UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       Date of Report (Date of earliest event reported): DECEMBER 20, 2005

                              ALPHA INNOTECH CORP.
             (Exact name of registrant as specified in its charter)

          DELAWARE                   1-14257                     58-1729436
(State or other jurisdiction       (Commission                 (IRS Employer
      of incorporation)            File Number)              Identification No.)


          2401 MERCED STREET, SAN LEANDRO, CALIFORNIA             94577
           (Address of principal executive offices)             (Zip Code)

       Registrant's telephone number, including area code: (510) 483-9620

                                       N/A
--------------------------------------------------------------------------------
          (Former name or former address, if changed since last report)

         Check the  appropriate  box below if the Form 8-K filing is intended to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (SEE General Instruction A.2. below):

         |_|      Written   communications   pursuant  to  Rule  425  under  the
                  Securities Act (17 CFR 230.425)

         |_|      Soliciting material pursuant to Rule 14a-12 under the Exchange
                  Act (17 CFR 240.14a-12)

         |_|      Pre-commencement  communications  pursuant  to  Rule  14d-2(b)
                  under the Exchange Act (17 CFR 240.14d-2(b))

         |_|      Pre-commencement  communications  pursuant  to Rule  13e-4(c))
                  under the Exchange Act (17 CFR 240.13e-4c))





ITEM 1.01         ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

         On December 20, 2005,  the Board of Directors of Alpha  Innotech  Corp.
("Alpha Innotech" or the "Company") approved a new compensation  program for the
Chairman of the Board of Directors of the  Company,  Bill Snider.  Under the new
compensation  program, Mr. Snider shall be entitled to receive cash compensation
for his service as Chairman of the Board of  Directors  equal to  $8,333.33  per
month for the period  beginning  January 1, 2006 and ending June 30, 2006,  with
potential  additional  cash payment upon the  Company's  achievement  of certain
performance  milestones.  Additionally,  Mr.  Snider  was  granted  an option to
purchase  300,000  shares of Common  Stock,  such option to vest with respect to
200,000  shares on June 30,  2006 and with  respect  to  additional  100,000  on
December 31, 2006, subject to the Company's  achievement of certain  performance
milestones. A copy of the option agreement is filed as Exhibit 10.1 to this Form
8-K.

ITEM 4.01         CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT.

         (a) On December 22, 2005, we ended the  engagement of Hein & Associates
LLP as our  independent  registered  public  accounting  firm.  The decision was
approved by our Audit Committee and our Board of Directors.

         The  report of Hein &  Associates  LLP on the  Xtrana,  Inc.  financial
statements  for the  fiscal  year ended  December  31,  2004 did not  contain an
adverse opinion or disclaimer of opinion.  However,  the report was modified due
to an  uncertainty  about the  ability of Xtrana,  Inc.  to  continue as a going
concern.  During the fiscal  year ended  December  31,  2004 and the  subsequent
interim period preceding the termination,  there were no disagreements with Hein
& Associates LLP on any matter of accounting principles or practices,  financial
statement disclosure,  or auditing scope or procedure,  which disagreements,  if
not resolved to the satisfaction of Hein & Associates LLP would have caused Hein
& Associates LLP to make reference to the subject matter of the disagreements in
connection  with its  report  on the  financial  statements  for  such  years or
subsequent interim periods.

         We  requested  that  Hein &  Associates  LLP  furnish  us with a letter
addressed to the Securities and Exchange  Commission  stating  whether or not it
agrees  with the our  statements  in this  Item  4.01(a).  A copy of the  letter
furnished by Hein & Associates  LLP in response to that request,  dated December
27, 2005, is filed as Exhibit 16.1 to this Form 8-K.

         (b) On December  22,  2005,  Rowbotham & Company LLP was engaged as our
new independent  registered  public  accounting firm. During the two most recent
fiscal years and the interim  period  preceding  the  engagement  of Rowbotham &
Company  LLP, we have not  consulted  with  Rowbotham  & Company  LLP  regarding
either: (i) the application of accounting principles to a specified transaction,
either  completed  or  proposed,  or the type of  audit  opinion  that  might be
rendered  on our  financial  statements;  or (ii) any matter that was either the
subject of a disagreement  or event  identified in paragraph  (a)(1)(iv) of Item
304 of Regulation S-B.

ITEM 9.01         FINANCIAL STATEMENTS AND EXHIBITS.

         (d)      EXHIBITS.

                  See the Exhibit Index  following  the  signature  page of this
                  Current  Report on Form 8-K for a list of the  exhibits  filed
                  herewith.


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                                    SIGNATURE

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                     ALPHA INNOTECH CORP.



Date:    December 27, 2005           By:      /S/ HASEEB CHAUDHRY               
                                        ----------------------------------------
                                              Haseeb Chaudhry
                                              Chief Executive Officer


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                                  EXHIBIT INDEX

EXHIBIT
NUMBER            DESCRIPTION
-------           -----------

10.1              Option Agreement with Mr. Snider

16.1              Letter  furnished by Hein & Associates  LLP dated December 27,
                  2005


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