                 April 6, 2006
---------------------------
Haseeb Chaudhry

                                Acting Chief Financial
/s/ Ron Bissinger               Officer and Chief            April 6, 2006
---------------------------     Operating Officer
Ron Bissinger                   (Principal Financial and
                                Accounting Officer)

/s/ William Snider              Chairman                     April 6, 2006
---------------------------
William Snider

/s/ Michael D. Bick, Ph.D       Director                     April 4, 2006
---------------------------
Michael D. Bick, Ph.D.

/s/ James H. Chamberlain        Director                     April 4, 2006
---------------------------
James H. Chamberlain

/s/ John Hodgman                Director                     April 4, 2006
---------------------------
John Hodgman

/s/ Nagesh Mhatre               Director                     April 4, 2006
---------------------------
Nagesh Mhatre

/s/ Darryl Ray, Ph.D.           Director                     April 4, 2006
---------------------------
Darryl Ray, Ph.D.


                                       5



INDEX TO EXHIBITS


Item
No.      Description of Item
----     -----------------------------------------------------------------------

10.1     Amended and Restated 1999 Stock Option Plan  (Incorporated by reference
         to theRegistrant's Current Report Form 8-K filed on October 7, 2005)

10.2     2001  Milestone  Plan  (Incorporated  by reference to the  Registrant's
         Current Report Form 8-K filed on October 7, 2005)

10.3     Non-Qualified Stock Option Agreement  (Incorporated by reference to the
         Registrant's Current Report Form 8-K filed on December 27, 2005)

10.4     Form of Stock Option Agreement

5.1      Opinion of Heller Ehrman LLP

23.1     Consent of Independent Auditors

23.2     Consent of Heller Ehrman LLP (filed as part of Exhibit 5.1)

24.1     Power of Attorney (See page 5)


                                       6